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Rina Saputri
Program Studi Sarjana Farmasi, Universitas Sari Mulia
Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Potensi Antimikroba Ekstrak Etanol Kulit Luar Buah Cempedak (Artocarpus integer (Thunb.) Merr.) Rina Saputri; Ali Rakhman Hakim; Dahlia Syahrina; Fatthiya Lisyanti
Jurnal Surya Medika (JSM) Vol 5 No 1 (2019): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (440.188 KB) | DOI: 10.33084/jsm.v5i1.945

Abstract

The background of this research is to develop the potential of biological resources in South Kalimantan. In particular, the biological source is cempedak fruit. The use of cempedak which has been scientifically studied is the use of cempedak bark as anti-malaria. Other studies related to other parts of cempedak are still not widely used. Based on the potential possessed by cempedak bark, it is likely that other parts of cempedak also have potential as traditional medicine. This study aims to identify the content of secondary metabolites from the outer skin of cempedak fruit, analyze the potential of the outer skin of cempedak fruit as an antimicrobial and analyze the effective dose as an antimicrobial. The method used to see MIC values with liquid dilution and KBM values with solid dilution. The results of phytochemical identification showed that the ethanol extract of the outer skin of cempedak fruit contained secondary metabolites in the form of saponins, tannins, flavonoids and alkaloids which have antimicrobial potential. The results of the antimicrobial activity test showed the MIC value of the ethanol extract of cempedak fruit outer skin against Escherichia coli bacteria at a concentration of 50% and against Staphylococcus aureus at a concentration of 25%. The KBM value also shows the same value as KHM. Based on the results of the study it can be concluded that the ethanol extract of cempedak fruit outer skin has broad-spectrum antimicrobial activity.
Narrative Review: Optimasi Etanol sebagai Pelarut Senyawa Flavonoid dan Fenolik Ali Rakhman Hakim; Rina Saputri
Jurnal Surya Medika (JSM) Vol 6 No 1 (2020): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v6i1.1641

Abstract

The use of ethanol as a solvent for secondary metabolite compounds is very widespread. Ethanol can dissolve flavonoid compounds and phenolic compounds from plants. To be able to utilize ethanol as a solvent is dependent on some factors of concentration, temperature, time, and selection of extraction methods. This study uses the method by searching scientific articles from the MDPI website database. The Ultrasound-Assisted Extraction (UAE) method is very suitable for the optimization of ethanol as a solvent. The optimal use of ethanol is in the concentration range of 50-80%, temperature conditions in the range of 40-70ºC, and the extraction time is in the range of 30 minutes - 24 hours.
Narrative Review: Implementasi Distribusi Obat yang Baik di Pedagang Besar Farmasi Mustaqimah Mustaqimah; Rina Saputri; Ali Rakhman Hakim
Jurnal Surya Medika (JSM) Vol 6 No 2 (2021): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v6i2.2128

Abstract

Distribution of pharmaceutical products from the pharmaceutical industry before reaching the pharmacy service point must be through wholesale. Good distribution practice methods are a set of standardized routine working methods, which ensure the quality, safety, and efficacy of pharmaceutical products remain intact from the very beginning to the end of the expiration period. Good distribution practice methods must be implemented by all wholesale in Indonesia so that wholesale operations can run effectively and efficiently. All pharmaceutical wholesalers must have standard operating procedures, personnel with integrity, and a good documentation system.
Analisis Faktor yang Berhubungan dengan Kepatuhan Pasien di Kabupaten Banjar Mustaqimah Mustaqimah; Rina Saputri; Ali Rakhman Hakim; Reny Indriyani
Jurnal Surya Medika (JSM) Vol 7 No 1 (2021): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v7i1.2659

Abstract

Hypertension is still the most common disease in the world. South Kalimantan Province in 2018 became the province with the highest number of hypertension sufferers in Indonesia. Hypertensive patients will undergo hypertension therapy for the rest of their lives so that blood pressure can still be well controlled. Lifelong therapy can reduce patient compliance in taking hypertension drugs; this can result in failed therapeutic goals and lead to the emergence of other diseases such as myocardial infarction and others. The purpose of this study was to analyze sociodemographic factors and clinical factors that may be related to patient compliance in taking hypertension drugs in Banjar Regency. The results showed that the majority of respondents had low compliance in consuming hypertension drugs. The analysis showed that sociodemographic factors such as gender, age, occupation, and place of getting the drug and clinical factors in the form of drugs used and blood pressure control did not show a significant relationship. The education factor shows a p-value < 0.05, which indicates the education factor has a significant relationship.
Analisis Toksisitas Akut Kombinasi Captopril dengan Rebusan Daun Sirsak pada Tikus Galur Wistar Rina Saputri; Mustaqimah Mustaqimah; Ali Rakhman Hakim
Jurnal Surya Medika (JSM) Vol 7 No 2 (2022): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v7i2.2849

Abstract

Hypertension is a degenerative disease that requires lifelong therapy. Along with the development of time, nowadays people are more interested in consuming traditional medicine, especially by using plants. In addition to consuming soursop leaf decoction, people also continue to use conventional medicine to help control hypertension. The combination of conventional medicine and traditional medicine can cause unwanted reactions if not used in the right dosage, one of which is the risk of acute toxicity. Until now there is no published data showing the acute toxicity analysis of the combination of captopril with soursop leaf decoction. The purpose of the study was to determine the maximum dose of the combination of captopril and soursop leaf decoction that could be used. The method used in this study is an advanced experimental study with a random block design using 30 test animals divided into 10 groups. The results of the acute toxicity test conducted did not show any death of the test animals within 24 hours and up to 7 days of observation in all experimental groups. The results of the physical observation test for 7 days showed that all rats were in normal condition in all experimental groups. The conclusion of this study is that the combination of captopril up to a dose of 150 mg/day (dose in humans before conversion to test animals) + soursop leaf decoction with an effective dose of 300 ml (dose in humans before conversion to test animals) did not show any death and symptoms toxicity in test animals.
Aktivitas Antioksidan Kulit Buah Cempedak (Artocarpus integer (Thunb.) Merr.) asal Kalimantan Selatan Ali Rakhman Hakim; Rina Saputri; Amanda Shelvia Savitri; Anisa Ujuldah; Fitri Sadlia
Jurnal Surya Medika (JSM) Vol 7 No 2 (2022): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v7i2.2858

Abstract

The increasing incidence of diseases related to oxidative stress among the human population has led to an increase in the consumption of natural antioxidants in the human diet. The purpose of this study was to determine the antioxidant activity of cempedak fruit skin extract with 50% ethanol and 70% ethanol as solvents. The method used was testing of radical inhibitory activity with the DPPH method (1,1-diphenyl-picrylhydrazil) and as a positive control was vitamin C. The results of phytochemical screening were known to contain phenolics, flavonoids, and tannins. The results of the antioxidant activity of E50% obtained IC50 values of 650.07 ppm and IC50 of E70 of 1219.69 ppm. From these results, it can be concluded that the skin of the cempedak fruit does not have antioxidant activity.
Identifikasi Senyawa Kimia Ekstrak Etanol Mentimun (Cucumis sativus L.) dan Ekstrak Etanol Nanas (Ananas comosus (L) Merr.) Ali Rakhman Hakim; Rina Saputri
Jurnal Pharmascience Vol 4, No 1 (2017): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v4i1.5753

Abstract

ABSTRAK Bahan alam digunakan manusia sebagai obat untuk menyembuhkan, mencegah penyakit tertentu dan menjaga kondisi badan agar tetap sehat. Bahan alam yang digunakan dikenal dengan istilah obat herbal. Mentimun (Cucumis sativus L) dan Nanas (Ananas cosmosus (L) Merr) merupakan sebagian dari bahan alam yang dapat digunakan sebagai alternatif pengobatan. Penelitian ini bertujuan untuk mengidentifikasi kandungan senyawa kimia pada ekstrak etanol mentimun dan ekstrak etanol nanas yaitu senyawa saponin, steroid, terpenoid, tanin dan secara kualitatif. Ekstrak etanol mentimun dan ekstrak etanol nanas didapatkan dengan metode maserasi. Hasil identifikasi senyawa kimia menunjukan ekstrak etanol mentimun mengandung senyawa kimia terpenoid, saponin dan fenolik. Ekstrak etanol nanas mengandung terpenoid dan fenolik. Kata kunci: Identifikasi senyawa kimia, Mentimun (Cucumis sativus L), Nanas (Ananas cosmosus (L) Merr) ABSTRACT Natural materials has used by humans as a medicine to cure, prevent certain diseases and maintain body condition in order to stay healthy. Natural materials are used is known as herbal medicine. Cucumber (Cucumis sativus L) and Pineapple (Ananas cosmosus (L) Merr) is part of the natural materials that can be used as an alternative treatment. This study aims to identified the chemical compounds in extracts of cucumber ethanol and ethanol extract of pineapple there are saponins, steroids, terpenoids, tannins and qualitatively. The ethanol extract of cucumber and pineapple ethanol extracts obtained by maceration method. The results of the identification of chemical compounds showed the ethanol extract of cucumber contains chemical compounds terpenoids, saponins and phenolic. The ethanol extract of pineapple contains terpenoids and phenolic. Keywords: Identification of chemical compounds, cucumber (Cucumis sativus L), pineapple (Ananas comosus (L) Merr)
Analisis Toksisitas Akut Ekstrak Etanol Kulit Buah Cempedak pada Tikus Galur Wistar Ali Rakhman Hakim; Rina Saputri
Jurnal Pharmascience Vol 5, No 2 (2018): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v5i2.5799

Abstract

Kulit buah Cempedak yang digoreng (Manday) merupakan salah satu makanan yang umum dikonsumsi masyarakat di Kalimantan Selatan. Berdasarkan pengalaman dari beberapa masyarakat, keluhan yang sering terjadi adalah perut terasa perih dan kepala pusing. Evaluasi sifat toksik dari bagian tumbuhan yang dikonsumsi oleh masyarakat sangat penting untuk dilakukan dengan mempertimbangkan perlindungan kesehatan masyarakat karena paparan senyawa kimia dari bagian tumbuhan yang dapat menyebabkan efek yang tidak diinginkan pada masyarakat. Penelitian ini bertujuan untuk mengidentifikasi senyawa kimia dan efek toksisitas akut dari ekstrak etanol kulit buah cempedak. Kulit buah cempedak dikeringkan dengan menggunakan oven. Ekstraksi kulit buah cempedak menggunakan cara maserasi dengan cairan penyari etanol. Tikus uji diberi larutan kontrol Na CMC dan ekstrak dengan dosis 300 mg/kgBB, 1000 mg/kgBB, 2000 mg/kgBB, dan 5000 mg/kgBB. Hasil identifikasi senyawa kimia didapatkan positif mengandung triterpenoid, flavonoid, tanin, dan senyawa fenolik. Tikus uji yang menerima ekstrak dengan dosis 1000 mg/kgBB, 2000 mg/kgBB, dan 5000 mg/kgBB terjadi perubahan pada tikus uji berdasarkan pengamatan fisik yaitu mengalami peningkatan detak jantung atau takikardi, pernapasan cepat, tremor, dan agresif. Kata kunci: Kulit buah cempedak, senyawa kimia, toksisitas akut Rind of Cempedak fruit (Manday) is one of the foods commonly consumed by people in South Kalimantan. Based on the experience of several communities, complaints that often occur are sore stomach and headache. Evaluation of the toxic properties of plant parts consumed by the community is very important to be done by considering public health protection due to exposure to chemical compounds from parts of plants that can cause undesirable effects on the community. This study aims to identify chemical compounds and acute toxicity effects of ethanol extract rind of cempedak fruit. Rind of Cempedak fruit has dried using an oven. Extraction of cempedak fruit skin using maceration method with ethanol. Test rats were given Na CMC as a control and extract with dose 300 mg / kgBB, 1000 mg / kgBB, 2000 mg / kgBB, and 5000 mg / kgBB. The results of the identification of chemical compounds were obtained positively containing triterpenoids, flavonoids, tannins, and phenolic compounds. The test rats that received extracts at a dose of 1000 mg / kgBW, 2000 mg / kgBB, and 5000 mg / kgBW were changed in the test rats based on physical observations that experienced an increase in heart rate or tachycardia, rapid breathing, tremor, and aggressive. Keywords: acute toxicity, chemistry compounds, rind of cempedak fruit
LITERATURE REVIEW: HUBUNGAN KEPATUHAN KEMOTERAPI DENGAN KUALITAS HIDUP PASIEN KANKER PAYUDARA Arya Andika Saputra; Rifa'atul Mahmudah; Rina Saputri
Journal of Nursing Invention Vol 2 No 1 (2021): Journal of Nursing Invention
Publisher : LPPM Universitas Sari Mulia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (310.578 KB)

Abstract

Latar Belakang: Kanker disebabkan oleh pertumbuhan sel-sel jaringan yang abnormal. Kanker payudara merupakan permasalahan utama kesehatan pada kalangan wanita. Salah satu penatalaksanaan utama pada penyakit kanker yaitu kemoterapi. Proses kemoterapi harus memiliki tingkat kepatuhan tinggi agar dapat menunjang keberhasilan terapi. Keberhasilan terapi akan meningkatkan kualitas hidup pasien. Tujuan: penelitian ini untuk mengetahui tentang hubungan kepatuhan kemoterapi dengan kualitas hidup pasien kanker payudara. Metode: Penelitian ini menggunakan literature review, dalam pencarian literature bersumber dari tiga database (Pubmed, Doaj, Google Scholer), menggunakan kata kunci sesuai dengan tema. Hasil: Kepatuhan pasien kanker payudara yang menjalani kemoterapi dipengaruhi oleh tingkat stadium dan efek samping sistemik dari pengobatan. Kualitas hidup pasien kanker payudara dipengaruhi oleh banyak faktor. Kualitas hidup pasien kanker payudara dapat ditingkatkan dengan pemberian edukasi. Pasien kanker payudara yang patuh menjalani kemoterapi memiliki kualitas hidup yang baik. Kesimpulan: adanya hubungan kepatuhan menjalani kemoterapi dengan kualitas hidup pasien kanker payudara. Rekomendasi: Diterapkannya sikap kepatuhan pada pasien kanker payudara dalam menjalani kemoterapi supaya dapat meningkatkan kualitas hidup pasien. Background: Cancer is caused by the growth of abnormal tissue cells. Breast cancer is a major health problem among women. For cancer sufferers must undergo chemotherapy. In the chemotherapy process, you must have a high level of adherence in order to improve your quality of life. Aim: This study was to determine the relationship between chemotherapy adherence and quality of life in breast cancer patients. Methods: this study used a literature review, in which literature searches were sourced from three databases (Pubmed, Doaj, Google Scholer), using keywords according to the theme. Results: Surveillance of breast cancer patients undergoing chemotherapy that was constructed by the stage level and systemic side effects of treatment. The quality of life of breast cancer patients by many factors. The quality of life for breast cancer patients can be improved by providing education. Breast cancer patients who are adherent undergo chemotherapy with good quality of life. Conclusion: There is a relationship who underwent chemotherapy with the quality of life of breast cancer patients. Recommendation: the application of attitudes to breast cancer patients in chemotherapy life can improve the quality of patients.
Efektivitas Terapi Antihipertensi Pada Kasus Krisis Hipertensi di Instalasi Gawat Darurat RSUD Ulin Banjarmasin Evita Peron Yoewono; Rina Saputri; Rifa’atul Mahmudah
Jurnal Pelayanan Kefarmasian dan Sains Vol 1 No 1 (2020): Journal Of Pharmaceutical Care and Science
Publisher : LPPM Universitas Sari Mulia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (319.502 KB)

Abstract

ABSTRACT Background: Hypertension crisis is a case of disease that often occurs, if not handled properly will cause comlication and death. This study was conducted to determine effective therapies in dealing with hypertensive crises so as to minimize the occurrence of complication and death in patients experiencing hypertensive crises Method: The research method is a prospective cohort. Data analysis using Pair T-Test and ANOVA, analytic analysis with evidence based medecine principles. Consists of 11 urgent hypertension samples and 9 emergency hypertension samples. Results: The results of the study for the case of hypertension urgency there are 6 therapeutic groups including furosemide, nicardipine, amlodipine, candesartan + amlodipine, clonidine and furosemide + nicardipine, but the therapy used is not in accordance with the guidelines but there are 2 groups of therapies that can reduce blood pressure including furosemide + nicardipine and clonidine, while for the case of emergence hypertension, there are 5 groups of therapies including nicardipine, amlodipine + nicardipine, furosemide, furosemide + candesartan + amlodipine and furosemide + candesartan + amlodipine + clonidine, the result is that nicardipine is a therapy that is in accordance with the guideline and the therapy is in accordance with the guideline and is in accordance with the guideline therapeutic target in lowering blood pressure. Conclusion: The use therapy is not in accordance with the guidelines for patients with hypertensive urgency cases, but is able to lower the patient’s blood pressure, whereas for patients with hypertensive emergencies the effective therapy is nicardipine. Keywords: Blood Pressure, Effectiveness, Hypertensive Crisis, Urgency Hypertension, Emergency Hypertension.
Co-Authors Agenia Rahman Agenia Rahman Ahmad Hidayat Aima Pitriya Ali Rakhman Hakim Alifira Adhany Yustian Alifira Adhany Yustian Amanda Shelvia Savitri Amanda Shelvia Savitri Amanda Shelvia Savitri Amanda Shelvia Savitri Anisa Ujuldah Anisa Ujuldah Annisa Fitria Annisa Fitria Ario Yudo Hariyanto Ario Yudo Hariyanto Arya Andika Saputra Arya Andika Saputra Aulia Damayanti Aulia Damayanti Aulia Rahma Az Zahra Aulia Rahmah Aulia Rahmah Budianor Budianor Dahlia Syahrina Eka Febrianti Maulani Ellora Griselda Gumarus Evita Peron Yoewono Fadhiyah Noor Anisa Fakhria Rizqina Fatthiya Lisyanti Fitri Sadlia Fitri Sadlia Fitri Yuliana, Fitri Ghina Raudhatul Jannah Gina Aulia Istiqomah Laurensia Yunita Lisda Handayani Muhammad Riduansyah Mustaqimah Mustaqimah Nor Habibah Nurul Amanah Nurul Hidayah Olvi Defitamira Putri Vidiasari Darsono Rani Normaya Sari Reny Indriyani Rifa'atul Mahmudah Rifa'atul Mahmudah Rifa’atul Mahmudah Rifa’atul Mahmudah Risky Amelia Risma Ananda Vania Rohama Rohama Saftia Aryzki Shafira Nor Holilah Sismeri Dona Siti Malahayati Siti Mutaharah Sri Rupaida Subhannur Rahman Taufik Kurahman Tri Anita Maharani Tuti Alawiyah Yayuk Puji Lestari Yusuf Anggoro Mukti Zhafirah Ressa Azzahra