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Abida Yousuf
Department of Biotechnology, Faculty of Life Sciences, University of Okara, Renala Khurd, Pakistan
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Education

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CRISPR-Cas9 System In Vivo Delivery to Combat HBV Jahanzaib Ali; Husnain Aslam; Abida Yousuf
BIOEDUSCIENCE Vol 7 No 3 (2023): BIOEDUSCIENCE
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/jbes/12693

Abstract

Background: Hepatitis B Virus (HBV) infection remains a major global health issue despite the availability of HBV vaccine. The novel CRISPR-Cas9 gene editing technology efficiently helps to cure HBV by disruption or cleavage of HBV DNA. Aims: Several in vitro and in vivo studies have demonstrated the effectiveness of HBV-specific clustered regularly interspaced short palindromic repeat (CRISPR)/associated protein 9 (CRISPR/Cas9) systems in cleaving HBV DNA. Methods: In vivo, delivery of the CRISPR/Cas9 system at target sites remains a major challenge that needs to be resolved before its clinical application in gene therapy for HBV. Results: In this review article, we comprehensively evaluate the progress, challenges, and therapeutic potential of CRISPR-Cas9 gene therapy for HBV using adeno-associated virus (AAV) vectors as delivery vehicles. Conclusion: The CRISPR-CAS9, HBV, AAV, delivery methods of CRISPR-CAS9 component in vivo, challenges, and future perspectives in harnessing this innovative technology to combat HBV infection.
Co-Authors Husnain Aslam Jahanzaib Ali