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All Journal Jurnal Farmasi dan Sains Indonesia (JFSI) Sains Medisina
Yusuf Anggoro Mukti
Universitas Sari Mulia
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience

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Studi Bioekivalensi Obat Paracetamol Generik Dan Non Generik Secara In Vitro Siti Mutaharah; Saftia Aryzki; Rina Saputri; Yusuf Anggoro Mukti
Sains Medisina Vol 1 No 6 (2023): Sains Medisina
Publisher : CV. Wadah Publikasi Cendekia

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Abstract

Drugs are one component of health that is irreplaceable in order to improve public health status. There are 2 types of drugs circulating in the market, namely generic and non-generic. Paracetamol is classified as a class 1 biopharamcetic drug which is formulated as a product with high solubility in water and has high intestinal permeability, almost 100% absorption can be expected at least as much as 85% of the soluble product in in vitro testing. In vitro testing was carried out for 180 minutes with a span of 15 minutes using generic paracetamol and patented paracetamol to determine whether there is a difference in the quality of the drugs and to make comparisons with the aim of knowing their bioequivalence.
Uji Aktivitas Analgetika Ekstrak Daun Mahang (Macaranga bancana) Terhadap Mencit Putih (Mus musculus L.) Jantan Yusuf Anggoro Mukti; Nadia Oktavia; Ine Andrian
Jurnal Farmasi & Sains Indonesia Vol 7 No 1 (2024)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol7no1p45-50

Abstract

According to The International Association for the Study of Pain (IASP) pain is an unpleasant sensory and emotional experience due to damage or threat of tissue damage. When there is damage to body tissue, such as surgery, it will produce damaged cells with the consequence of releasing algesic chemicals that can cause pain. Most clinical guidelines recommend NSAIDs as first-line treatment for pain. The use of NSAID drugs has several side effects including increasing the risk of impaired renal function, bleeding in the gastrointestinal tract, myocardial infarction and stroke. Various side effects caused by using NSAID drugs, then treatment using herbal medicine to treat pain is still an alternative treatment that is expected to have smaller side effects. One plant that is very useful as a medicine is the mahang plant. Based on the results of research, the methanol extract of mahang leaves contains alkaloid, flavonoid, polyphenol and terpenoid/steroid compounds. Flavonoids are secondary metabolite compounds contained in mahang leaf extract which are thought to have pharmacological effects as analgesic agents. The purpose of this study was to evaluate the presence or absence of analgesic activity of mahang leaf extract. This research method is the Tail Flick Test Method using heat as a pain inducer. The administration of mahang leaf extract (Macaranga bancana) to male white mice (Mus musculus L.) can reduce pain due to hot water stimulation as indicated by the extension of the tail flick response time. The optimum concentration of mahang leaf extract that gives analgesic effect is the concentration of mahang leaf extract 400mg/KgBB.
Co-Authors Ine Andrian Nadia Oktavia Rina Saputri Saftia Aryzki Siti Mutaharah