Biological Environment and Pollution
Vol. 3 No. 1 (2023)

Histopathological evaluation of hepatic tissue of yellow Rasbora (Rasbora lateristriata) exposed to paracetamol

Nur Indah Septriani (Universitas Gadjah Mada)
Ruth Liananda Citra Dolok Saribu (Universitas Gadjah Mada)
Tia Apriliyani (Universitas Gadjah Mada)
Ina Karlina (Universitas Gadjah Mada)
Nur Ainun Oktavia Pusparini (Universitas Gadjah Mada)
Laili Mufli Zusrina (Universitas Gadjah Mada)
Ria Vinola Septhya Sari (Universitas Gadjah Mada)
Hayu Swari Allimi (Universitas Gadjah Mada)
Murtiadi Erlan Supraitno (Universitas Gadjah Mada)
Faisal Saeed (Universitas Gadjah Mada)
Eben Ezer Simanungkalit (Universitas Gadjah Mada)
Pradnya Paramita (Universitas Gadjah Mada)
Bambang Retnoaji (Universitas Gadjah Mada)
Fajar Sofyantoro (Universitas Gadjah Mada)
Nastiti Wijayanti (Universitas Gadjah Mada)



Article Info

Publish Date
30 Jun 2023

Abstract

Excessive consumption of paracetamol may lead to hepatic necrosis, nephrotoxicity, extra-hepatic lesions, and even fatality in both humans and animals. The objective of this study was to examine the histological changes in the hepatocytes of yellow rasbora (Rasbora lateristriata) exposed to paracetamol. The fish were subjected to varying concentrations of paracetamol over a period of four days. Group I served as the control group without any paracetamol exposure. Groups II, III, and IV were exposed to 2, 3, and 4 mg/L of paracetamol, respectively. A total of six individuals were allocated to each of the four experimental groups. The histological analysis of the hepatic tissue following paracetamol exposure at concentrations of 2, 3, and 4 mg/L revealed hepatic damage characterized by picnosis, necrosis, and vacuolization. In summary, higher concentrations of paracetamol were associated with an increase in the severity of histopathological changes in the hepatic tissues of yellow rasbora.

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Journal Info

Abbrev

bioenvipo

Publisher

Subject

Agriculture, Biological Sciences & Forestry Energy Environmental Science

Description

We invite authors to submit articles in the fields It publishes original scientific work related to a diverse range of fields in the environment, pollution, and toxicology. The journal invites research articles and reviews concerning environmental pollution, in the following subjects: Damage to the ...