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All Journal Pharmacon Jurnal Ilmiah Manuntung Journal of Herbal, Clinical and Pharmaceutical Science (HERCLIPS)
Okpri Meila, Okpri
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Environmental Science Health Professions Medicine & Pharmacology Physics Public Health

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Kajian Drug Related Problems (DRPs) Terhadap Pengobatan Pasien Stroke Iskemik di Rumah Sakit Pusat Otak Nasional Jakarta Periode Januari – Desember 2015 S Meila, Okpri; Rochana, Handika Indri
Pharmacon: Jurnal Farmasi Indonesia Vol 14, No 2 (2017)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v14i2.5765

Abstract

This study aims to determine the percentage of DRPs of ptients with ischemic stroke at Brain Center National Hospital Jakarta. Based on data from the WHO 2006, each year there are approximately 13 million new stroke patients of which approximatelly 4,4 million of them die within 12 months.When patients undergo a treatment, most patients achieve optimal results that heal diseases suffered by patients but not least the failure in therapy. Therefore, the contribution required to identify, resolve and prevent problems in drug therapy known as Drug Related Problems (DRPs). The method used in this study is cross sectional. Total sample data obtained as many as 360 samples. The results showed indications without drugs of 55.62%, drugs without indication of 15.17%, drug interactions of 10.11%, patients fail to receive the drug of 7.86%, side effects of 6.18% and less drug selection right of 5.06%. Data show that the highest percentage of DRPs are indications without drugs.
Pengaruh Ekstrak Etanol Daun Murbei (Morus Alba L.) dengan Glibenklamid Terhadap Ekspresi Gen CYP3A4 pada Kultur Sel HepG2 Nuralih, Nuralih; Churiyah, Churiyah; Pambudi, Sabar; Tamat, Swasono R.; Meila, Okpri
Pharmacon: Jurnal Farmasi Indonesia Vol 15, No 1 (2018)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v15i1.5766

Abstract

Mulberry leaf is a traditional herb and predicted has ecdysteronecompound which act as antihyperglicemid. Glybenclamide is a synthetic medicine used to cure diabetes mellitus type 2. The leaf reported as competitive inhibitor of CYP3A4 enzyme, which metabolizingglibenclamide. However, in many cases, combination of herbs with synthesis drugs causes interaction if used at the same time. This research aimed to see interaction of ethanol mulberry leaf extract with glibenclamide through CYP3A4 gene expression in HepG2 cell culture.Sample of mulberry extract, glibenclamide, and combination both sample were tested into cell HepG2 culture. Then RNA were isolated and purification using real time PCR to see the gene CYP3A4 expression. As a result, mulberry extract acts as inhibitor enzyme CYP3A4, while glibenclamide is enzyme substrate.The combination of mulberry and glibenclamide showed increased of expression of CYP3A4 gene, means greater enzyme produced, and lower medicine on blood plasma.
Uji Aktivitas Antibakteri Sediaan Obat Kumur Dari Ekstrak Etanol 70% Batang Sambung Nyawa (Gynura procumbens (Lour.) Merr.) Terhadap Bakteri Streptococcus mutans Gurning, Dame; Nathaniel, Dicki; Meila, Okpri; Sagala, Zuraida
Pharmacon: Jurnal Farmasi Indonesia Vol 15, No 2 (2018)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v15i2.5880

Abstract

Karies gigi merupakan suatu masalah pada mulut yang disebabkan oleh bakteri Streptococcus mutans, prevalensi karies gigi telah mencapai hingga 60% di Indonesia. Penggunaan obat kumur dinilai efektif, karena dapat membersihkan mulut sampai ke sela-sela gigi. Pada penelitian ini dilakukan uji aktivitas antibakteri sediaan obat kumur dari ekstrak etanol batang sambung nyawa (Gynura procumbens (Lour.) Merr.) terhadap bakteri Streptooccus mutans dengan seri konsenterasi ekstrak 2,5%; 5% dan 10%. Pengujian aktivitas antibakteri dilakukan dengan menggunakan metode difusi cakram. Uji aktivitas antibakteri ekstrak batang sambung terhadap bakteri Streptococcus mutans dilakukan sebagai uji pendahuluan dan hasilnya didapatkan Konsenterasi Hambat Minimum (KHM) terhadap pertumbuhan bakteri Streptococcus mutans ada pada konsenterasi ekstrak 2,5% dengan rata-rata zona hambatan sebesar 7,80 mm. Rata-rata zona hambat terhadap pertumbuhan bakteri Streptococcus mutans lebih tinggi dalam sediaan obat kumur dibandingkan dengan bentuk ekstrak yang masih murni, dikarenakan adanya beberapa bahan pada formulasi sediaan obat kumur yang dapat berfungsi sebagai agen antibakteri, seperti gliserin, menthol dan natrium benzoat. Zona hambatan terhadap pertumbuhan bakteri Streptococcus mutans meningkat seiring dengan meningkatnya konsenterasi dari ekstrak etanol batang sambung nyawa. Data zona hambat pertumbuhan bakteri dianalisis menggunakan One Way ANOVA dengan taraf kepercayaan 95%. Evaluasi stabilitas dari sediaan obat kumur meliputi pemeriksaan organoleptis, homogenitas dan pH yang dilakukan selama empat minggu penyimpanan pada suhu ruang menunjukkan hasil yang stabil.
TINGKAT KEPUASAN PASIEN RAWAT JALAN TERHADAP PELAYANAN KEFARMASIAN DI INSTALASI FARMASI RUMAH SAKIT MARINIR CILANDAK JAKARTA Pontoan, Jenny; Meila, Okpri; Asnanik, Yuli; Muharam, Muhammad Azhar
Jurnal Ilmiah Manuntung Vol 6 No 1 (2020): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung akademi farmasi samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (279.701 KB)

Abstract

Measuring the quality dimensions of health service is essential and should be done along with patient satisfaction surveys. The level of patient satisfaction with hospital health services may use the five-dimensional Service Quality (ServQual) method, that is, reliability, responsiveness, assurance, concern and tangible form. The study was conducted to determine the level of outpatient satisfaction with the quality of services provided by The Cilandak Marinir Hospital Pharmacy Installation. The research design is Observational by survey methods, conducted on JKN outpatients, with a total sample of 106 respondents. Inclusion criteria; patients who redeem a prescription at a hospital pharmacy installation at least 2 times; patients who are willing to fill out the questionnaire, sign the questionnaire, and approve the informed consent; patients aged ? 15 years. Exclusion criteria are patients who are hospital employees; HIV / AIDS patients. This study was also complemented with data collection permits from the hospital and ethical approval from the ethics research committee of the Universitas Pembangunan Veteran Jakarta. The instrument used is in the form of a questionnaire to measure patient satisfaction about pharmacy services at the pharmacy. The results of the validity test of 0.383-0.950 (components of expectations) and 0.362-0.928 (components of performance) are declared valid. The reliability test results are 0.954-0.961 (expectation component) and 0.951-0.960 (performance component); these results indicate that the questionnaire can be used because all questions are reliable (> 0.60 Cronbach Alpha scores). Data analysis uses the Service Quality method (Service Quality score = Performance - Expectation). A positive score indicates that customer expectations are met so that services on specific dimensions can be perceived as high quality and vice versa. Ideally, the value of the gap between expectations and perceptions is zero. ServQual analysis results based on the gap showed that the most significant value of the gap in the dimensions of reliability -0.18, responsiveness (responsiveness) -0.12, awareness (empathy) -0.08, assurance -0, 07, and tangible form (tangible) -0.03. Based on these results, It can be concluded that pharmaceutical services still need improvement because they still have a negative gap value for the five dimensions.  
Analisis Tingkat Kepuasan Pasien BPJS Pada Pelayanan Kefarmasian Di Apotek Klinik SATKES PUSDOKKES MABES POLRI Meila, Okpri; Pontoan, Jenny; Zizwanto, , Eddy
Journal of Herbal, Clinical and Pharmaceutical Science (HERCLIPS) Vol 1 No 02 (2020): HERCLIPS VOL 01 NO 02
Publisher : Universitas Muhammadiyah Gresik

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30587/herclips.v1i02.1520

Abstract

Service satisfaction is achieved if what the patient gets exceeds what is expected. This study to determine the level of BPJS patient satisfaction and dimensions affect the level of satisfaction with pharmaceutical services provided in Drugstore Clinic Satkes Pusdokkes Headquarter Police. This reasearch was conducted the data of patients who were treated and carried out in cross sectional, by distribution questioner and analyzed descriptive. Reasearch subjects were teken by quota sampling technique. The level of satisfaction of this study was measured based on five dimensions of service quality and analyzed using percentase and likert scalet. The results of the showed that patients who were treated at the Drugstore Clinic Satkes Pusdokkes Headquarter Police were satisfied with the services provided by the services provided Keyword : Satisfaction level, pharmaceutical services, BPJS
Co-Authors Ahmad Fuad Afdhal Ani Rahayu Asnanik, Yuli CHURIYAH CHURIYAH Feriadi Suwarna Gurning, Dame Hasan, Delina Muharam, Muhammad Azhar Nathaniel, Dicki Nuralih Nuralih, Nuralih Pambudi, Sabar Pontoan, Jenny Rochana, Handika Indri Sagala, Zuraida Swasono R. Tamat Zizwanto, , Eddy