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All Journal JURNAL GIZI INDONESIA Journal of Nutrition College Universa Medicina
Edward Kurnia Setiawan Limijadi, Edward Kurnia Setiawan
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Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Prothrombine and activated partial thromboplastin time are prolonged in hepatic cirrhosis Limijadi, Edward Kurnia Setiawan; Suromo, Lisyani Budi; Budiwiyono, Imam
Universa Medicina Vol 35, No 1 (2016)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2016.v35.26-32

Abstract

BackgroundChronic hepatitis and hepatic cirrhosis are chronic liver diseases that cause disorders of liver function, such as the formation of platelets and coagulation factors (prothrombin time/PT and activated partial thromboplastin time/APTT). Chronic hepatitis in the long term can develop into hepatic cirrhosis. The aim of this study was to determine platelet count, PT, and APTT as indicators in the progression of chronic hepatitis towards hepatic cirrhosis. MethodsA cross-sectional study was conducted on 50 patients with chronic hepatitis and hepatic cirrhosis in Semarang City Regional General Hospital, Telogorejo Hospital and Kariadi General Hospital. The platelet count was measured with a Sysmex XP-100, while PT and APTT was measured with a Sysmex CA-1500 coagulometer. The Mann Whitney test was applied to analyze the difference in platelet count, PT, and APTT between chronic hepatitis and hepatic cirrhosis. Results Median, minimum, and maximum values of platelet count, PT and APTT in chronic hepatitis were 284.000/µl, 210.000/µl, 390.000/µl; 10.6 sec, 9.5 sec, 13.6 sec; and 30.5 sec, 24.2 sec, 46.4 sec, respectively, and in hepatic cirrhosis they were 96.300/µl, 48.200/µl, 133.800/µl; 27.5 sec, 11.9 sec, 44.7 sec; and 55.6 sec, 31.3 sec, 72.0 sec, respectively. There was a significant difference the reduction of platelet count, and the prolongation of PT and APTT in chronic hepatitis compared to hepatic cirrhosis (p=0.000). ConclusionsProthrombine time and APTT were prolonged and platelet count was decreased in hepatic cirrhosis subjects. The three parameters may be used to evaluate the progression of chronic hepatitis towards hepatic cirrhosis.
Correlation between HbA1c level and monocyte percentage in obesity Limijadi, Edward Kurnia Setiawan; Hendrianingtyas, Meita
Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) Vol 8, No 1 (2019)
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (298.001 KB) | DOI: 10.14710/jgi.8.1.75-78

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Background : HbA1c is one of the parameters that can be useful for diagnosing diabetes mellitus that can occur in obesity. Monocyte as an inflammatory cell is widely studied in relation to diabetes mellitus and obesity. The purpose of this study is to analyze the correlation between HbA1c levels and monocyte percentage in obesity.Methods : A Cross-sectional study of 30 medical students at a private laboratory in Semarang on March – April 2017 was done. The monocyte percentage included incomplete blood count was examined with the Sysmex XS-800i hematology analyzer, while HbA1c level was examined with Hemocue HbA1c 501 System. Spearman test was done for analyzing data with p <0.05 was considered statistically significant. Result and discussion : Median of HbA1c level was 5.8 ± 0.23%. Medians of leukocyte count, lymphocyte percentage, neutrophil percentage, and monocyte percentage were 8,600 ± 339,77 /μl, lymphocyte percentage 33% ± 1.19%, neutrophil percentage 56% ± 1.35%, and monocyte percentage of 9.0% ± 0.26%, respectively. Spearman test showed that correlation value (r) was 0.131 (p = 0.489).Conclusion and suggestion : There was no correlation between HbA1c levels and monocyte percentage in obesity. The increased of monocyte percentage can be used as monitoring and evaluation parameters in obesity that can lead to diabetes mellitus. Further study can be done in an obese population with older age as well as other parameters related to obesity and diabetes mellitus.
HUBUNGAN HbA1c DENGAN CRP PADA PENDERITA DIABETES MELITUS TIPE-2 DENGAN OBESITAS DAN TANPA OBESITAS Permatasari, Narulita Dyah; Rachmawati, Banundari; Riansari, Anugrah; Limijadi, Edward Kurnia Setiawan
Journal of Nutrition College Vol 9, No 4 (2020): Oktober
Publisher : Departemen Ilmu Gizi, Fakultas Kedokteran, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jnc.v9i4.29011

Abstract

Latar belakang: Diabetes melitus merupakan penyakit inflamasi kronis yang ditandai dengan peningkatan kadar glukosa plasma. Kadar glukosa plasma yang tinggi dalam jangka waktu lama (hiperglikemia kronik), menstimulasi peningkatan kadar C-reactive protein (CRP). Penderita DMT2 dengan obesitas kemungkinan memiliki kadar CRP yang lebih tinggi karena penumpukan sel adiposa juga dapat memicu reaksi inflamasi di dalam tubuh. Mengetahui hubungan antara obesitas, DMT2, dan kadar CRP sangat diperlukan untuk tujuan klinis serta mencegah terjadinya komplikasi penyakit.Tujuan: Tujuan dari penelitian ini adalah untuk menganalisis hubungan antara kadar HbA1c dan CRP pada penderita diabetes melitus tipe 2 dengan obesitas dan tanpa obesitasMetode: Penelitian observasional analitik dengan pendekatan belah lintang dilakukan di Rumah Sakit Nasional Diponegoro dan beberapa klinik pratama di Semarang pada Mei-Juli 2020. Subjek penelitian adalah 30 penderita diabetes melitus tipe 2 dengan obesitas dan 30 penderita diabetes melitus tipe 2 tanpa obesitas usia 35-60 tahun Pengukuran kadar HbA1c dan CRP dilakukan menggunakan alat ichroma metode fluorescence immunoassay (FIA). Analisis statistik untuk menguji normalitas data menggunakan Shapiro wilk test, Independent t test dilakukan untuk mengetahui perbedaan rerata karakteristik antara kelompok obesitas dan non-obesitas, dan Spearman Rank digunakan untuk melihat korelasi antara HbA1c dengan kadar CRP.Hasil:  Tidak ada korelasi antara kadar HbA1c dengan CRP pada penderita diabetes melitus tipe 2 dengan obesitas p = 0.420, r = 0,153 dan tanpa obesitas yaitu p= 0,182, r = 0,250.Simpulan: Kadar CRP yang terjadi pada pasien diabetes mellitus tipe 2 dimana inflamasi berjalan kronis tidak dipengaruhi oleh tingginya HbA1c baik pada kondisi obesitas maupun tidak obesitas.
Co-Authors Banundari Rachmawati Imam Budiwiyono, Imam Lisyani Budi Suromo, Lisyani Budi Meita Hendrianingtyas Permatasari, Narulita Dyah Riansari, Anugrah