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All Journal Prosiding Seminar Informasi Kesehatan Nasional Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan
Tiara Ajeng L
Universitas Duta Bangsa Surakarta
Humanities Biochemistry, Genetics & Molecular Biology Chemistry Education Health Professions Medicine & Pharmacology Nursing Public Health

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GAMBARAN PENGGUNAAN ANTIDIABETES ORAL PADA PASIEN DIABETES MELLITUS TIPE 2 : LITERATURE REVIEW Kusumaningtyas Siwi Artini; Tiara Ajeng L; Cindy Septia Saifana
Prosiding Seminar Informasi Kesehatan Nasional 2022 : SIKesNas 2022
Publisher : Fakultas Ilmu Kesehatan Universitas Duta Bangsa Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (261.481 KB) | DOI: 10.47701/sikenas.vi.2079

Abstract

Latar belakang: Diabetes mellitus merupakan suatu penyakit kronis karena gangguan metabolikyang ditandai dengan peningkatan kadar gula darah atau hiperglikemi. Menurut dataInternational Diabetes Federation, pada tahun 2021 indonesia menduduki urutan ke 5 dari 10negara dengan jumlah penderita diabetes tertinggi dengan jumlah 19,5 juta orang yang apabilatidak diatasi dengan baik dikhawatirkan prevalensi semakin meningkat. Tujuan: literature reviewini bertujuan untuk membahas rasionalitas penggunaan antidiabetes oral pada pasien diabetesmellitus tipe 2 di Indonesia. Metode Penelitian: penelitian ini menggunakan metode literaturereview. Artikel yang digunakan dalam penelitian ini berasal dari google Scholar, Pubmed, Scientdirect. Hasil: obat antidiabetes oral yang paling banyak digunakan adalah metformin kemudianglimepiride yang digunakan secara tunggal, diikuti dengan kombinasi metformin dan glikazid.Kesimpulan: pada pengobatan diabetes mellitus tipe 2 obat antidiabetes tunggal paling banyakdigunakan adalah metformin. Hal ini telah sesuai dengan panduan pengobatan diabetes mellitustipe 2.
Formulasi Dan Uji Aktivitas Antibakteri Sediaan Krim Ekstrak Etanol Kulit Buah Manggis (Garcinia Mangostana Linn.) Terhadap Bakteri Propionibacterium Acnes ATCC 1335 Lydia Fitriana; Tiara Ajeng L; Anita Dwi Septiarini S; Danang Raharjo
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 2 No. 1 (2024): Januari : OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v2i2.197

Abstract

The skin is the widest organ that makes up the human body which is the outermost and covers the entire surface of the body. The outermost location causes the skin to receive stimulation for the first time such as touch stimulation, pain, or bad influences from outside. This causes the skin to stretch due to disease. One of the most common skin diseases suffered by people is acne. Acne occurs generally triggered by the bacterium Propionibacterium acnes (gram positive bacteria). Effective acne treatment can use antibiotics, but inappropriate use of antibiotics can lead to resistance. Therefore it is necessary to have alternative therapies from plants that have the potential as antibacterial. One of the natural ingredients from plants that have antibacterial properties is mangosteen (Garcinia mangostana Linn.)This research was conducted using a descriptive experimental method with the aim of knowing the presence of antibacterial activity in cream preparations of ethanol extract of mangosteen rind (Garcinia mangostana Linn.) against Propionibacterium acnes bacteria as seen from the inhibition of bacteria with varying concentrations of 10%, 15% and 25% by using paper disc diffusion method and solid liquid dilution method. The positive control used clindamycin cream and the negative control used 1% DMSO. Analysis of the diameter of the inhibition data was carried out using the One Way ANOVA test. The preparation formulation that has the largest diameter in the diffusion test is F3 with a concentration of 25% with an average inhibition of 6.36 in the medium category. The MIC and KBM values in the dilution method were at a concentration of 12.5%. The results of a normally distributed One Way ANOVA are measured with a value (P> 0.05). Mangosteen peel extract (Garcinia mangostana Linn.) has antibacterial activity against Propionibacterium acnes bacteria.
Co-Authors Anita Dwi Septiarini S Cindy Septia Saifana Kusumaningtyas Siwi Artini Lydia Fitriana