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E Mudjaddid, E
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Medicine & Pharmacology

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Relationship between Symptoms of Depression and Anxiety with Major Adverse Cardiac Event in 7 days in Patients with Acute Coronary Syndrome in Cipto Mangunkusumo Hospital Sari, Diah Pravita; Mudjaddid, E; Ginanjar, Eka; Muhadi, Muhadi
Jurnal Penyakit Dalam Indonesia Vol. 5, No. 4
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Introduction. One of the causes of death in acute coronary syndrome is the occurrence of complication known as major adverse cardiac events (MACE). There are several predictors of the occurance of MACE in patients with ACS, including depression and anxiety. Thi study aimed to determine the association between depression and anxiety with major adverse cardiac events within 7 days in patients with acute coronary syndrome. Methods. Study with prospective cohort design to examine the association between depression and anxiety with MACE within 7 days of ACS patients, using HADS questionnaires on ACS patients undergoing treatment at ICCU, Hospitalization RSCM in January - May 2018. Bivariate analysis was performed to calculate the risk ratio (RR) of MACE occurrence within 7 days in the depression and anxiety group using SPSS. Results. Obtained number of subjects who meet the inclusion criteria of 114 people. Depression was obtained in 7% of subjects, Anxiety was obtained in 28,95% of subjects, and MACE was obtained in 9.6% of subjects. In the Depression group, MACE 7 days occurred in 12.5% of subjects. In the Anxiety group, MACE 7 days occurred in 21,2% of subjects. In bivariate analysis, Anxiety increased the risk of MACE within 7 days in patients with ACS, with relative risk (RR) of 4,2 (IK 1,34 – 13,70). Conclusions. Anxiety in patients with ACS is an independent predictor of MACE within 7 days and increases the risk of a 7 day MACE. There was no correlation between depression and MACE within 7 days in patients with ACS.
Association between Disease Activity and Depression inRheumatoid Arthritis Patients Mudjaddid, E; Puspitasari, Myra; Setyohadi, Bambang
Jurnal Penyakit Dalam Indonesia Vol. 4, No. 4
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Introduction. Rheumatoid Arthritis (RA) is a chronic, systemic disease that cause synovialinflammation and progressive destruction to cartilages and deformities. Prevalence of depressionin RA patients is 20 to 30%. Disease activity is considered to have association with depression. This study aims to identify the prevalence of depression in RA patients and the associationbetween disease activity index and depression in RA patients. Methods. A cross-sectional study of 145 RA patients that fulfilled the inclusion criteria was conducted in Rheumatology Outpatient Clinic at Cipto Mangunkusumo Hospital Jakarta from January to March 2017.Evaluation of Disease Activity Score - 28 (DAS 28) and Back Depression Inventory (BDI) was done to the patients. Statistical analysis was performed using SPSS version 20. Categorical variables were compared using chi-square test. Results. A total of 145 subjects were included in this study and most of them were female (90.3%). Median age of subjects was 55 years (range 19-83 years). Forty five subject (31%) were identified having psychosocial stressor. The proportion of depression in RA patients was 35.9% (95% CI 30-42%). Based on Disease Severity Score, it was found that subject with mild, moderate, and severe score were 24 (82.8%), 52 (66.7%), and 4 (23.5%), respectively. There was significant association between disease activity with depressionin rheumatoid arthritis patient (p= 0.001).
Correlation between Spiritual Aspect and Serum Interleukin-6Level in Chronic Hemodialysis Patients Hanida, Wika; Mudjaddid, E; Nasution, Habibah Hanum; Shatri, Hamzah
Jurnal Penyakit Dalam Indonesia Vol. 3, No. 1
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Introduction. Holistic approach in psychosomatic focus on spirituality factor and spiritual support is expected to improve services and psychological condition of the patients. Inflammatory response during hemodialisis procedure hence increased with the evidence of increasing level of serum interleukin-6 (IL-6). Further research is still needed to see the spiritual factors that can decrease the inflammatory factors. Methods. Cross sectional study on 51 chronic hemodialisis patients at RSUP. H. Adam Malik and RSU dr. Pirngadi Medan between July-August 2014. Serum IL-6 was measured using quantitative enzyme-linked immune sorbent assay (ELISA) methods. Blood samples and spiritual aspect assessment by handing out FACIT Sp-12 questionnaire to patients were taken in the morning, 30 minutes before hemodialisis. Results. Subscale meaning 10.67 (SB 2.66), peace 9.63 (SB 2.19) and faith 11.47 (SB 2.91). Median serum IL-6 level is 5,63 (1,48- 28,88) pg/mL. Median FACIT Sp-12 is 30,00 (18-48). Correlation test between serum IL-6 level and spiritual aspect have shown statistically weak negative correlation (correlation coefficient -0,330, p=0.018). Conclusions: spirituality level in chronic hemodialisis patients are higher. Weak negative correlation between serum IL-6 level and spiritual level on chronic hemodialisis patients was found in this study.
Co-Authors -, Fachrull Anggilia Stephanie, Anggilia Ari Fahrial Syam Bambang Setyohadi Eka Ginanjar Esthika Dewiasty, Esthika Habibah Hanum Nasution, Habibah Hanum Hamzah Shatri Muhadi Muhadi, Muhadi Myra Puspitasari, Myra Ranty, Stefanus Satrio Sari, Diah Pravita Wika Hanida, Wika