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All Journal Biological Environment and Pollution
Laili Mufli Zusrina
Universitas Gadjah Mada
Agriculture, Biological Sciences & Forestry Energy Environmental Science

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Histopathological evaluation of hepatic tissue of yellow Rasbora (Rasbora lateristriata) exposed to paracetamol Nur Indah Septriani; Ruth Liananda Citra Dolok Saribu; Tia Apriliyani; Ina Karlina; Nur Ainun Oktavia Pusparini; Laili Mufli Zusrina; Ria Vinola Septhya Sari; Hayu Swari Allimi; Murtiadi Erlan Supraitno; Faisal Saeed; Eben Ezer Simanungkalit; Pradnya Paramita; Bambang Retnoaji; Fajar Sofyantoro; Nastiti Wijayanti
Biological Environment and Pollution Vol. 3 No. 1 (2023)
Publisher : Association for Scientific Computing, Electronics, and Engineering (ASCEE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31763/bioenvipo.v3i1.595

Abstract

Excessive consumption of paracetamol may lead to hepatic necrosis, nephrotoxicity, extra-hepatic lesions, and even fatality in both humans and animals. The objective of this study was to examine the histological changes in the hepatocytes of yellow rasbora (Rasbora lateristriata) exposed to paracetamol. The fish were subjected to varying concentrations of paracetamol over a period of four days. Group I served as the control group without any paracetamol exposure. Groups II, III, and IV were exposed to 2, 3, and 4 mg/L of paracetamol, respectively. A total of six individuals were allocated to each of the four experimental groups. The histological analysis of the hepatic tissue following paracetamol exposure at concentrations of 2, 3, and 4 mg/L revealed hepatic damage characterized by picnosis, necrosis, and vacuolization. In summary, higher concentrations of paracetamol were associated with an increase in the severity of histopathological changes in the hepatic tissues of yellow rasbora.
Co-Authors Bambang Retnoaji Eben Ezer Simanungkalit Faisal Saeed Fajar Sofyantoro Hayu Swari Allimi Ina Karlina Murtiadi Erlan Supraitno Nastiti Wijayanti Nur Ainun Oktavia Pusparini Nur Indah Septriani Pradnya Paramita Ria Vinola Septhya Sari Ruth Liananda Citra Dolok Saribu Tia Apriliyani