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All Journal KOVALEN: Jurnal Riset Kimia Jurnal Penelitian Sains
Boima Situmeang
Jurusan Kimia, Sekolah Tinggi Analis Kimia Cilegon
Chemical Engineering, Chemistry & Bioengineering Chemistry Mathematics Physics

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Sintesis dan Karakterisasi Cangkang Kapsul Non Gelatin dari Rumput Laut (Eucheumma cottonii) dan Kaktus Koboi (Cereus peruvianus) untuk Sistem Penghantaran Obat: Synthesis and Characterization of Non Gelatinized Capsule Shells from Seaweed (Eucheumma cottonii) and Koboi Cactus (Cereus peruvianus) for Drug Delivery Systems Micha Mahardika; Ninik Triayu Susparini; Dany Dewaldo; Boima Situmeang; Fauzan Amin
KOVALEN: Jurnal Riset Kimia Vol. 9 No. 1 (2023): April Edition
Publisher : Chemistry Department, Mathematics and Natural Science Faculty, Tadulako University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/kovalen.2023.v9.i1.16098

Abstract

Research on drug delivery systems continues to develop, including making the latest formulations on capsule shells as a medium for drug delivery. The effort that has been done was developing non-gelatine drug delivery materials made from the combination of seaweed and cactus. The main component in making gel on seaweed and cactus is the polysaccharide pectin. This study aims to make and determine the characterization of capsule shells from a combination of seaweed and cactus. Capsule shells are made from a combination of pectin extracts from seaweed and cactus with 5 different ratios of 0:4 (A), 1:3 (B), 2:2 (C), 3:1 (D), and 4:0 (E). The characterization involved weight uniformity test, disintegration time test, water swelling test, and dissolution test. Pectin from green seaweed and koboi cactus weighed 235 g and 75 g. The capsule shell weights based on Farmakope Indonesia sixth edition were 307.2, 311.6, 309.7, 304.6, and 308.7 mg. The capsule shell disintegration times, based on Farmakope Indonesia sixth edition, 2020, were 15,16, 14, 21, and 12 minutes, and the best result of the water swelling test was C capsule (2:2) of 666.7%. The results of the capsule shell dissolution test showed that the reduction of the capsule shells did not exceed 10% for 30 minutes according to the Farmakope Indonesia sixth edition. The capsule shells made from a combination of seaweed and cactus can be used as material in drug delivery systems. Non-gelatinized capsule shell which is expected to have anti-inflammatory activity.
Perbandingan Aktivitas Antioksidan Ekstrak Etil asetat dan Metanol Daun Tumbuhan Matoa (Pometia pinnata) Boima Situmeang; Weny JA Musa; Agus Mulyadi; Agus Malik Ibrahim; Holisha Widiyanto; Nurhayati Bialangi
Jurnal Penelitian Sains Vol 26, No 1 (2024)
Publisher : Faculty of Mathtmatics and Natural Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56064/jps.v26i1.919

Abstract

Matoa (Pometia pinnata) is a plant from the Sapindaceae family that is widely distributed throughout the Asia-Pacific region, including Indonesia, Malaysia, Thailand, and Sri Lanka. In Indonesia, the Matoa plant is commonly found in Java, Sumatra, and Papua. Empirically, the leaves of the Matoa plant have been utilized by the community as a traditional remedy for treating hypertension, fever, and diarrhea. The aim of this study was to test the antioxidant activity of ethyl acetate extract and methanol extract of Matoa leaves. Extraction was performed using the maceration method. The antioxidant activity was evaluated using UV-Visible spectroscopy. The free radical used was DPPH at a concentration of 50 ppm. The absorbance was measured at a wavelength of 517 nm. The antioxidant activity of the ethyl acetate extract of Matoa leaves was 38.87 ppm and 37.73 ppm. The antioxidant activity of the methanol extract of Matoa leaves was 27.99 ppm and 33.25 ppm. Based on the antioxidant activity values, both the ethyl acetate and methanol extracts of Matoa leaves have the potential as a source of natural antioxidants. 
Co-Authors Agus Malik Ibrahim Agus Mulyadi Dany Dewaldo Fauzan Amin Holisha Widiyanto Micha Mahardika Ninik Triayu Susparini Nurhayati Bialangi Weny JA Musa