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Jahanzaib Ali
Department of Biotechnology, Faculty of Life Sciences, University of Okara, Renala Khurd
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Education

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Novel CRISPR-Cas9 approach to combat with COVID-19 Jahanzaib Ali
BIOEDUSCIENCE Vol 7 No 2 (2023): BIOEDUSCIENCE
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/jbes/12275

Abstract

Background: The recent outbreak of Corona Virus has affected people all over the world so that WHO declared it a pandemic. This pandemic has become a major problem for people, health professionals, and research institutes that how to combat SARS-CoV-2. The objective of this review article is to provide a brief study that CRISPR/Cas9 can be used to combat SARS-CoV-2. Methods: The comparison of three genome editing techniques (ZNF, TALEN, and CRISPR/Cas9) is done. The mechanism of action of CRISPR/Cas9 is discussed. Results: The studies provided in this review article suggest that it is difficult to recognize this virus as they have their own metabolic machinery and they replicate their selves in the host cell and consume host cellular products to perform their own functions. The COVID-19 proteins may contain some specific areas that are suitable targets for therapy, such as tiny inhibitor molecules for viral polymerase, or impede the attachment of viruses to the receptor sites, for example, viral coat proteins can be used for vaccination purposes. Conclusion: CRISPR-Cas9 can be used to control the SARS-CoV-2 genome from replication and spread to other parts of the body as it can edit the genome quite efficiently. This proposed model will help in targeting the SARS-CoV-2 genome more precisely in the future.
Novel CRISPR-Cas9 approach to combat with COVID-19 Jahanzaib Ali
BIOEDUSCIENCE Vol 7 No 2 (2023): BIOEDUSCIENCE
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/jbes/12275

Abstract

Background: The recent outbreak of Corona Virus has affected people all over the world so that WHO declared it a pandemic. This pandemic has become a major problem for people, health professionals, and research institutes that how to combat SARS-CoV-2. The objective of this review article is to provide a brief study that CRISPR/Cas9 can be used to combat SARS-CoV-2. Methods: The comparison of three genome editing techniques (ZNF, TALEN, and CRISPR/Cas9) is done. The mechanism of action of CRISPR/Cas9 is discussed. Results: The studies provided in this review article suggest that it is difficult to recognize this virus as they have their own metabolic machinery and they replicate their selves in the host cell and consume host cellular products to perform their own functions. The COVID-19 proteins may contain some specific areas that are suitable targets for therapy, such as tiny inhibitor molecules for viral polymerase, or impede the attachment of viruses to the receptor sites, for example, viral coat proteins can be used for vaccination purposes. Conclusion: CRISPR-Cas9 can be used to control the SARS-CoV-2 genome from replication and spread to other parts of the body as it can edit the genome quite efficiently. This proposed model will help in targeting the SARS-CoV-2 genome more precisely in the future.
The Emergence and Impact of Artificial Intelligence in Biotechnology Jahanzaib Ali
BIOEDUSCIENCE Vol 8 No 1 (2024): BIOEDUSCIENCE
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/jbes/12578

Abstract

Introduction: Artificial intelligence (AI) has transformed many fields, including biotechnology. In recent years, artificial intelligence (AI) has played a critical role in altering research, drug development, genetic analysis, customized treatment, and other fields. The purpose of this review article is to investigate the numerous uses of AI in biotechnology, focusing on its impact on accelerating scientific advancement, improving data analysis, and driving innovation in the field. Method: Various AI approaches and methodologies used in biotechnology will be explored, including machine learning, deep learning, natural language processing, and picture identification. Results: This essay will also address important problems, future potential and ethical concerns regarding the use of AI in biotechnology. Conclusion: The integration of AI in biotechnology has redefined research paradigms, data analysis, and decision-making processes.
CRISPR-Cas9 System In Vivo Delivery to Combat HBV Jahanzaib Ali; Husnain Aslam; Abida Yousuf
BIOEDUSCIENCE Vol 7 No 3 (2023): BIOEDUSCIENCE
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/jbes/12693

Abstract

Background: Hepatitis B Virus (HBV) infection remains a major global health issue despite the availability of HBV vaccine. The novel CRISPR-Cas9 gene editing technology efficiently helps to cure HBV by disruption or cleavage of HBV DNA. Aims: Several in vitro and in vivo studies have demonstrated the effectiveness of HBV-specific clustered regularly interspaced short palindromic repeat (CRISPR)/associated protein 9 (CRISPR/Cas9) systems in cleaving HBV DNA. Methods: In vivo, delivery of the CRISPR/Cas9 system at target sites remains a major challenge that needs to be resolved before its clinical application in gene therapy for HBV. Results: In this review article, we comprehensively evaluate the progress, challenges, and therapeutic potential of CRISPR-Cas9 gene therapy for HBV using adeno-associated virus (AAV) vectors as delivery vehicles. Conclusion: The CRISPR-CAS9, HBV, AAV, delivery methods of CRISPR-CAS9 component in vivo, challenges, and future perspectives in harnessing this innovative technology to combat HBV infection.
Co-Authors Abida Yousuf Husnain Aslam