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All Journal Jurnal Komunitas Farmasi Nasional Kartika : Jurnal Ilmiah Farmasi
Rafika Sari
Program Studi Farmasi, Fakultas Kedokteran, Universitas Tanjungpura
Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences

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UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL DAUN GAHARU (Aquilaria microcarpa Baill.) TERHADAP BAKTERI Salmonella typhi dan Bacillus subtilis SECARA IN VITRO Rafika Sari; Frans Kristian; Inarah Fajriaty
Jurnal Komunitas Farmasi Nasional Vol. 1 No. 2 (2021): Jurnal Komunitas Farmasi Nasional
Publisher : Akademi Farmasi Yarsi Pontianak

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Abstract

Infections caused by pathogens such as salmonella typhi and Bacillus subtilis causes gastrointestinal infections and lead researchers to found a material that has potential as an antibacterial that has optimal efficacy by using the leaves of agarwood (Aquilaria microcarpa Baill.). The purpose of this study was to determine the compound class of secondary metabolites and antibacterial activity against salmonella typhi and bacillus subtilis of ethanol extract of agarwood leaves. The method used in the maceration and antibacterial activity test was diffusion method (Kirby-Bauer). Result are the ethanol extract of the agarwood leaves contain the compound flavonoids, saponins, tannins, steroids, and the solubility extract in water and ethanol are 21,80 ± 1,77% and 22,86 ± 2,78%. Shrinkage drying 26,25 ± 1,03%. Specific gravity 1% ethanol extract 1,0120mg/ml. Based on the research results antibacterial activity with the concentration of extract 300mg/ml, 400mg/ml, 500mg/ml toward salmonella typhi with an average diameter of inhibition zone 11,74 ± 0,44 mm, 13,55 ± 0,30 mm, 14,69 ± 0,67 mm and Bacillus subtillis with an average diameter of inhibition zone 10,29 ± 0,16 mm, 12,23 ± 0,21 mm, 13,56 ± 0,66 mm. The conclution is 500mg/ml concentration had a better antibacterial activity.
FICI VALUE OF AQUILARIA MALACCENSIS LEAVES EXTRACT AND AMOXICILLIN AGAINST PROTEUS MIRABILIS AND PSEUDOMONAS AERUGINOSA nobelia elok valentine; Pratiwi Apridamayanti; Rafika Sari
Kartika : Jurnal Ilmiah Farmasi Vol 6 No 2 (2018)
Publisher : Fakultas Farmasi Universitas Jenderal Achmad Yani, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/kjif.v6i2.157

Abstract

Abstract Infection is a common disease caused by microbes. The use of antimicrobial drugs such as Amoxicillin is most widely used in Indonesia, but has develop resistance. The resistance of Amoxicillin can be overcome by combining it with Karas leaves (Aquilaria malaccensis Lam.) which has an antibacterial activity. This research was conducted to know the value of Fractional Inhibitory Concentration Index (FICI) from the combination of ethanolic Karas leaves extract (A.malaccensis Lam.) with amoxicillin in Gram-negative bacteria test, that is, Proteus mirabilis and Pseudomonas aeruginosa. This research was used disc diffusion method by Kirby Bauer. Minimum Inhibitory Concentration (MIC) result of ethanolic karas leaves extract (A.malaccensis Lam.)  in P.mirabilis and P.aeruginosa was 0.5mg/ml. MIC’s result of amoxicillin in P. mirabilis and P.aeruginosa sequentially were 0.0039 and 0.0625 mg/ml. Then, evaluation of MIC value from combination of ethanolic karas leaves extract and amoxicillin (1/4 x MIC, 1/2 x MIC, 1 x MIC, 2 x MIC and 4 x MIC) showed that the combination of ethanolic karas leaves extract with amoxicillin has characteristics of FICI value on each bacteria, P. aeruginosa: 0.5 (synergistic) and P.mirabilis: 8 (antagonist) Keyword: antibacteria, Aquilaria malaccensis, amoxicillin, FICI
Co-Authors Fajriaty, Inarah Frans Kristian nobelia elok valentine Pratiwi Apridamayanti