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All Journal Kartika : Jurnal Ilmiah Farmasi
Pratiwi Apridamayanti
Program studi farmasi fakultas kedokteran universitas tanjungpura
Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Social Sciences

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FICI VALUE OF AQUILARIA MALACCENSIS LEAVES EXTRACT AND AMOXICILLIN AGAINST PROTEUS MIRABILIS AND PSEUDOMONAS AERUGINOSA nobelia elok valentine; Pratiwi Apridamayanti; Rafika Sari
Kartika : Jurnal Ilmiah Farmasi Vol 6 No 2 (2018)
Publisher : Fakultas Farmasi Universitas Jenderal Achmad Yani, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/kjif.v6i2.157

Abstract

Abstract Infection is a common disease caused by microbes. The use of antimicrobial drugs such as Amoxicillin is most widely used in Indonesia, but has develop resistance. The resistance of Amoxicillin can be overcome by combining it with Karas leaves (Aquilaria malaccensis Lam.) which has an antibacterial activity. This research was conducted to know the value of Fractional Inhibitory Concentration Index (FICI) from the combination of ethanolic Karas leaves extract (A.malaccensis Lam.) with amoxicillin in Gram-negative bacteria test, that is, Proteus mirabilis and Pseudomonas aeruginosa. This research was used disc diffusion method by Kirby Bauer. Minimum Inhibitory Concentration (MIC) result of ethanolic karas leaves extract (A.malaccensis Lam.)  in P.mirabilis and P.aeruginosa was 0.5mg/ml. MIC’s result of amoxicillin in P. mirabilis and P.aeruginosa sequentially were 0.0039 and 0.0625 mg/ml. Then, evaluation of MIC value from combination of ethanolic karas leaves extract and amoxicillin (1/4 x MIC, 1/2 x MIC, 1 x MIC, 2 x MIC and 4 x MIC) showed that the combination of ethanolic karas leaves extract with amoxicillin has characteristics of FICI value on each bacteria, P. aeruginosa: 0.5 (synergistic) and P.mirabilis: 8 (antagonist) Keyword: antibacteria, Aquilaria malaccensis, amoxicillin, FICI
Minimum Inhibitory Concentration Determination of Bambusa vulgaris Leaves Extract Against Skin and Digestive Diseases Bacteria Kelly Zhiang; Rafika Sari; Pratiwi Apridamayanti
Kartika : Jurnal Ilmiah Farmasi Vol 7 No 1 (2019)
Publisher : Fakultas Farmasi Universitas Jenderal Achmad Yani, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/kjif.v7i1.158

Abstract

Infections that are commonly happened in developing countries such as Indonesia are skin infection that caused by Staphylococcus aureus and Staphylococcus epidermidis, and digestive infection that caused by Bacillus subtilis and Bacillus cereus. The ethanol extract of Bambusa vulgaris leaves contained metabolite compounds that potential to have antibacterial activity. This study aimed to determine MIC (Minimum Inhibitory Concentration) value of ethanol extract of Bambusa vulgaris leaves against those four bacteria. The research was conducted by Kirby-Bauer disc diffusion method using ethanol extract of Bambusa vulgaris leaves with concentration variations of 80 mg/mL, 40 mg/mL, 20 mg/mL, 10 mg/mL, 5 mg/mL, 2.5 mg/mL, and 1.25 mg/mL. The results showed that ethanol extract of Bambusa vulgaris leaves can inhibit the growth of all four bacteria with MIC value against Staphylococcus aureus and Bacillus subtilis is 20 mg/mL, with inhibition zone diameter of 7,33 ± 0,416 mm and 6,32 ± 0,057 mm respectively. While the MIC value against Staphylococcus epidermidis and Bacillus cereus is 10 mg/mL, with inhibitory zone diameter obtained respectively 7,33 ± 0,416 mm and 6,07 ± 0,029 mm. The conclusion of this research was that ethanol extract of Bambusa vulgaris leaves had inhibition zone with MIC value 20 mg/mL against Staphylococcus aureus and Bacillus subtilis, and 10 mg/mL against Staphylococcus epidermidis and Bacillus cereus.Keywords: Ethanol extract of Bambusa vulgaris leaves, antibacterial, disc diffusion, MIC (Minimum Inhibitory Concentration)
Co-Authors Kelly Zhiang nobelia elok valentine Rafika Sari Rafika Sari