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Suratno, Febiyanti
Universitas Islam Negeri Maulana Malik Ibrahim Malang
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology Public Health

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Catechins Green Tea Clones GMB4 Inhibit Inflammation Process of Atherosclerosis Through Decreasing TNF-Α Levels Susanti, Erna; Suratno, Febiyanti
Journal of Islamic Pharmacy Vol 1, No 1 (2016): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v1i1.3458

Abstract

Catechins Green tea clones GMB4 are potential natural subtances to inhibit  inflammation process in atherosclerosis. The purpose of this research to determine activity of  Catechins Green tea clones GMB4 to decrease TNF-α levels, as well as to determine optimal dose of Catechins. This research was conducted at the Laboratory of Physiology of the University of Brawijaya. The method used in this research is completely randomized design with five treatments: (1) Mice with standard feed (2) mice with high-fat diet (3) mice with high-fat diet + catechins 3mg / day (4) mice with a diet high fat + catechin 6mg / day (5) mice with high-fat diet + catechin 24mg / day. The treatment was done for 60 days and measured levels of TNF-α at the end of the research. The results showed that Catechins green tea clones GMB4 can inhibit the inflammatory process in atherosclerosis through decreasing levels of TNF-α at doses of 3mg / day. The conclusion of this research is catechins at a dose of 3 mg / day can inhibit inflammation in atherosclerosis significantly. Keywords : GMB 4 green tea clones, Catechins, inflammation, TNF-α
Co-Authors Erna Susanti