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All Journal Medfarm: Jurnal Farmasi dan Kesehatan Journal of Fundamental and Applied Pharmaceutical Science Jurnal Rumpun Ilmu Kesehatan JURNAL JAMU KUSUMA Proceeding of International Conference Health, Science And Technology (ICOHETECH) Prosiding Seminar Informasi Kesehatan Nasional Jurnal Medika Nusantara Parapemikir Jurnal Ilmiah Farmasi

Kusumaningtyas Siwi Artini

Universitas Duta Bangsa Surakarta

Author-ID : 4113652

Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Education Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Medicine & Pharmacology Nursing Physics Public Health

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Total Flavonoid Content of Lemongrass Leaf (Cymbogoncitratus (DC.) Stapf) Extract and Antioxidant Activity with Frap Ahda Maulida Ulufan Nurinnafi'a; Kusumaningtyas Siwi Artini; Desy Ayu Irma Permatasari
Journal of Fundamental and Applied Pharmaceutical Science Vol 3, No 1 (2022): August
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v3i1.15556

Lemongrass (Cymbogoncitratus (DC.) Stapf) leaves contain alkaloids, saponins, tannins, anthraquinones, steroids, phenols and flavonoids. Flavonoids act as antioxidants as they can reduce free radicals. This study aims to determine the total flavonoid content, antioxidant activity, and IC50 value of lemongrass leaf extract (Cymbogoncitratus (DC.) Stapf). Extracts were made by maceration using 96% ethanol as solvent. Testing of total flavonoid content with the AlCl3 method using UV-Vis spectrophotometry was carried out three times. The antioxidant activity test used the FRAP (ferric reducing antioxidant power) method on extracts containing 100, 200, 300, 400, and 500 ppm. The test results showed that the leaf extract of citronella (Cymbogoncitratus (DC.) Stapf) had a total flavonoid content of 22,60 mg QE/g extract. Furthermore, there was antioxidant activity in the leaf extract of lemongrass (Cymbogoncitratus (DC.) Stapf indicated by the formation of a blue color purplish when reacted with FRAP solution, and IC50 extract value was 71,59 ppm and included in the category of strong antioxidants.

Literature Review: Antioxidant Test of Basil Leaves (Ocimum Sanctum) Noka Riyani; Kusumaningtyas Siwi Artini; Tatiana Siska Wardani
Proceeding of International Conference on Science, Health, And Technology 2021: Proceeding of the 2nd International Conference Health, Science And Technology (ICOHETECH)
Publisher : LPPM Universitas Duta Bangsa Surakarta

Basil leaves is family of lamiaceace, which is known as daun kemangi (Indonesia). This plant is widely use as a herb. Indonesian also used basil leaves as a seasoning in their food. It has chemical compound such as flavonoid so it has an antioxidant effect. The aim of this reseach is to find out the antioxidant effect of the basil leaves, the chemical compound of basil leaves. The method by reviewing online articles at Pubmed, sciencedirect and Google Scholar. Cemichal compound wes identified in some reseach. It show different potential base on the extraction proses. The antioxidant effect was tested using the DPPH method for determination of IC50. By reviewing articles, we can conclude that basil leaves have an antioxidant effect.

Literature Review: Hand sanitizer formulation from extract and essential oil of betel leaf (Piper betle Linn.) As well as antibacterial activity test Weri veranita; Kusumaningtyas Siwi Artini; Danang Raharjo; Ferry Effendi
Proceeding of International Conference on Science, Health, And Technology 2021: Proceeding of the 2nd International Conference Health, Science And Technology (ICOHETECH)
Publisher : LPPM Universitas Duta Bangsa Surakarta

The pandemic encourages us to look for various ways to overcome it, from various sides, including physical mobility management, vaccine development, to drug discovery. Indonesia has long recognized and used medicinal plants as an effort to overcome health efforts. Piper betle Linn or betel is a plant known to have antiseptic properties. Traditional use is usually by boiling the betel leaf. Utilization of stew and betel leaf extract as natural antibacterial agents has advantages. This is because these plants have natural compounds that are safer than the use of drugs that contain synthetic ingredients. Research reveals that betel leaf with an extract content of more than 15% is equivalent to alcohol and ethanol content. Research and utilization of betel leaf as an antiseptic and hand sanitizer products have been done a lot, one of which is by using extracts and essential oils from betel leaves. The aim of this study was to compare the antibacterial activity of the betel leaf hand sanitizer formulation using extracts and essential oils against the tested bacteria. This research is a literature review. Information on the hand sanitizer formulation of Piper betle Linn betel leaf was collected from online databases such as Pub Med, Direct Scient, and Google Scholar.

Literature Review: The Potencial Effect of Dandang Gendis Leave (Clinacanthus nutans Lindau) Kusumaningtyas Siwi Artini; Weri Veranita; Tatiana Siska Wardani
Proceeding of International Conference on Science, Health, And Technology 2021: Proceeding of the 2nd International Conference Health, Science And Technology (ICOHETECH)
Publisher : LPPM Universitas Duta Bangsa Surakarta

Indonesian are used to use herb to medicate a disease. One of the medicinal plants used is Clinacnathus nutans (Burm.f.) Lindau. Clinacnathus nutans Lindau is a traditional plant, commonly known as dandang gendhis (Java – Indonesia), ki tajam (Sunda – Indonesia), belalai gajah (Malaysia), Sabah Snake Grass (Singapore), and phaya yo (Thailand). It belonging to the Acanthaceae family. This study aimed to find out the the effect of giving the extract of Clinacnathus nutans Lindau to subject. This research method was using literature review. The information about Clinacanthus nutans Lindau collected from an online database such as Pub Med, Scient direct and Google Scholar. The number of chemical compound were identified from leaves. It contain of alkaloid, flavonoid, polifenol, saponin and tanin Some of the potential effect shown such as antihypoglycemic, antioxidant and anticancer, and analgetic. In this study,we can conclude that in the future Clinacnathus nutans Lindau is valuable to use as herbal medicine with more investigation.

Literature Study of Three Plant Formulations with Anti-Candida Albicans Activity in Feminine Liquid Soap Preparations Tatiana Siska Wardani; Kusumaningtyas Siwi Artini; Ilham Latansa
Proceeding of International Conference on Science, Health, And Technology 2021: Proceeding of the 2nd International Conference Health, Science And Technology (ICOHETECH)
Publisher : LPPM Universitas Duta Bangsa Surakarta

Candida albicans is a fungus that causes vaginal discharge in women. Leucorrhoea is a discharge from the vagina with a relatively small frequency, odorless, and clear. In Indonesia, there are many plants that have medicinal properties that are used in traditional medicine and are believed to have antifungal activities.Feminine hygiene soap is a liquid cleansing preparation for femininity which is made from basic ingredients and is used to clean the feminine area without causing irritation to the skin.This study aims to provide information about plants that have anti-fungal activity and their formulation as a good female liquid soap preparation with their activity as an anti-candida albicans. The method in this research is by searching literature studies from various journals. The results showed that each female liquid soap preparation with plants as the active substance gave different inhibition diameters. The difference between the active substance and the additive in the formulation affects the resulting inhibition diameter. Based on the results of a literature review, basil,cabbage (Brassica oleracea var. capitata alba) and waru (Hibiscus tiliaceus), has activity as an antifungal against Candida albicans.

ANTIOXIDANT ACTIVITY OF ETHANOL EXTRACTS AND FRACTIONS KETEPENG CINA LEAVES(Cassia alata) WITH ABTS Assay Danang Raharjo; Nur Hidayah; Kusumaningtyas Siwi Artini
Proceeding of International Conference on Science, Health, And Technology Proceeding of the 3rd International Conference Health, Science And Technology (ICOHETECH)
Publisher : LPPM Universitas Duta Bangsa Surakarta

Antioxidants are compounds that have a molecular structure that can donate electrons to free radical molecules and can break the chain reaction of free radicals. This research was conducted to analyze the flavonoid content in the ethanol extract of ketepeng cina leaves and to determine the antioxidant activity of the ethanol extract and the fraction of the ketepeng cina leaves. This research is an experimental descriptive study. Ketepeng cina leaves were extracted using 96% ethanol, then partitioned using the liquid-liquid partition method. Flavonoid levels were determined using UV-VIS spectrophotometry at a wavelength of 435 nm. Antioxidant activity test using the ABTS method at a wavelength of 740 nm. The results showed that the flavonoid content of the ethanol extract of the ketepeng cina leaves was 11,054 ± 0.228 QE. The results of the antioxidant activity test of the ethanol extract, n-hexane fraction, ethyl acetate fraction, and water fraction with IC50 values were 23,709 ppm, 106,598 ppm, 14,534 ppm, and 49,844 ppm, respectively. The highest antioxidant activity was indicated by the ethyl acetate fraction with an IC50 value of 14,534 ppm with very strong activity

EFEK PENGHAMBATAN ENZIM XANTIN OXIDASE OLEH EKSTRAK ETANOL BIJI PEPAYA (Carica papaya Linn.) SECARA IN VITRO Kusumaningtyas Siwi Artini; Danang Raharjo; Eny Wijayanti
Prosiding Seminar Informasi Kesehatan Nasional 2021: SIKesNas 2021
Publisher : Fakultas Ilmu Kesehatan Universitas Duta Bangsa Surakarta

Penyakit metabolik seperti asam urat ditandai dengan tingginya kadar asam urat dikarenakan gangguan metabolisme purin. Peningkatan kadar asam urat didalam darah disebabkan karena adanya defisiensi enzim Hypoxanthine-Guanine Phosphoribosyl Transferase (HGPRT) yang mana enzim ini berfungsi untuk mengubah purin menjadi nukleotida purin sehingga dapat digunakan kembali sebagai penyusun DNA dan RNA sehingga kekurangan enzim ini bisa mengakibatkan kadar asam urat meningkat. Dalam biji buah pepaya (Carica papaya Linn.) terdapat kandungan zat fitokimia seperti flavonoid, saponin, dan tanin yang berkhasiat menormalkan kadar lipid dan kadar asam urat. Penelitian ini merupakan penelitian experimental yang bertujuan untuk mengehatui potensi ekstrak biji pepaya (Carica papaya Linn.) dalam menghambat enzim xantine oxidase. Uji penghambatan enzim xantine oksidase dilakukan dengan menggunakan metode spektrofotometri UV – VIS. Penelitian ini menggunakan uji terhadap enzim xantine oxidase yang diberi allopurinol sebagai kontrol positif dengan konsentrasi 0,625ppm; 1,25ppm; 2,5ppm; 5ppm; dan 10ppm, dan enzim xantine oxidase yang diberi ekstrak biji pepaya dengan konsentrasi 5ppm; 50ppm;100ppm; 200ppm; dan 300ppm. Pada uji enzim xantine oksidase yang direaksikan dengan allopurinol diketahui bahwa daya hambat terbesar pada konsentrasi 10ppm yaitu sebesar 69,815% dan nilai IC50 0,28 sedangkan pada uji enzim xantine oxidase yang direaksikan dengan ekstrak biji pepaya diketahui daya hambat terbesar pada konsentrasi 300ppm yaitu 86,105% dan nilai IC50 101,80. Dari penelitian ini dapat disimpulkan bahwa ekstrak biji pepaya dapat menghambat enzim xantine oksidase secara bermakna.Kata Kunci : asam urat, ekstrak biji pepaya (Carica papaya Linn.), enzim xantine oxidase

GAMBARAN PENGGUNAAN ANTIDIABETES ORAL PADA PASIEN DIABETES MELLITUS TIPE 2 : LITERATURE REVIEW Kusumaningtyas Siwi Artini; Tiara Ajeng L; Cindy Septia Saifana
Prosiding Seminar Informasi Kesehatan Nasional 2022 : SIKesNas 2022
Publisher : Fakultas Ilmu Kesehatan Universitas Duta Bangsa Surakarta

Latar belakang: Diabetes mellitus merupakan suatu penyakit kronis karena gangguan metabolikyang ditandai dengan peningkatan kadar gula darah atau hiperglikemi. Menurut dataInternational Diabetes Federation, pada tahun 2021 indonesia menduduki urutan ke 5 dari 10negara dengan jumlah penderita diabetes tertinggi dengan jumlah 19,5 juta orang yang apabilatidak diatasi dengan baik dikhawatirkan prevalensi semakin meningkat. Tujuan: literature reviewini bertujuan untuk membahas rasionalitas penggunaan antidiabetes oral pada pasien diabetesmellitus tipe 2 di Indonesia. Metode Penelitian: penelitian ini menggunakan metode literaturereview. Artikel yang digunakan dalam penelitian ini berasal dari google Scholar, Pubmed, Scientdirect. Hasil: obat antidiabetes oral yang paling banyak digunakan adalah metformin kemudianglimepiride yang digunakan secara tunggal, diikuti dengan kombinasi metformin dan glikazid.Kesimpulan: pada pengobatan diabetes mellitus tipe 2 obat antidiabetes tunggal paling banyakdigunakan adalah metformin. Hal ini telah sesuai dengan panduan pengobatan diabetes mellitustipe 2.

UJI AKTIFITAS TABIR SURYA DENGAN METODE SUN PROTEKTION FACTOR PADA SEDIAAN LOTION KOMBINASI EKSTRAK KAYU MANIS dan TEMULAWAK Istiara Subekti; Tatiana Siska Wardani; Kusumaningtyas Siwi Artini
Prosiding Seminar Informasi Kesehatan Nasional 2022 : SIKesNas 2022
Publisher : Fakultas Ilmu Kesehatan Universitas Duta Bangsa Surakarta

Ekstrak kayu manis (Cinnamomum burmanni (Nees & T.Nees) dan ekstrak temulawak(Curcuma zanthorrhiza Roxb.) memiliki aktivitas sun protektion factor (SPF) secara spektroskopi.Penelitian ini bertujuan untuk mengetahui potensi tabir surya dengan pengukuran (SPF) sertamengetahui kategori tabir surya pada sediaan lotion kombinasi ekstrak kayu manis EKM danekstrak temulawak (ETM). Metode penelitian ini menggunakan metode observasi eksperimentaldengan 3 variasi kombinasi V1 EKM 0.25% ETM 0,75% V2 EKM 0,5% ETM 0,5% V3 EKM0,75% ETM 0,25%. Observasi meliputi uji fisik, uji nilai SPF, serta uji stabilitas dengan metodecycling test. Aktivitas tabir surya lotion di tentukan secara spektrofotometri dengan serikonsentrasi 1250ppm, 2500ppm, 3750ppm dan 5000ppm untuk menentukan nilai (SPF). Hasilpenelitian menunjukan V1 memiliki nilai SPF 5,03±15,60 V2 5,47±16,92 dan V3 6,92±18,39.Lotion dengan kombinasi ekstrak kayu manis dan ekstrak temulawak memiliki kategori tingkatkemampuan ultra dibuktikan dengan nilai SPF ≥15. Variasi konsentrasi terbaik adalah V3dibuktikan dengan nilai SPF paling tinggi.

RASIONALITAS PENGGUNAAN OBAT ANTIDIABETES PADA PASIEN DM TIPE 2 PASIEN RAWAT JALAN DI RSUD Dr. MOEWARDI SURAKARTA Kusumaningtyas Siwi Artini; Tiara Ajeng Listyani; Galuh Puspitasari
MEDFARM: Jurnal Farmasi dan Kesehatan Vol 12 No 1 (2023): MEDFARM: Jurnal Farmasi dan Kesehatan
Publisher : LPPM Akafarma Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48191/medfarm.v12i1.160

Diabetes mellitus adalah penyakit degeneratif yang terjadi karena adanya gangguan produksi insulin sehingga terjadi peningkatan kadar insulin. Prevalensi kejadian Diabetes mellitus terus meningkat karena gaya hidup yang kurang baik. Pasien dengan penyakit diabetes mellitus harus menjalani pengobatan seumur hidup dan membutuhkan obat yang tepat dan rasional agar tujuan terapi tercapai. Tujuan dari penelitian ini adalah untuk mengetahui profil penggunaan antidiabetes dan rasionalitas penggunaan obat antidiabetes melitus pada pasien diabetes melitus tipe 2 yang menjalani rawat jalan di RSUD Dr. Moewardi Surakarta. Penelitian ini dilaksanakan dengan menggunakan metode cross sectional dan pengambilan data dilaksanakan dengan cara retrospektif. Hasil dari penelitian ini adalah obat antidiabetes diberikan secara kombinasi dengan antiabetes oral atapun dengan insulin. Rasionalitas tepat penggunaan obat didapatkan hasil tepat diagnosis sebesar 100%, tepat indikasi 100%, tepat obat 100%, tepat dosis 100%, dan tepat interval waktu pemberian 100%. Kata kunci: antidiabetes, diabetes mellitus tipe 2, rasional, rsud dr. moewardi ABSTRACT Diabetes mellitus is a degenerative disease that occurs due to impaired insulin production resulting in increased insulin levels. The prevalence of diabetes mellitus continues to increase due to unfavorable lifestyles. Patients with diabetes mellitus must undergo lifelong treatment and need appropriate and rational drugs so that therapeutic goals are achieved. The purpose of this study was to determine the profile of antidiabetic use and the rationality of antidiabetic drug use in type 2 diabetes mellitus patients undergoing outpatient care at RSUD Dr. Moewardi Surakarta. This research was conducted using the method cross sectional and data collection was carried out retrospectively. The results of this study are anti-diabetic drugs given in combination with oral anti-diabetics or with insulin. Rationality for the right drug use results in the right diagnosis of 100%, the right indication 100%, the right drug 100%, the right dose 100%, and the right time interval for giving 100%. Keywords: antidiabetic, diabetes mellitus type 2, rational, rsud dr. moewardi

Co-Authors Ahda Maulida Ulufan Nurinnafi'a Amanda Anisawati Angga Aulia Sahadatun Annisa Kusuma Wardhani Annissha Azzahra Wurnasari Bangkit Riska Permata Cindy Septia Saifana Desy Ayu Irma Permatasari Diana Putri Arfianingsih Eny Wijayanti Ferry Effendi Galuh Puspita Sari Galuh Puspitasari Ilham Latansa Isna Nur K Istiara Subekti Kharisma Jayak Pratama Noka Riyani Nur Hidayah Rifda Husna Arifah Tatiana Siska Wardani Tiara Ajeng L Tiara Ajeng Listyani Veranita, Weri

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