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Peroneal Nerve Function and Knee Stability after Resection Giant Cell Tumour of Proximal Fibula, A Serial Case Mustaqim, Warih Anggoro; Isma, Satria Pandu Persada; Irsan, Istan Irmansyah
Berkala Kedokteran Vol 14, No 1 (2018)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v14i1.4588

Abstract

Abstract: Giant-cell  Tumour (GCT ) is a benign Tumour, locally aggressive neoplasm which is composed of sheets of neoplastic oviod mononuclear cells uniformly distributed large, osteoclast like giant cell. Incidence GCT of proximal fibula is rare. Peroneal nerve function and stability of knee joint must be considered at the proximal fibula GCT. In 2017 we found three cases of GCT of the proximal fibula in the outpatient clinic Saiful Anwar General Hospital. All three of these patients had a confirmed GCT of proximal fibula  which planned for Tumour resection, peroneal nerve presevation and LCL ligament reconstruction. This is study of three patients with  GCT of proximal fibula was confirm with Clinical Pathological Confrence (CPC). All of patient had presented of lump,  slowly growing pain in lateral side of knee, limping when they walk and numbness in dorsal side of foot. One patient cannot dorsoflexion of ankle. We evaluated a peroneal nerve function and stability of knee after operation and one year after resection of tumour. All patient had occurred peroneal nerve lesion with no instability of knee post operatively. Two patient had complaint with numbness in dorsal side of foot and weakness ankle dorsoflexion and after one year both of patient had improved ankle dorsoflexion but still numbness in dorsal side of foot. One patient  still complaining numbness in dorsal side of foot and weakness ankle dorsoflexion post operation and one year after operation. There is no LCL ligament instability  in all of patient post operation and one year after operation. The peroneal nerve function and LCL ligament stability must consider when facing benign tumours in proximal fibula such as giant cell tumour proximal fibula. These resections result in an unavoidable loss of knee stability because of resecting the lateral collateral ligament (LCL) insertion site on the fibular head. Based on the literature, the incidence rate of postoperative peroneal nerve palsy ranges from 3% to 57%. Giant cell tumour in proximal fibula is rare and require wide excision with intraarticular resection of the proximal tibiofibular join. We must consider about peroneal nerve function and LCL ligament stability during resection of GCT proximal fibula. Keywords: Giant Cell Tumour Proximal Fibula, Peroneal Nerve function, LCL Ligament stability
Skrining Tanaman Obat yang Berpotensi Sebagai Antioksidan In Vitro Kristanto, Adi; Mustaqim, Warih Anggoro; Suhartono, Eko; Qamariah, Nur
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 4, No 1 (2004)
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mmjkk.v4i1.1707

Abstract

Brotowali (Tinospora crispa [L] miers), bitter melon (Momordica charantia), and madagascar periwinkle (Catharanthus rosesus [L.] G. Don) are plants that have been used for some disease treatments. The mechanism of action of these plants to cure some diseases corellate with the balance of oxidant and antioxidant. To prove that statement, this study was conducted to evaluate the of antioxidant potential activity in these plants. The method used was antioxi¬dant trial activity with modification of DNP method. The result showed that Madagascar periwinkle (Catharanthus rosesus [L.] G. Don) infusion has the highest antioxidant activity, that was 90, 27%.Tanaman brotowali (Tinospora crispa [L] miers), pare {Momordica charantia), dan tapak dara {Catharanthus rosesus [L.] G. Don) adalah beberapa tanaman yang telah banyak dipergunakan untuk mengobati berbagai macam penyakit. Mekanisme tanaman tersebut dalam mengobati penyakit diduga terkait dengan keseimbangan antara oksidan dan antioksidan. Untuk membuktikan hal tersebut, maka dilakukan penelitian untuk mengetahui potensi aktivitas antioksidan tanaman brotowali, pare, dan tapak dara. Metode yang dipakai berupa pengujian aktivitas antioksidan dengan metode DNP yang dimodifikasi. Hasil penelitian menunjukkan bahwa infus daun tanaman tapak dara {Catharanthus rosesus [L.] G. Don) mempunyai aktivitas antioksidan paling baik, yaitu 90,27 %.