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All Journal International Journal of Multidisciplinary Approach Research and Science
Muhammad Abbagoni Abubakar
University of Maiduguri
Agriculture, Biological Sciences & Forestry Chemical Engineering, Chemistry & Bioengineering Economics, Econometrics & Finance Immunology & microbiology Social Sciences

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Production and Utilization of Insulin from Stevia Leave (Rebaudiana Bertoni) for the Treatment of Diabetes Mellitus Muhammad Abbagoni Abubakar; Babagana Gutti; Abdulhalim Musa Abubakar; Amina Mohamed Ali; Muhammad Jamil Umar Sabo
International Journal of Multidisciplinary Approach Research and Science Том 1 № 02 (2023): International Journal of Multidisciplinary Approach Research and Science
Publisher : Pt. Riset Press International

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59653/ijmars.v1i02.63

Abstract

Stevia (Rebaudiana bertoni) leave, is an ancient perennial shrub mostly found in South America in countries like Paraguay and Brazil. It contains a low-calorie sweetener, which is about 300 times sweeter than sucrose. Diabetes mellitus is among the common metabolic disorders affecting about 2.8% of the world’s population and is reported to reach 5.4% by the year 2025. In this work, insulin was successfully extracted from Rebaudiana bertoni to serve as an alternative to bovine insulin extracted from animals which is devoid of the risk of transferring infectious diseases from the animals to the diabetic patient as is the case with convectional animal-based insulin. Gas Chromatography-Mass Spectroscopy (GC-MS) and Fourier Transform InfraRed (FTIR) analysis were used to analyze and determine the functional groups available in the isolated compound and the results shows that it has retention time of 14.11 min; abundance/peak area (% PA) of 86.613 %; mass number (m/z) of 413 g/mol; molecular peak ion of 149; fragmentation patterns of 7; and C20H29BrO4 as molecular formula and phthalic acid, 8-bromoctyl butyl ester as IUPAC name. The insulin was tested on three groups of rats (Rattus norvegicus) whereby the glucose level was monitored, and the result shows that the extracted insulin was found to be effective in addition to having antidiabetic effect.
Optimization of Insulin Yield from Extract of Stevia Leave (Rebaudiana Bertoni) Muhammad Abbagoni Abubakar; Abdulhalim Musa Abubakar; Musa Askira Abubakar; Dahiru Muhammad Dahiru
International Journal of Multidisciplinary Approach Research and Science Том 1 № 03 (2023): International Journal of Multidisciplinary Approach Research and Science
Publisher : Pt. Riset Press International

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59653/ijmars.v1i03.86

Abstract

Stevia (Rebaudiana bertoni) leave, is an ancient perennial shrub mostly found in South America such as Paraguay and Brazil, it contains a low-calorie sweetener, which is about 300 times sweeter than sucrose. Insulin is a polypeptide hormone, which has an anabolic property, insulin has a vital role in regulation of carbohydrate metabolism, it also enhances the metabolism of fat and proteins and regulation of certain gene expression. Design expert software 10.0 was used to design the experimental data for the optimization of insulin yield in stevia (Rebaudiana bertoni) leave. Custom design with 3 factor and one response was applied, the independent variables were amount of stevia powder (g), volume of n-hexane (ml) and volume of ethyl acetate (ml) and the response is percentage of insulin yield (%). In this research work, insulin was successfully extracted from stevia (Rebaudiana bertoni) leave and the optimum yield was determined. The optimum extraction conditions for optimum yield of insulin were found to be: 5.668 g of stevia powder, 49.107 ml of n-hexane and 32.386 ml of ethyl acetate.
Co-Authors Abdulhalim Musa Abubakar Amina Mohamed Ali Babagana Gutti Dahiru Muhammad Dahiru Muhammad Jamil Umar Sabo Musa Askira Abubakar