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All Journal PAMERI : Pattimura Medical Review
Samuel Maruanaya
Fakultas Kedokteran Universitas Pattimura
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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PENGARUH PEMBERIAN EKSTRAK ETANOL ALGA COKELAT (Sargassum sp.) TERHADAP HITUNG JENIS LEUKOSIT MENCIT (Mus musculus) PASCA DIINDUKSI STRES AKUT Reski Toding Allo Lebang; Vina Z. Latuconsina; Halidah Rahawarin; Ingrid Hutagalung; Parningotan Y. Silalahi; Samuel Maruanaya
PAMERI Vol 3 No 2 (2021)
Publisher : Fakultas Kedokteran Universitas Pattimura

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2838.538 KB) | DOI: 10.30598/pamerivol3issue2page8-24

Abstract

Glucocorticoids are stress hormones that suppress normal immune responses by blocking Th1 cells. Glucocorticoids have an impact on decreasing the body's immune system and changes in leukocyte differentiation. Sargassum sp. is one type of brown algae that lives in the sea. Sargassum sp. contains metabolite compounds that are immunomodulatory. This study aims to determine the number of types of leukocytes in mice that are induced by stress and given ethanol extract of Sargassum sp. Pure experimental research design with post test only control group design. Thirty mice were divided into five treatment groups, namely the normal control group (KN), negative control (K-), positive control (K +), ethanol extract of Sargassum sp. 35% (P1) and 70% (P2). At K-, K +, P1 and P2 were given stress treatment with the FST (Forced Swim Test) method to see immobility time in mice. The treatment was given for seven days and on the 8th day the intracardial mice were taken. Observation of leukocytes from the blood smear of mice was carried out using a microscope with 1000x magnification. Observation data were analyzed by ANOVA. The results showed that the P1 group could reduce the percentage of neutrophils and monocytes but increase the percentage of lymphocytes, while the P2 group showed a decrease in the percentage of neutrophils, an increase in the percentage of lymphocytes, but could not decrease the percentage of monocytes compared to P1. The mean percentage of eosinophils and basophils did not change significantly, both in the treatment group and in the control group. However, statistical data shows no significant change between groups. So it can be concluded that stress treatment given to mice does not have a significant effect on the average percentage of monocytes, lymphocytes, neutrophils, eosinophils and basophils after being induced by stress.
KARAKTERISTIK DAN TINGKAT KEPATUHAN MINUM OBAT ANTI HIPERTENSI PADA PASIEN HIPERTENSI DI PUSKESMAS AIR BESAR Daniel Sinaga; Irwan Irwan; Samuel Maruanaya; Presli G Siahaya
PAMERI Vol 4 No 2 (2022)
Publisher : Fakultas Kedokteran Universitas Pattimura

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (239.032 KB) | DOI: 10.30598/pamerivol4issue1page15-29

Abstract

Hypertension known widely as a cardiovascular disease in which patients has a blood pressure above normal. Treatments on hypertension can be fully completed when a few factors are met. One of the factors mentioned is hypertension drug adherence. This study is conducted to know characteristics on hypertension drugs adherence patients in Puskesmas Air Besar. This study is an observational research is a descriptive cross-sectional study. The sample in this study is hypertension patients in Puskesmas Air Besar Desa Batu Merah in 2021, 108 patients, will be given a questionnaire to fill. The data then taken and analyzed using univariate approach. This study shows that in Puskesmas Air Besar Desa Batu Merah most patients are in the range of 45-54 of age which are 31 patients (28,78%), most patients as many as 80 patients (74,07%) are female, most patients as many as 52 patients (48,15%) are on low level of education category, most patients as many as 46 patients (42,60%) are housewife, most patients as many as 25 patients (23,15%) does not have any family history for hypertension, most patients as many as 101 patients (93,52%) does not smoke, most patients as many as 67 patients (62,04%) found in this study are mostly obese, and most patients found in this study as many as 68 patients (62,96%) has low category on adherence level.
Co-Authors Daniel Sinaga Halidah Rahawarin Ingrid Hutagalung Irwan Irwan Parningotan Y. Silalahi Reski Toding Allo Lebang Vina Z. Latuconsina