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Christian Manginstar
Universitas Sam Ratulangi
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Nursing Public Health

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Fibrocystic Breast Tumor: A Case Report Ferry Kalitouw; Christian Manginstar; Melfrits Siwabessy
Medical Scope Journal Vol. 5 No. 1 (2023): Medical Scope Journal
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/msj.v5i1.46215

Abstract

Abstract: Fibrocystic breast tumor is the most common benign type of breast diseases that affects millions of women worldwide. Fibrocystic breast changes are classified as non-proliferative, proliferative without atypia, or proliferative with atypia. We reported a 34-year-old woman presented with a right breast evaluation of breast tumors since one year before admission. On examination, a solid and hard breast tumor measuring 15x10 cm was palpable, well-defined, tender, mobile, and no nipple discharge. The patient underwent two times of core biopsy and the results were fibrocystic changes. Although clinically the breast tumor had a malignant appearance, but the results of core biopsy examinations revealed fibrocystic changes. The patient was managed by wide excision of the evaluated breast tumor with preservation of the breast skin and nipple areolar complex to maintain its function and aesthetic. In conclusion, evaluation of breast tumors must go through a triple diagnostic procedure namely clinical, imaging, and histopathological examinations. Fibrocystic breast tumor can be managed with wide excision of the tumor with preservation of the skin structure and nipple areolar complex of the breast to achieve a natural aesthetic. Keywords: fibrocystic breast tumor; wide excision of tumor; evaluation of breast tumors
Analisis Pemberian Propolis terhadap Kadar CA 15-3 Kasus Kanker Payudara Stadium Lanjut Filandy Pai; Christian Manginstar; Marselus Merung; Fredrik G. Langi
Medical Scope Journal Vol. 6 No. 1 (2024): Medical Scope Journal
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/msj.v6i1.48478

Abstract

Abstract: Breast cancer is the first rank of cancer incidence and the second mortality rate in Indonesia. Propolis is already known as a potential anticancer agent. This study aimed to evaluate the effect of propolis administration on CA 15-3 level in breast cancer patients. This was a quasi experimental study with a pre and post test design. Subjects were patients with advanced breast cancer at the Surgery-Oncology polyclinic and Surgery nursing room at Prof. Dr. R. D. Kandou Hospital Manado from June 2022 to March 2023. There were 20 patients with breast cancer in this study, divided into two groups (treatment and control groups) with age and cancer location. Data were analyzed with th independent t-test. The results showed that the increase of CA 15-3 level in treatment group was 8.3±3.5 U/mL meanwhile in the control group was 11.4±3.4 U/mL. There was no significant difference in the increased level of CA 15-3 in the two groups (p=0.069). In conclusion, propolis administration has descriptive effect on breast cancer patients with lower increase of CA 15-3 level compared to the control group, however, there is no significant difference between the two groups. Keywords: propolis; breast cancer; CA 15-3 marker   Abstrak: Kanker payudara menduduki peringkat pertama insidensi kanker dan angka mortalitas kedua di Indonesia. Propolis telah dikenal sebagai agen antikanker yang potensial. Penelitian ini bertujuan untuk mengevaluasi efek pemberian propolis terhadap kadar plasma CA 15-3 penderita kanker payudara. Penelitian ini menggunakan metode kuasi eksperimental pre dan post tes dengan desain potong lintang. Subjek penelitian ialah pasien kanker payudara stadium lanjut di Poliklinik Bedah-Onkologi dan Ruang Perawatan Bedah RSUP Prof. Dr. R. D. Kandou Manado sejak bulan Juni 2022 hingga Maret 2023. Jumlah subjek penelitian sebanyak 20 pasien, dibagi atas dua kelompok (kelompok uji dan kontrol) dengan data demografi usia dan lokasi kanker. Uji satistik yang digunakan ialah uji t tidak berpsangan. Hasil penelitian mendapatkan peningkatan kadar CA 15-3 kelompok uji ialah 8,3±3,5 U/mL sedangkan pada kelompok kontrol sebesar 11,4±3,4 U/mL. Tidak didapatkan perbedaan bermakna untuk kenaikan CA 15-3 pada kelompok uji dan kelompok kontrol (p=0,069). Simpulan penelitian ini ialah pemberian propolis pada pasien kanker payudara stadium lanjut secara deskriptif berefek dengan kadar peningkatan CA 15-3 yang lebih rendah dibandingkan kelompok kontrol tetapi secara statistik tidak terdapat perbedaan bermakna antara kedua kelompok penelitian. Kata kunci: propolis; kanker payudara; penanda CA 15-3
Liposarcoma of the Thyroid Gland: A Case Report Christian Manginstar; Marselus Merung; Denny Saleh; Leise Limpeleh; Enika Tilaar; Ridel Torar
Medical Scope Journal Vol. 6 No. 1 (2024): Medical Scope Journal
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/msj.v6i1.51654

Abstract

Abstract: Liposarcoma is one of the most common soft tissue tumors in adults. Liposarcoma is usually found in retroperitoneal organs and extremities, but rarely in the thyroid gland. We presented a case of dedifferentiated liposarcoma in the thyroid gland. A 56-year-old woman with a history of a lump in her neck for ten years. Malignancy was suspected due to the local extension of the tumor, therefore, complete resection of the tumor was performed. Histopathological examination showed a dedifferentiated liposarcoma. Two months post-surgery, the patient suffered from lung and brain metastases and was treated with lenvatinib. The complaints reduced and there was no significant side effect during therapy. The treatments for liposarcoma are surgery, radiotherapy, chemotherapy, and targeted therapy. Surgery followed by radiotherapy and chemotherapy is the option in the treatment of liposarcoma. This patient underwent surgery with the histopathological result of dedifferentiated thyroid liposarcoma. In the nine-month follow-up of therapy, there were no complaint of the patient. In this case, dedifferentiated liposarcoma in the thyroid gland with metastases was treated surgically followed by lenvatinib administration gave satisfactory result. Keyword: liposarcoma; thyroid gland; dedifferentiated liposarcoma; malignant tumor
Tiroidektomi Endoskopi Transoral dengan Pendekatan Vestibular Untuk Nodul Tiroid: Serial 12 Pasien Pertama di RSUP Prof. Dr. R. D. Kandou Riston R. Sitompul; Victor Pontoh; Marselus Merung; Christian Manginstar
Medical Scope Journal Vol. 6 No. 2 (2024): Medical Scope Journal
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/msj.v6i2.51515

Abstract

Abstract: Transoral endoscopic thyroidectomy by vestibular approach (TOETVA), showed a comparable result to the conventional thyroidectomy, without any scar as the advantage. This study aimed to present the feasibility and safety of patients with solitary or multinodular goitre and or papillary thyroid carcinoma using TOETVA. This was a case series using 12 patients recorded undergoing TOETVA procedure. Eleven patients’ specimen obtained through FNAB resulted as benign nodule. In one patient, the nodule was malignant and unilateral, therefore, endoscopic isthmolobectomy was performed. Outcomes and measures included conversion to open conventional surgery, operative time, intraoperative blood loss, size of the thyroid gland, postoperative hospital stay, visual analogue scores, and postoperative complications. The results showed a total of 12 patients; all were women, aged 33-64 years. The size of thyroid nodules ranged from 2 cm to 7 cm. One patient got converted to open isthmus lobectomy. In this series, none of the patients were noted to have mental nerve injury but two patients developed anterior neck chin skin bruise. The mean postoperative VAS measurements were 2, 1, and no pain or 0, on the first, second, third, and seventh postoperative days, respectively. In conclusion, endoscopic thyroidectomy is feasible, safe, and comparable to open thyroidectomy and yields excellent aesthetic results. Keywords: endoscopic thyroidectomy; minimally invasive surgical procedures; thyroid neoplasms    Abstrak: Tiroidektomi endoskopi transoral dengan pendekatan vestibular (TOETVA), menunjuk-kan hasil sebanding dengan tiroidektomi konvensional, tanpa adanya bekas luka sebagai keuntungan. Penelitian ini bertujuan untuk menyajikan kelayakan dan keamanan pasien dengan penyakit gondok soliter atau multinodular dan atau karsinoma tiroid papiler menggunakan TOETVA. Jenis penelitian ialah serial kasus yang menjalani TOETVA selama Januari 2018 hingga Desember 2019 di RSUP Prof. Dr. R. D. Kandou. Terdapat 12 pasien tercatat menjalani prosedur TOETVA; 11 spesimen pasien diambil melalui FNAB dan menghasilkan nodul jinak. Pada salah satu pasien didapatkan nodul ganas unilateral sehingga dilakukan istmolobektomi endoskopi. Hasil dan tindakan termasuk konversi ke operasi konvensional terbuka, waktu operasi, kehilangan darah intraoperatif, ukuran kelenjar tiroid, rawat inap pasca operasi, VAS, dan komplikasi pasca operasi. Hasil penelitian mendapatkan 12 pasien, semuanya berjenis kelamin perempuan, berusia 33-64 tahun. Ukuran nodul tiroid berkisar 2 - 7 cm. Satu pasien diubah menjadi lobektomi terbuka. Tidak ada pasien yang tercatat mengalami cedera saraf mental, namun dua pasien mengalami memar pada kulit dagu leher bagian depan. Rerata pengukuran VAS pasca operasi ialah 2, 1, dan tidak nyeri atau 0, masing-masing pada hari pertama, kedua, ketiga, dan ketujuh pasca operasi. Simpulan penelitian ini ialah tiroidektomi endoskopi layak dilakukan, aman dan sebanding dengan tiroidektomi terbuka serta memberikan hasil estetika yang sangat baik. Kata kunci: tiroidektomi endoskopi transoral; minimal invasif; neoplasma tiroid
Co-Authors Denny Saleh Enika Tilaar Ferry Kalitouw Filandy Pai Fredrik G. Langi Leise Limpeleh Marselus Merung Melfrits Siwabessy Ridel Torar Riston R. Sitompul Victor Pontoh