Sing Way
Faculty of Public Health, Duke University, Durham, US

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The Role of Chronic Inflammation in Stunting: A Systematic Literature Review Daniella Thomas; Sing Way
Scientific Journal of Pediatrics Vol. 1 No. 2 (2023): Scientific Journal of Pediatrics
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjped.v1i2.68

Abstract

Chronic inflammation can overactivate the body's immune system, causing excessive release of cytokines and inflammatory substances. This can affect the balance between the inflammatory response and the immune response, so that the immune system may be more focused on fighting inflammation rather than protecting the body from infection. Chronic inflammation can disrupt the body's growth pathways. Some molecules involved in the growth process, such as growth hormone, can be disrupted by inflammation. Additionally, inflammation can affect the development of the body's organs, tissues, and cells in ways that inhibit linear growth. This study aims to explore the role of chronic inflammation in the incidence of stunting. The literature search process was carried out on various databases (PubMed, Web of Sciences, EMBASE, Cochrane Libraries, and Google Scholar) regarding the role of chronic inflammation in the incidence of stunting. This study follows the preferred reporting items for systematic reviews and meta-analysis (PRISMA) recommendations. Chronic inflammation plays an important role in the occurrence of stunting in children. Chronic inflammation can influence various aspects that contribute to the growth and development of children's bodies, including nutrient absorption, growth hormone regulation, nutrient metabolism, and immune system function. This can result in stunted child growth, malnutrition, weight loss, and negative impacts on child well-being.