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All Journal EKSAKTA: Journal of Sciences and Data Analysis KOVALEN: Jurnal Riset Kimia Jurnal Pendidikan Kimia (JPKim) Jurnal Kartika Kimia Jurnal Ilmiah Teknik Kimia

Micha Mahardika

Jurusan Kimia, Sekolah Tinggi Analis Kimia Cilegon

Author-ID : 6029311

Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Earth & Planetary Sciences Education Environmental Science Materials Science & Nanotechnology

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Articles

SINTESIS DAN KARAKTERISASI NANOPARTIKEL EMAS MENGGUNAKAN BIOREDUKTOR DARI EKSTRAK DAUN BERENUK Fauzan Amin; Micha Mahardika; Siti Fatimah
Jurnal Ilmiah Teknik Kimia Vol 4, No 2 (2020): JURNAL ILMIAH TEKNIK KIMIA
Publisher : Program Studi Teknik Kimia, Universitas Pamulang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32493/jitk.v4i2.5101

Perkembangan teknologi industri di segala sektor semakin menuntut lahirnya perangkat-perangkat yang lebih sederhana, berukuran kecil, dengan bahan murah, tetapi memiliki kemampuan yang sama atau lebih canggih daripada perangkat-perangkat sebelumnya. Tuntutan ini dapat dijawab dengan adanya nanoteknologi. Nanopartikel emas (AuNPs) merupakan bagian dari nanoteknologi yang semakin luas manfaatnya dalam kehidupan manusia antara lain di bidang lingkungan, biomedis, tekstil, industri elektronika serta energi . Sintesis Au-NPs diawali dengan mereduksi ion Au(III) mengunakan reduktor dari tumbuhan karena lebih aman dan ramah lingkungan dibandingkan dengan bahan anorganik lainnya. Salah satu tumbuhan yang potensial digunakan sebagai bioreduktor adalah daun berenuk (Crescentia cujete Linn) yang melimpah keberadaanya tapi belum banyak dimanfaatkan oleh manusia. Penelitian ini bertujuan menentukan pengaruh volume bioreduktor terhadap pembentukan AuNPs secara statistik dan ukuran AuNPs menggunakan TEM. Hasil penelitian menunjukkan bahwa pada volume bioreduktor tidak berpengaruh terhadap pembentukan AuNPs setelah diolah menggunakan SPSS, mempunyai ukuran rata-rata 11,249 nm dengan bentuk morfologi anisotropik.

EFFECT OF COOKING ON IRON AVAILIBILITY IN FORTIFIED HOMEMADE TEMPEH Micha Mahardika; Fauzan Amin; Arda Ganda Risdiyono
EKSAKTA: Journal of Sciences and Data Analysis VOLUME 1, ISSUE 1, February 2020
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/EKSAKTA.vol1.iss1.art4

Iron deficiency anemia is a type of anemia caused by iron deficiency, decreasing in the number of healthy red blood cells. The purpose of this study was to make fortified Fe-EDTA and find out the changes in iron availability after cooking (frying and boiling). The biological availability test for iron was carried out in vitro by simulating human digestion using enzyme pepsin and pancreatin-bile solution. The iron variants added were 0, 0.033, 0.066, 0.099, 0.132, and 0.166 % of EDTA iron on 30 grams of raw soybeans to be homemade tempeh. Test results with Atomic Absorption Spectrometry (AAS) showed that the highest Fe content of 12.54 mg was obtained by adding 0.166% of EDTA iron to raw tempeh. But after cooking, there is a decrease in fried and boiled tempeh. The results obtained from the addition of 0.166% of iron-EDTA are 7.74 mg for fried tempeh, and 8.40 mg for boiled tempeh. The results of the addition of Fe-EDTA 0.166% for raw tempeh and boiled match to the value of daily Fe intake to reduce iron anemia in the amount of 8-15 mg / day according to Recommendation Dietary Allowance (RDA). The addition of 0.166% of Fe-EDTA fortification on dried tempeh, it still has not match to the recommended level.Received: 13 September 2019; Accepted: 30 December 2019; Published: 12 January 2020

Synthesis and characterization of capsule shells non gelatin grass jelly leaves-seaweed as drug delivery system material Micha Mahardika; Fauzan Amin; Ika Agustia Umami; Boima Situmeang; Agus Malik Ibrahim
Jurnal Pendidikan Kimia (JPKim) Vol 13, No 1 (2021): April
Publisher : Pascasarjana Universitas Negeri Medan

Drug delivery system is a system that describes the journey of a drug to its target location. The main component of the drug delivery system is gelatin. The leaves of grass jelly-seaweed are needed as a raw material for gelatin. The main component of gelling agents in grass jelly leaves and seaweed is a low-methoxy pectin polysaccharide. Pectin from previous study is used as a synthesis material for hard capsule shells with the addition of other ingredients, which are Na-CMC, sorbitol, and water. The characterization results of capsule shells with variations in the composition of grass jelly-seaweed leaves 0: 4, 1: 3, 2: 2, 3: 1, and 4: 0 (A, B, C, D and E) have a disolving time of 12 minutes 45 seconds; 15 minutes 53 seconds; 23 minutes 10 seconds; 15 minutes 35 seconds and 18 minutes 12 seconds. The swelling degree test each of 200%; 266,7%; 303.3%; 586.7% and 643.3%. Furthermore, the shells of grass jelly-seaweed leaf capsules were tested for their material performance in the cefadroxyl disolving test with variations in sampling time of 10, 20, and 30 minutes.Keywords: Cefadroxyl, Drug delivery system, Green grass jelly leaves, Non-gelatin capsules, Seaweed

Synthesis and characterization of gold nanoparticles using fruit extract of Crescentia cujete L Fauzan Amin; Micha Mahardika; Nada Morisca
Jurnal Pendidikan Kimia (JPKim) Vol 11, No 3 (2019): December
Publisher : Pascasarjana Universitas Negeri Medan

Nanoparticles play important role in biotechnology such as food and drug industries. Gold nanoporticles(Au-NPS) have been wdely used in any drug therapies like drug delivery system for cancer, tumor, and diabetes treatment. Recently, Au-NPS have been devoleped to increase drug selectivity between tumor and normal cells. In the present studies, we use the fresh fruit ekstract (FFE) of crescentia cujete L mediated blue green alga for the synthesis of Au-NPS. The characterization of Au-NPS was carried out by using UV-Vis spectroscopy, Fourier transform infrared spectroscopy (FTIR), and Transmission Electron spectroscopy (TEM). UV-VIS spectrometry indicated formation of nanoparticles which produces an intense absorbance peak at 531 nm. FTIR reveales the functional group involved in reduction and stabilization of Au-NPS. TEM have shown the morphology of Au-NPS with mean size 10,11 nm.Keywords: Crescentia cujete; gold nanoparticles; green alga

Iron Fortification and bioavailibility of homemade tempeh with sesame seed Fauzan Amin; Micha Mahardika; Dianastya Yuniarti
Jurnal Pendidikan Kimia (JPKim) Vol 12, No 3 (2020): December
Publisher : Pascasarjana Universitas Negeri Medan

Iron deficiency anemia is caused by the low intake of iron from foods. The purpose of this research was to make fortified tempeh using sesame seed with a high potential utility as iron fortificant. The iron bioavailability was carried out in vitro by simulating human digestion for raw and cooked tempeh. The iron fortificant added were 0, 10, 20, 25, 30 ,40 and 50% of sesame seed to substitute 100 grams of soybeans. The results of this study showed that the highest Fe content of 0.4539 mg was obtained by replacing 50% soybean with sesame seed. But after cooking, there is a decrease in boiled for 10, 20, 30,40,50% variants and increase in fried for 0, 10, 25, 30% variants.Keywords: Anemia, Tempeh, Fortification, Sesame seed

Fortifikasi dan Ketersediaan Zat Besi pada Pangan Berbasis Kedelai Menggunakan Fortifikan Biji Wijen Fauzan Amin; Micha Mahardika; Boima Situmeang; Agus Malik Ibrahim; Uvi Dwiyana; Umar Fauzi
Jurnal Kartika Kimia Vol 4 No 2 (2021): Jurnal Kartika Kimia
Publisher : Department of Chemistry, Faculty of Sciences and Informatics, University of Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/jkk.v4i2.91

Anemia merupakan salah satu masalah gizi paling umum di negara berkembang, termasuk Indonesia. Kekurangan zat besi dapat menimbulkan gangguan atau hambatan pertumbuhan pada sel tubuh maupun sel otak. Fortifikasi makanan merupakan salah satu upaya yang dapat dilakukan di antara berbagai solusi perbaikan gizi. Salah satu alternatif bahan pangan yang dapat difortifikasi adalah bahan pangan berbasis kedelai seperti tahu dan susu kedelai. Biji wijen merupakan biji-bijian yang belum banyak diolah menjadi fortifikan. Penentuan ketersediaan Fe secara in vitro pada tahu dan susu kedelai terfortifikasi biji wijen ditentukan dengan kelarutan Fe pada kondisi fsiologikalnya menggunakan enzim pepsin pankreatin dan ekstrak bile. Kadar Fe tertinggi pada tahu mentah, olahan rebus, dan goreng terfortifikasi terjadi pada penambahan fortifikan sebesar 20, 40, dan 50% dengan ketersediaan Fe 0,2456; 1,9206; dan 0,3384 mg. Susu kedelai terfortifikasi mengandung kadar Fe tertinggi terdapat pada sampel E (60 g kedelai dan 40 g biji wijen) sebesar 0,4967 mg. Kata kunci: anemia, biji wijen, fortifikasi

Sintesis dan Karakterisasi Cangkang Kapsul Non Gelatin dari Rumput Laut (Eucheumma cottonii) dan Kaktus Koboi (Cereus peruvianus) untuk Sistem Penghantaran Obat: Synthesis and Characterization of Non Gelatinized Capsule Shells from Seaweed (Eucheumma cottonii) and Koboi Cactus (Cereus peruvianus) for Drug Delivery Systems Micha Mahardika; Ninik Triayu Susparini; Dany Dewaldo; Boima Situmeang; Fauzan Amin
KOVALEN: Jurnal Riset Kimia Vol. 9 No. 1 (2023): April Edition
Publisher : Chemistry Department, Mathematics and Natural Science Faculty, Tadulako University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/kovalen.2023.v9.i1.16098

Research on drug delivery systems continues to develop, including making the latest formulations on capsule shells as a medium for drug delivery. The effort that has been done was developing non-gelatine drug delivery materials made from the combination of seaweed and cactus. The main component in making gel on seaweed and cactus is the polysaccharide pectin. This study aims to make and determine the characterization of capsule shells from a combination of seaweed and cactus. Capsule shells are made from a combination of pectin extracts from seaweed and cactus with 5 different ratios of 0:4 (A), 1:3 (B), 2:2 (C), 3:1 (D), and 4:0 (E). The characterization involved weight uniformity test, disintegration time test, water swelling test, and dissolution test. Pectin from green seaweed and koboi cactus weighed 235 g and 75 g. The capsule shell weights based on Farmakope Indonesia sixth edition were 307.2, 311.6, 309.7, 304.6, and 308.7 mg. The capsule shell disintegration times, based on Farmakope Indonesia sixth edition, 2020, were 15,16, 14, 21, and 12 minutes, and the best result of the water swelling test was C capsule (2:2) of 666.7%. The results of the capsule shell dissolution test showed that the reduction of the capsule shells did not exceed 10% for 30 minutes according to the Farmakope Indonesia sixth edition. The capsule shells made from a combination of seaweed and cactus can be used as material in drug delivery systems. Non-gelatinized capsule shell which is expected to have anti-inflammatory activity.

Determination of Boron Concentration at Sausage Samples with Distillation of Ester Borane Method using Fluorescence Spectrophotometry Isna Lailatusholihah -; Aisyiah Restutiningsih Putri Utami; Micha Mahardika
KOVALEN: Jurnal Riset Kimia Vol. 9 No. 3 (2023): December Edition
Publisher : Chemistry Department, Mathematics and Natural Science Faculty, Tadulako University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/kovalen.2023.v9.i3.16673

The study of borax contamination in food samples was successfully analyzed. This study used sausage samples using the Fluorescence Spectrophotometry method. Sausage samples were from Daerah Istimewa Yogyakarta (DIY). This study used 4 sausage samples. The samples were given labels A, B, C, and D. The steps of the research were optimation of distillation time, optimation of catalyst, optimation of solvent, and then followed by analyzing the borax concentration on sausage samples. Based on this study, the optimum distillation time was 24 hours. On the other hand, the best catalysts and solvents were sulphuric acid and ethanol. The A and B samples contained borax contamination and the concentration was under 5 ppm. The C and D samples contained borax contamination and the concentration was above 5 ppm. The conclusions were that A and B samples were not given borax addition and C and D samples were given borax addition.

Co-Authors Agus Malik Ibrahim Aisyiah Restutiningsih Putri Utami Arda Ganda Risdiyono Boima Ramses Situmeang Boima Situmeang Boima Situmeang Dany Dewaldo Dianastya Yuniarti Fauzan Amin Fauzan Amin Fauzan Amin Fauzan Amin Fauzan Amin Fauzan Amin Ibrahim, Agus Malik Ika Agustia Umami Isna Lailatusholihah - Nada Morisca Ninik Triayu Susparini Siti Fatimah Umar Fauzi Uvi Dwiyana

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