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Pembuatan Sediaan Tablet Mengapung Famotidin Menggunakan Kompleks Polielektrolit Kitosan-Pektin Sebagai Bahan Matriks Erny Sagita; Effionora Anwar; Silvia Surini
PSR (Pharmaceutical Sciences and Research) Vol 8, No 1 (2011)
Publisher : Fakultas Farmasi Universitas Indonesia

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Abstract

Floating tablet is one of the drug delivery system retained in the stomach which aims to prolong the lag time of the drug in the stomach. This principle can be used to improve the efficacy of famotidine in treating diseases in the stomach The purpose of this research is to develop dosage form afloat by using Chitosan Pectin Electrolytes (PEC) as matrix then used as the matrix in tablet dosage form with famotidine as a drug model. PEC also combined with hydroxypropylmethylcellulose (HPMC) with different. PEC was also combined with hydroxypropilmethylcellulose (HPMC) in different concentrations. The results of the dissolution study showed that PEC could retard the release of famotidin for 10 hours. PEC in combination with HPMC could retard the release of famotidin for 20 hours. Tablet that only contains PEC as matrix could remain buoyant for 12 hours while tablet with combination of PEC and HPMC could remain buoyant for 24 hours.Keywords: Famotidine, chitosan, polyelectrolite complex, pectin, floating tablet
FORMULASI GEL MENGGUNAKAN SERBUK DAGING IKAN HARUAN (Channa striatus) SEBAGAI PENYEMBUH LUKA Rahmawanty, Dina; Anwar, Effionora; Bahtiar, Anton
Media Farmasi: Jurnal Ilmu Farmasi Vol 11, No 1: Maret 2014
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (4147.172 KB) | DOI: 10.12928/mf.v11i1.1395

Abstract

Daging  ikan  haruan  (Channa  striatus)  dipercaya  dapat  digunakan  untuk menyembuhkan  luka  karena  mengandung  protein,  asam  amino  esensial,  lemak dan  asam  lemak  yang  berperan  dalam  proses  penyembuhan  luka.  Tujuan  dari penelitian  ini  ialah  membuat  gel  yang mengandung  serbuk  daging  ikan  haruan sebagai penyembuh luka. Pada penelitian ini digunakan serbuk daging ikan haruan (Channa striatus) sebagai zat aktif sebanyak 1 gram pada formula 1 dan 2 gram pada  formula  2.  Serbuk  daging  ikan  haruan  dibuat  suspensi  dengan  ukuran partikel nanometer dengan metode gelasi ionik menggunakan kitosan dan natrium tripolifosfat,  kemudian  dibuat  menjadi  bentuk  sedian  gel  dengan  menggunakan gelling agentHPMC. Suspensi yang dihasilkan dilakukan karakterisasi fisika dan kimia. Hasil karakterisasi suspensi formula 1 dan formula 2 adalah sebagai berikut :  ukuran  partikel  berturut-turut  491,8  -  665,5  nm,  481,8  – 828,1  nm;  indeks polidispersitas 0,512, 0,456; nilai potensial zeta (+)29,15mV, (+)29,35mV; kedua formula  mempunyai  partikel  berbentuk  sferis.  Sediaan  gel  yang  dihasilkan dievaluasi  aktivitas  penyembuhan  luka  secara  in  vivo.  Dari  hasil  uji  in  vivo sediaan gel serbuk daging ikan haruan dapat digunakan sebagai penyembuh luka. Kata  Kunci:  gel,  gelasi  ionik,  haruan  (Channa  striatus),  kitosan,  natrium tripolifosfat, luka.
STUDI KEMAMPUAN NIOSOM YANG MENGGUNAKAN MALTODEKSTRIN PATI GARUT (Maranta arundinaceae Linn.) SEBAGAI PEMBAWA KLORFENIRAMIN MALEAT Effionora Anwar; Henry .; Mahdi Jufri
Makara Journal of Science Vol 8, No 2 (2004): Agustus
Publisher : Directorate of Research and Community Engagement, Universitas Indonesia

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Abstract

Study ofthe Capability of Niosomes that Used Maltodextrin from Garut Starch (Maranta arundinaceae Linn.) as a Chlorpheniramine Maleate Carrier. The aim of this research was to study the entrapment ability of ampiphylic drug, chlorpheniramine maleate (CTM), by niosome. Like liposomes, niosomes is an encapsulated drug carrier that hasimportant role in a drug release system. Niosomes and liposomes are unstable, but niosomes could be handled byproniosomes. Proniosomes in this research was prepared using the combination of maltodextrin DE 5-10 from arrowroot starch (Maranta arundinaceae Linn.), Span 60 and Cholesterol as non ionic surfactant in six formulas. The entrapment level of CTM depends on combination of surfactant in proniosomes, drug substance concentration and proniosomes quantity, temperature, and hydration times. Niosomes (10mM) that was prepared by proniosomes in formula 3 has been hydrated at 80 oC for 2 minutes using demineralized water could entrapped 94,04%, of 1 mM CTM. The proniosomes in formula 3 was increased up to 30 mM surfactant and 10 mM CTM in niosomes, could increase the entrapment of CTM.Keywords: Niosomes, non ionic surfactant, maltodextrin DE 5-10.
Pemanfaatan Maltodekstrin Dari Pati Singkong Sebagai Bahan Penyalut Lapis Tipis Tablet Effionora Anwar
Makara Journal of Science Vol 6, No 1 (2002): April
Publisher : Directorate of Research and Community Engagement, Universitas Indonesia

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Abstract

The Use of Maltodextrin from Tapioca Starch as a Film Coating Tablet Material. Maltodexrin is a modifi ed starch productwhich can be use as a material fi lm coating tablet. The aim of the research was to study the capability of maltodextrin asa material fi lm coating exipient. Maltodextrin DE 5-10 was made by hidrolysis of tapioca starch with α-amylase enzymefrom NOVO (Termamyl L120®), at 80° C, for 65 minute. Maltodextrin was used as a fi lm coating material at concentration10%,15%,20% dan 25%. As a comparative fi lm coating material was used HPMC. The evaluation of the coating tabletwas done accordance to Farmacope Indonesia third and fourth edition. The result show that maltodextrin DE 5-10 fromtapioca starch can be used as fi lm coating at concentration 10-25% with concentration 10% gave better result a HPMC.
Preparation and Characterization of Co-Processed Excipient Carrageenan-Pregelatinized Cassava Starch Propionate as a Matrix in The Gastroretentive Dosage Form Effionora Anwar; Engkom Komariah; Junaedi Junaedi
Makara Journal of Science Vol 15, No 2 (2011): November
Publisher : Directorate of Research and Community Engagement, Universitas Indonesia

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Abstract

The gastroretentive dosage form is designed to prolong the gastric residence time of the drug delivery system which also results in the development of an appropriate excipient. The purpose of this study is to develop and characterize coprocessed excipient made from carrageenan (kappa-iota = 1:1) and pregelatinized cassava starch propionate (PCSP) in ratios of 1:1, 1:2, and 1:3. PCSP was prepared with propionic anhydride in an aqueous medium. The product was mixed with carrageenan (kappa-iota = 1:1), as well as characterized physicochemical and functional properties. The coprocessed excipient was then used as a mucoadhesive granule and floating tablet. The USP Basket was selected to perform the dissolution test of the granules in HCl buffer (pH 1.2) and distilled water for 8 hours each. Mucoadhesive properties were evaluated using bioadhesive through a vitro test and wash-off test. As for the floating tablet, the USP Paddle was selected to perform the dissolution test of the tablets in 0.1 N HCl for 10 hours. The floating lag time and floating time were tested in 0.1 N HCl for 24 hours. The result of these studies indicated that co-processed excipient carrageenan-PCSP can retard dosage form in gastric and drug controlled release, thus making it a suitable material for the gastroretentive dosage form.
Formulasi Tablet salut Teofilin Menggunakan Eksipien Koproses Pregelatinisasi pati Singkong- Metilselulosa sebagai bahan Penyalut Rangga Pradana; Chaidir Chaidir; Effionora Anwar
Pharmaceutical Sciences and Research (PSR) Vol 7, No 1 (2010)
Publisher : Directorate of Research and Community Engagement, Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1286.665 KB) | DOI: 10.7454/psr.v7i1.3450

Abstract

Pregelatinized cassava starch (PCS) is a physically modified starch. The purposes ofthe study were to improve functionality of PCS with making coprocess composed ofPCS and methylcellulose (MC) by proportionally variation, which are 2:1, 3:1, and4:1, as well as to applied co-processed excipient that could retard the drug release ascoating material of theophylline tablet. Coprocessed excipient were characterized interms of morphology, particle size distribution, compressibility index, flow rate andangle of repose, thermal analysis, hygroscopicity, gel strength, swelling test, andmoiety analysis. Theophylline tablet that coated by PCS, MC, and co-processed PCSMCratio (4:1) characterized and in vitro drug release were made in chloride mediumof pH 1,2 and phosphate medium of pH 7,2. The characterization result of co-processedPCS-MC showed the improvement of functionality from PCS and synergismPCS with MC. Meanwhile, the result of in vitro drug release showed theophyllinetablet that coated by MC 1%, co-processed PCS-MC (4:1) 4% and 2% could retardthe drug release in both medium.Keywords : co-prosses, pregelatinized cassava starch, methylcellulose, theophylline,coated tablet.
Eksplorasi dan Karakterisasi berbagai Kristal Ibuprofen Arry Yanuar; Nursanti Nursanti; Effionora Anwar
Pharmaceutical Sciences and Research (PSR) Vol 7, No 2 (2010)
Publisher : Directorate of Research and Community Engagement, Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (706.615 KB) | DOI: 10.7454/psr.v7i2.3455

Abstract

Ibuprofen is an analgesic anti-inflammatory nonsteroidal (AINS). Generally, ibuprofenhave a bad flowability because a high cohesivity. Another problem in manufacturingis the high tendency for sticking to the punches. Besides these disadvantageous properties,ibuprofen indicates bad dissolution behavior because of its hydrophobic structure.To improve the properties of ibuprofen can be used crystallization method withusing variation of solvents. In this experiment observed crystallization method bycooling, evaporation, and water presence, which used methanol, ethanol, and acetonesolvents. Of all the crystallization results are produced white prism-shaped crystalline.The selected method is cooling method, which is characterized using ScanningElectron Microscopy (SEM), powder X-ray diffraction, and Differential ScanningCalorimetry (DSC). These three characterizations indicate transformation of crystalform which compared with ibuprofen’s standard. The selected method also producesnon cohesive powder which have the size particle is 710-1180µm, compressibilityindex: IBMD 14.2%, IBED 16.6%, IBAD 17.1%; angles of repose: IBMD 28.1º,IBED 29.7º, IBAD 30.1º, and have higher solubility than the common crystal’ssolubility. The result indicates that crystallization method is able to improve flowrate,compressibility index, and dissolution rate properties of ibuprofen’s standard.Keywords : Ibuprofen, Crystal habit, Polymorphism, Crystallization techniques.
UJI STABILITAS SEDIAAN MIKROEMULSI MENGGUNAKAN HIDROLISAT PATI (DE 35–40) SEBAGAI STABILIZER Mahdi Jufri; Effionora Anwar; Putri Margaining Utami
Pharmaceutical Sciences and Research (PSR) Vol 3, No 1 (2006)
Publisher : Directorate of Research and Community Engagement, Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (53.057 KB) | DOI: 10.7454/psr.v3i1.3396

Abstract

Various solubilization techniques have been developed to enhance the bioavailability of hydrophobic drugs. One of the solubilization techniques is preparation of microemulsion. Microemulsion is a potential carrier in drug delivery system because it has many advantageous characteristics. In this research, hydrophobic drug was made in a dosage form of oil in water (O/W) microemulsion using ketoprofen as a model and investigated the influence of adding starch hydrolisates with dextrose equivalent (DE) 35-40 in variety concentrations (0,0%; 1,5%; 2,0%; 2,5%) to the stability of this microemulsion system. This microemulsion consisted of isopropyl miritate as oil phase, tween 80 and lechitin as surfactants, ethanol as cosurfactant, propylene glycol as cosolvent, starch hydrolisates DE 35–40 as stabilizer, and water as external phase. The evaluation was stability test both phisically and chemically. The result showed that the stability of microemulsion system increased significantly by adding starch hydrolisates DE 35-40 at 2,5%. Key words: microemulsion, ketoprofen, starch hydrolisates
Pembuatan Sediaan Tablet Mengapung Famotidin Menggunakan Kompleks Polielektrolit Kitosan-Pektin Sebagai Bahan Matriks Erny Sagita; Effionora Anwar; Silvia Surini
Pharmaceutical Sciences and Research (PSR) Vol 8, No 1 (2011)
Publisher : Directorate of Research and Community Engagement, Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1109.014 KB) | DOI: 10.7454/psr.v8i1.3471

Abstract

Floating tablet is one of the drug delivery system retained in the stomach which aims to prolong the lag time of the drug in the stomach. This principle can be used to improve the efficacy of famotidine in treating diseases in the stomach The purpose of this research is to develop dosage form afloat by using Chitosan Pectin Electrolytes (PEC) as matrix then used as the matrix in tablet dosage form with famotidine as a drug model. PEC also combined with hydroxypropylmethylcellulose (HPMC) with different. PEC was also combined with hydroxypropilmethylcellulose (HPMC) in different concentrations. The results of the dissolution study showed that PEC could retard the release of famotidin for 10 hours. PEC in combination with HPMC could retard the release of famotidin for 20 hours. Tablet that only contains PEC as matrix could remain buoyant for 12 hours while tablet with combination of PEC and HPMC could remain buoyant for 24 hours.Keywords: Famotidine, chitosan, polyelectrolite complex, pectin, floating tablet
Pembuatan Matriks dari Kompleks Polielektrolit Kitosan Pektin untuk Sediaan Tablet Mengapung Erny Sagita; Effionora Anwar; Silvia Surini
Pharmaceutical Sciences and Research (PSR) Vol 7, No 3 (2010)
Publisher : Directorate of Research and Community Engagement, Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1477.643 KB) | DOI: 10.7454/psr.v7i3.3462

Abstract

Chitosan is a natural cationic polymer. That cationic property makes chitosan canform polyelectrolite complex (PEC) with anionic polymer. In this research, pectinwas used as anionic polymer that interact ionically with chitosan. The aim of thisresearch is to produce and characterize chitosan-pectin PEC that would be used asmatrix in floating tablet. The solutions of chitosan and pectin 0,3% w/v were mixedin ratio 1:9, 3:7, 1:1, 7:3 and 9:1 with pH of the solution 4,5 and 5,0. The bestcondition to produce PEC was in pH 5,0 with ratio of chitosan and pectin = 3:7. Thedifferences between chitosan-pectin PEC characteristic and its origin polymer wereshown by functional group analysis, thermal analysis, swelling capacity and gelstrength. The PEC was then used as matrix in floating tablet.Keywords : chitosan, polyelectrolite complex, pectin, floating tablet