Article Per Year (5 Year)
p-Index From 2019 - 2024
0
P-Index
This Author published in this journals
All Journal Universa Medicina Cermin Dunia Kedokteran
Nurul Windi Anggraini, Nurul Windi
Unknown Affiliation
Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
Malondialdehyde levels are higher and glutathione levels are lower in preeclampsia than in normal pregnancies Subandrate, Subandrate; Faisal, Mia Esta Poetri Afdal; Anggraini, Nurul Windi; Sinulingga, Sadakata
Universa Medicina Vol 36, No 3 (2017)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2017.v36.179-186

Abstract

BackgroundMaternal mortality rate is still a health problem in Indonesia. One major contributor to maternal mortality rate in Indonesia is preeclampsia. One widely accepted theory is that preeclampsia is caused by oxidative stress. Placental hypoxia or ischemia among preeclampsia patients is thought to be the cause of the formation of free radicals such as malondialdehyde (MDA), which decreases endogenous antioxidants such as glutathione (GSH). This study aims to ascertain the difference in plasma malondialdehyde and glutathione levels between healthy and preeclamptic pregnant women.MethodsThis was an observational analytic study of cross sectional design. Research subjects were 30  normal (healthy) pregnant women (NP), and 30 pre-eclamptic pregnant (PE) women. The measurement of plasma MDA and GSH levels was done at the Biochemistry and Molecular Biology laboratories, Faculty of Medicine, Sriwijaya University using Sigma-Aldrich MDA and GSH assay kits. Mann Whitney test was used to analyze the data. ResultsSubjects aged >35 years, with age of gestation >35 weeks and multipara was significantly higher in the PE group compared to the NP group (p=0.016; p=0.01 and p=0.36; respectively). MDA level was significantly higher in the PE group than in the NP group (p=0.002). In contrast, GSH level was significantly lower in the PE group than in the NP group (p=0.003).ConclusionMDA and GSH may reflect vascular complications of PE, and the ensuing increases in lipid peroxidation may play important pathogenic roles.
Peranan Stres Oksidatif pada Preeklampsi -, Subandrate; Faisal, Mia EPA; Anggraini, Nurul Windi
Cermin Dunia Kedokteran Vol 44, No 6 (2017): Dermatologi
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (511.67 KB) | DOI: 10.55175/cdk.v44i6.800

Abstract

Preeklampsi merupakan sindrom pada kehamilan yang ditandai dengan peningkatan tekanan darah dan proteinuri. Salah satu teori patofisiologi preeklampsi adalah teori stres oksidatif. Stres oksidatif bermula dari kegagalan invasi trofoblas saat implantasi sehingga menyebabkan hipoksi atau iskemik plasenta, selanjutnya menyebabkan berbagai kerusakan sel termasuk disfungsi sel endotel plasenta. Disfungsi sel endotel plasenta bersama kerusakan sel lain memicu manisfestasi klinis preeklampsi.Preeclampsia is pregnancy-related syndrome characterized by high blood pressure and protenuria. According to oxidative stress theory, preeclampsia is started by failure of trophoblast invasion in implantation process causing placental hypoxia or ischemia. These conditions will lead to different mechanisms of cell damage, including placental endothelial cell dysfunction. Endothelial placental cell dysfunction and other cell damage caused by oxidative stress will trigger the clinical manifestations of preeclampsia.
Co-Authors Faisal, Mia EPA Mia Esta Poetri Afdal Faisal, Mia Esta Poetri Afdal Sadakata Sinulingga Subandrate