Article Per Year (5 Year)
p-Index From 2019 - 2024
0
P-Index
This Author published in this journals
All Journal Pharmaceutical Sciences and Research (PSR)
Rangga Pradana, Rangga
Departemen Farmasi Universitas Indonesia

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
Formulasi Tablet salut Teofilin Menggunakan Eksipien Koproses Pregelatinisasi pati Singkong- Metilselulosa sebagai bahan Penyalut Pradana, Rangga; Chaidir, Chaidir; Anwar, Effionora
Majalah Ilmu Kefarmasian Vol. 7, No. 1
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Pregelatinized cassava star ch (PCS) is a physically modified starch. The purposes of the study were to improve functionality of PCS with making coprocess composed of PCS and methylcellulose (MC) by proportionally variation, which are 2:1, 3:1, and 4:1, as well as to applied co-processed excipient that could retard the drug release as coating material of theophylline tablet. Coprocessed excipient were characterized in terms of morphology, particle size distribution, compressibility index, flow rate and angle of repose, thermal analysis, hygroscopicity, gel strength, swelling test, and moiety analysis. Theophylline tablet that coated by PCS, MC, and co-processed PCSMC ratio (4:1) characterized and in vitro drug release were made in chloride medium of pH 1,2 and phosphate medium of pH 7,2. The characterization result of co-processed PCS-MC showed the improvement of functionality from PCS and synergism PCS with MC. Meanwhile, the result of in vitro drug release showed theophylline tablet that coated by MC 1%, co-processed PCS-MC (4:1) 4% and 2% could retard the drug release in both medium.
Eksipien Koproses Pregelatinisasi Pati Singkong Metilselulosa sebagai Bahan Penyalut Tablet Pradana, Rangga; Anwar, Effionora; Chaidir, Chaidir
Majalah Ilmu Kefarmasian Vol. 7, No. 3
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Coating is one of the effective methods used in controlled release dosage form. Lots of variety in the form of a hydrophilic polymer excipient that is used to control the drug release many polymers that can be used for coating purposes, but only a few have been known to serve as a polymeric coating which functions to control the rate of drug release Pregelatinized cassava starch (PCS) is a physically modified starch. The purposes of the study were to improve functionality of PCS with making coprocess composed of PCS and methylcellulose (MC) by proportionally variation, which are 2:1, 3:1, and 4:1, as well as to applied co-processed excipient that could retard the drug release as coating material of theophylline tablet. Coprocessed excipient characterized in terms of morphology, particle size distribution, compressibility index, flow rate and angle of repose, thermal analysis, hygroscopicity, gel strength, swelling test, and moiety analysis.
Co-Authors Chaidir Chaidir Effionora Anwar