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All Journal JOPS (Journal Of Pharmacy and Science)
Salman Umar
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Preparasi dan Karakterisasi Sifat Fisikokimia Multikomponen Ketoprofen dengan Koformer Proline Helen Sonita; Salman Umar; Erizal Zaini
JOPS (Journal Of Pharmacy and Science) Vol 6 No 2 (2023): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v6i2.3485

Abstract

Ketoprofen is a non-steroidal anti-inflammatory compound (NSAID) which has low solubility in water. The aim of this study was to increase the dissolution rate of ketoprofen by forming multicomponent ketoprofen-Proline with ratio of 1:1, 1:2, and 2:1 by using solid state grinding method. Samples were characterized by Powder X-Ray Diffractometry (PXRD), Differential Scanning Calorimetry (DSC), Fourier Transform Infrared (FTIR) Spectroscopy, scanning electron microscope (SEM) analysis, solubility test, dissolution rate profile, and stability test. The results indicates the formation of a eutectic mixture of ketoprofen-Proline. From the study of the ketoprofen–proline eutectic mixture, the eutectic point in ratio 2:1 was obtained 54,763℃. The PXRD spectra did not form new crystal habit, the highest solubility test of the eutectic mixture of ketoprofen-proline showed an increase respectively 2,671 times in ratio 1:2. Stability test showed that ketoprofen-proline was not stable at 75% relative humidity (RH) 40℃ degree during 6 months storage because it deformed the solid phase into the liquid phase.
Co-Authors Erizal Zaini Helen Sonita