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All Journal Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML)
Fadhilatul Hilda
Medical Profession Program, Faculty of Medicine, Sriwijaya University, Palembang
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience

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C-Reactive Protein as The Predictor of Mortality for COVID-19 Patients in Indonesia Astari Rahayu Afifah; Phey Liana; Soilia Fertilita; Nelda Aprilia Salim; Verdiansah Verdiansah; Fadhilatul Hilda; Chris Alberto Amin; Tungki Pratama Umar
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 29 No. 2 (2023)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v29i2.1997

Abstract

Coronavirus Disease 2019 (COVID-19) confirmed cases and deaths continue to rise. When a virus infects the body, the immune system tries to eliminate the virus. C-Reactive Protein (CRP) is a substance produced in the body in response to infection and inflammation. The study aimed to determine the role of CRP in predicting COVID-19 patients’ mortality. From the 1st of March to the 31st of August 2020, data on patients confirmed with COVID-19 were collected from medical records. The correlation between CRP levels and patient mortality was determined using a Chi-Square test. A Receiver Operator Curve (ROC) analysis was used to determine the best CRP cut-off point, and a survival analysis was used to assess the patient outcome. This study included a total of 210 eligible patients. Survivors and non-survivors were divided into two groups of patients (159 patients and 51 patients, respectively). The CRP cut-off was 54 mg/L, with an AUC of 0.817 (p<0.001). C-reactive protein levels were related to COVID-19 patient mortality (p=0.000). According to the survival analysis, patients with CRP levels > 54 mg/L had a lower chance of 30-day survival (p=0.0001). This study presented that CRP levels can be used to predict mortality in COVID-19 patients.
Co-Authors Astari Rahayu Afifah Chris Alberto Amin Nelda Aprilia Salim Phey Liana Soilia Fertilita Tungki Pratama Umar Verdiansah Verdiansah