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Aswan Pangondian

Universitas Haji Sumatera Utara, Indonesia

Author-ID : 6257076

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Formulasi Dan Evaluasi Sediaan Lipstik Dari Ekstrak Buah Naga Merah (Hylocereus polyrhizus) Dan Ekstrak Lidah Buaya (Aloe vera) Sebagai Pewarna Dan Pelembab Alami Athaillah Athaillah; Dwi Sundari; Aswan Pangondian; Putra Chandra
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 1 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Red dragon fruit (Hylocereus polyrhizus) contains the chemical betacyanin, which functions as a natural dye, and aloe vera (Aloe vera) also has a polysaccharide derivative lignin which functions as a binder of skin moisture. The combination of red dragon fruit extract and aloe vera can be made as a pharmaceutical preparation in the form of lipstick. This study aimed to determine the optimum concentration of red dragon fruit extract and aloe vera on the physical properties of lipstick. This research is an experimental study with the stages of making extracts by maceration method with betacyanin phytochemical test on red dragon fruit and infundation method with a phytochemical test of lignin on aloe vera before making lipstick. Making lipstick with six variations of concentration of red dragon fruit extract 30,25,20,15,10,5% (w/v) and aloe vera 5,10,15,20,25,30% (w/v) and organoleptic test, homogeneity test, pH test, smear test, melting point test, hardness test, irritation test and tested the physical stability of lipstick preparation with a stability test of 3 cycles. The result of maceration on red dragon fruit was 57 ml, and aloe vera infundation was 57 ml. The results of the phytochemical test showed that the red dragon fruit extract was positive for betacyanin and the aloe vera extract was positive for lignin. The formula (F) in this study is concentration. The results showed that the concentration of red dragon fruit extract by an organoleptic test with Formula 1 (F1) to formula 6 (F6) produced good color, smell, and shape. The pH test results of all formulas have a pH below the standard range of skin pH, namely pH 8. The smear test results show that all formulas have good smearing power. The melting point test results show that formula 4 (F4) has a melting point of 66̊ C. The hardness test results showed that Formula 6 (F6) produces a strong textural power. The results of the irritation test showed that all of the formulas did not produce an itchy or swollen effect when applied successively for three days and the results of the stability test showed that formulas 3 (F3) to formula 6 (F6) produced discoloration such as drastic fading and melting texture at the bottom of the preparation happened on day 4 of being at extreme temperatures. The optimum lipstick formulation in the standard range is formula 1 (F1) with a concentration of 30% red dragon fruit and 5% aloe vera, which is quite good and can be formulated as a lipstick preparation.

POTENSI EKSTRAK BUNGA TELANG (Clitorea ternatea L.) TERHADAP ANTIDIABETES PADA MENCIT PUTIH JANTAN (Mus musculus) Aswan Pangondian; Robiatun Rambe; Chindy Umaya; Athaillah Athaillah; Kadriyani Jambak
FORTE JOURNAL Vol 3 No 2 (2023): Edisi Juli 2023
Publisher : Universitas Haji Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51771/fj.v3i2.630

Bunga telang (Clitoria ternatea), sering disebut juga sebagai butterfly pea merupakan bunga yang khas dengan kelopak tunggal berwarna ungu. Potensi farmakologi bunga telang antara lain adalah sebagai antioksidan, antibakteri, anti inflamasi dan analgesik, antiparasit dan antisida, antidiabetes, antikanker, antihistamin, dan potensi berperan dalam susunan syaraf pusat, Central Nervous System (CNS). Pada zaman dahulu kala, bunga ini dipakai sebagai tetes mata, baik pada bayi ataupun orang dewasa. Uji kadar gula darah pada mencit menggunakan Glucometer. Metode ini digunakan untuk menurunkan kadar gula darah pada mencit.25 ekor mencit dibagi menjadi 5 kelompok, masing-masing kelompok terdiri dari 5 ekor mencit. Kelompok pertama Metformin 65%, kelompok kedua Na-CMC 0,5%, kelompok ketiga ekstrak bunga telang 250%, kelompokkeempat 500%, kelompok kelima 1000%, masing-masing kelompok diberi perlakuan per oral selama 28 hari. Kemudiandiharike 0 diberikan suspense glukosa 50% secara oral, setelah itu pada hari ke 0 dilakukan pengambilan darah, dilanjutkan pada hari ke 7, 14, 21, dan hari ke 28. Kemudian kadar gula darah diukur menggunakan Glukometer, kemudian mencit diberi perlakuan sesuai kelompok yang sudah dibuat. Dihitung penurunan kadar gula darah.Hasil penelitian menunjukkan bahwa pemberian ekstrak bunga telang dosis 250 mg, 500 mg dan 1000 mg dapat menurunkan kadar gula darah pada mencit dibandingkan terhadap kontrol negatif (p < 0,05). Kelompok pemberian CMC Na 0,5% memiliki perbedaan yang signifikan dengan kelompok pemberian metformin (p<0,05) dan juga terdapat perbedaan dengan kelompok pemberian sediaan dosis 33 mg/KgBB, 65 mg/KgBB dan 130 mg/KgBB (p<0,05). Berdasarkan pemaparan di atas dapat disimpulkan bahwa Ekstrak bunga telang mempunyai potensi penurunan kadar gula darah pada mencit jantan, Ekstrak bunga telang 250 mg, 500 mg dan 1000 mg dapat meningkatkan potensi penurunan dibandingkan dengan kontrol CMC Na 0,5%. Ekstrak bunga telang mempunyai efek menghambat aktivitas enzim glukoneogenik, glukosa-6- fosfatase, dan sebaliknya meningkatkan aktivitas enzim glukokinase.

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