Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML)
Vol. 29 No. 2 (2023)

C-Reactive Protein as The Predictor of Mortality for COVID-19 Patients in Indonesia

Astari Rahayu Afifah (Medical Profession Program, Faculty of Medicine, Sriwijaya University, Palembang)
Phey Liana (Clinical Pathology Department, Faculty of Medicine, Universitas Sriwijaya, Palembang, Indonesia)
Soilia Fertilita (Department of Histology, Faculty of Medicine, Sriwijaya University, Palembang)
Nelda Aprilia Salim (Department of Internal Medicine, Faculty of Medicine, Sriwijaya University)
Verdiansah Verdiansah (Department of Clinical Pathology, Faculty of Medicine, Sriwijaya University/Dr. Mohammad Hoesin General Hospital, Palembang)
Fadhilatul Hilda (Medical Profession Program, Faculty of Medicine, Sriwijaya University, Palembang)
Chris Alberto Amin (Medical Profession Program, Faculty of Medicine, Sriwijaya University, Palembang)
Tungki Pratama Umar (Medical Profession Program, Faculty of Medicine, Sriwijaya University, Palembang)



Article Info

Publish Date
31 Mar 2023

Abstract

Coronavirus Disease 2019 (COVID-19) confirmed cases and deaths continue to rise. When a virus infects the body, the immune system tries to eliminate the virus. C-Reactive Protein (CRP) is a substance produced in the body in response to infection and inflammation. The study aimed to determine the role of CRP in predicting COVID-19 patients’ mortality. From the 1st of March to the 31st of August 2020, data on patients confirmed with COVID-19 were collected from medical records. The correlation between CRP levels and patient mortality was determined using a Chi-Square test. A Receiver Operator Curve (ROC) analysis was used to determine the best CRP cut-off point, and a survival analysis was used to assess the patient outcome. This study included a total of 210 eligible patients. Survivors and non-survivors were divided into two groups of patients (159 patients and 51 patients, respectively). The CRP cut-off was 54 mg/L, with an AUC of 0.817 (p<0.001). C-reactive protein levels were related to COVID-19 patient mortality (p=0.000). According to the survival analysis, patients with CRP levels > 54 mg/L had a lower chance of 30-day survival (p=0.0001). This study presented that CRP levels can be used to predict mortality in COVID-19 patients.

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Journal Info

Abbrev

patologi

Publisher

Subject

Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience

Description

Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) is a journal published by “Association of Clinical Pathologist” professional association. This journal displays articles in the Clinical Pathology and Medical Laboratory scope. Clinical Pathology has a couple of ...