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All Journal SURABAYA PHYSICAL MEDICINE AND REHABILITATION JOURNAL Borneo Journal of Pharmacy
Hening Laswati
Universitas Airlangga
Chemical Engineering, Chemistry & Bioengineering Health Professions Medicine & Pharmacology

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Fitness Level in Mojo VI Surabaya Elementary School Students Nabilah Ishanan Ramadhan; Hening Laswati; Kristanti Wanito Wigati; Sri Mardjiati Mei Wulan
Surabaya Physical Medicine and Rehabilitation Journal Vol. 5 No. 1 (2023): SPMRJ, FEBRUARY 2023
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/spmrj.v5i1.23767

Abstract

Background: A sedentary lifestyle such as watching TV and video for a long time, or playing PlayStation, is experienced by two-thirds of children, especially in developing countries. The fitness levels of elementary school students are not all in a good condition. So far, there is no study of healthy children with 2-minute walk test method. Therefore, the researcher is interested to do research about fitness level with 2-minute walk test. Aim: The purpose of this research is to determine the fitness level of Mojo VI elementary school Surabaya. Material and Methods: The method used in this research is descriptive observational with a cross-sectional research design using total sampling. Data collection was using primary data obtained from the results of 2-minute walk test. Results: The fitness level based on age obtained the highest average value at the oldest age of 12 years old with an average of 207.30 m±17.359. While the lowest average value at the youngest age was 184.96 m±15.991. Meanwhile, based on gender, it obtained higher average value in male students (201.81 m±22.06 m) than female students (194.30 m±14.29 m). Conclusion: The higher the age, the higher the student's fitness level. Meanwhile, based on gender, the fitness level of a male is higher than a woman.
Metabolite Profiling of the Environmental-Controlled Growth of Marsilea crenata Presl. and Its In Vitro and In Silico Antineuroinflammatory Properties Burhan Ma'arif; Faisal Akhmal Muslikh; Dilla Amalia; Anisah Mahardiani; Luthfi Achmad Muchlasi; Pramudita Riwanti; Maximus Markus Taek; Hening Laswati; Mangestuti Agil
Borneo Journal of Pharmacy Vol. 5 No. 3 (2022): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v5i3.3262

Abstract

This study was aimed to evaluate the metabolite contents and antineuroinflammatory potential of Marsilea crenata Presl. grown under a controlled environmental condition. The antineuroinflammatory test has been carried out in vitro using ethanolic extract of M. crenata leaves on HMC3 microglia cells. An in silico approach was applied to predict the active compounds of the extract. The HMC3 microglia cells were induced with IFNγ to create prolonged inflammatory conditions and then treated with 96% ethanolic extract of the M. crenata leaves of 62.5, 125, and 250 μg/mL. The expression of MHC II was analyzed using the ICC method with the CLSM instrument. Metabolites of the extract were profiled using UPLC-QToF-MS/MS instrument and MassLynx 4.1 software. In silico evaluation was conducted with molecular docking on 3OLS protein using PyRx 0.8 software, and physicochemical properties of the compounds were analyzed using SwissADME webtool. The ethanolic extract of M. crenata leaves could reduce the MHC II expression in HMC3 microglia cells in all concentrations with the values 97.458, 139.574, and 82.128 AU. The result of metabolite profiling found 79 compounds in the extract. In silico evaluation showed that 19 compounds gave agonist interaction toward 3OLS, and three met all parameters of physicochemical analysis. The ethanolic extract of the environmental-controlled growth of M. crenata leaves antineuroinflammatory activity on HMC3 microglia cells. The extract was predicted to contain some phytoestrogen compounds which act as 3OLS agonists.
Co-Authors Anisah Mahardiani Burhan Ma'arif Dilla Amalia Faisal Akhmal Muslikh Luthfi Achmad Muchlasi Mangestuti Agil Maximus M Taek Nabilah Ishanan Ramadhan Pramudita Riwanti Sri Mardjiati Mei Wulan Wigati, Kristanti Wanito