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All Journal Majalah Kedokteran Andalas
Katrin Monika
Universitas Andalas
Health Professions Medicine & Pharmacology Public Health

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Pengaruh pemberian Iodine-131 terhadap viabilitas cell line Triple Negative Breast Cancer (TNBC) Katrin Monika; Aisyah Elliyanti; Yulia Kurniawati
Majalah Kedokteran Andalas Vol 46, No 6 (2023): Online Oktober
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i6.p912-918.2023

Abstract

AbstractObjective: To determine the effect of Iodine-131 administration on the viability of triple negative breast cancer cell lines and the IC50 value of Iodine-131. Methods: This study was a true experimental study using the MTT assay method to measure cell line viability after being given Iodine-131 at a dose of 7.8; 15.6; 31.3; 62.5; 125; 250; and 500 µCi for 24 hours. The research sample was the MDA-MB231 cell line which represents the Triple Negative Breast Cancer (TNBC) subtype of breast cancer. The IC50 value of Iodine-131 cell line MDA-MB231 was calculated using the GraphPad Prism-9 software. The results were analyzed using the Kruskal-Wallis and Post-Hoc Kruskal-Wallis tests, if p <0.05 was considered to significantly affect cell viability. Results: Iodine-131 affected cell viability in the MDA-MB231 cell line with a p<0.05. The IC50 value of Iodine-131 on the MDA-MB231 cell line was 255.7 µCi. Conclusion: Administration of Iodine-131 at a dose of 500 µCi for 24 hours significantly reduced the viability of the MDA-MB231 cell line. Iodine-131 dose of 255.7 µCi can inhibit 50% viability of the MDA-MB231 cell line.Keywords: Iodine-131; cell viability; cell line MDA-MB231; TNBC; IC50
Co-Authors Aisyah Elliyanti Yulia Kurniawati