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All Journal JFARM (Jurnal Farmasi)
Nazwa Rahmadina
Universitas Lambung Mangkurat
Medicine & Pharmacology

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Potensi Madu Kelulut (Heterotrigona Itama) Sebagai Inhibitor IL6 Dengan pendekatan In Silico Samsul Hadi; Nazwa Rahmadina; Rizka Ramadani
JFARM - Jurnal Farmasi Vol. 2 No. 1 (2024)
Publisher : Yayasan Rahmatan Fiddunya Wal Akhirah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58794/jfarm.v2i1.628

Abstract

Inflamasi merupakan kondisi peradangan yang disertai rasa sakit dan demam. Pada umumnya obat antiinflamasi bekerja dengan inhibitor enzim siklooksigenase dan phospholipase A2 yang berperan dalam mensintesis mediator inflamasi seperti prostaglandin dan tromboksan. Berbagai penelitian dikembangkan untuk mencari agen terapi yang lebih efektif dan memiliki resiko yang lebih rendah baik gejala peradangan akut ataupun konsekuensi jangka panjang dari penyakit radang kronis. Salah satu pendekatan yang dilakuan adalah mengembangkan inhibitor IL6. Metode yang dilakukan adalah screening senyawa aktif menggunakan in silico. Software docking yang dipergunakan dalam penelitian ini adalah PLANTS dan visualisasi interaksi menggunakan discovery studio, bahan yang dipergunakan dalam penelitian ini adalah senyawa yang terkandung dalam madu kelulut (Heterotrigona itama) dan protein IL6 dengan kode 5FUC. Hasil dari penelitian ini adalah skor docking bernilai negative dibawah - 40, sehingga reaksi yang terjadi antara ligand dan protein akan berjalan spontan yaitu Ferulic acid: -45.783; p-Coumaric acid: -51.803; trans-Cinnamic acid: -75.999; Salicylic acid: -60.056. Kesimpulan dalam penelitian ini didapatkan senyawa dengan nilai skor terendah yaitu trans-Cinnamic acid.
Processing Of Liquid Waste From Dyeing Woven Yarns Using Activated Charcoal Rizka Aulia Ramadani; Nazwa Rahmadina; Samsul Hadi
JFARM - Jurnal Farmasi Vol. 2 No. 2 (2024)
Publisher : Yayasan Rahmatan Fiddunya Wal Akhirah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58794/jfarm.v2i2.681

Abstract

Textile liquid waste containing various chemicals and pollutants is a serious problem because it is difficult to achieve waste water quality standards in accordance with Minister of Health Regulation No. 416/1990. This research uses a literature review method to analyze various studies related to the use of activated charcoal in treating industrial liquid waste. Activated charcoal, with a carbon composition of 85-95%, is known to have high adsorption capabilities thanks to its porosity which can reach hundreds to thousands of square meters per gram. The process of making activated charcoal involves carbonization and activation of carbon materials at high temperatures. The method used was a review of articles between 2015 and 2023. The research results showed that activated charcoal was effective in reducing Chemical Oxygen Demand (COD) by up to 98.74%, which indicates a significant reduction in pollutant content. The adsorption process, which is an exothermic reaction, occurs more efficiently at low temperatures and increases with the length of contact time between activated charcoal and liquid waste. Conclusion: Textile industry liquid waste and variations in activated charcoal dosage and shaking time provide concrete data on the efficiency of activated charcoal in dealing with water pollution, offering a sustainable solution for industrial liquid waste management.
Use Of Natural Dyes From Plants In Coloring Woven Yarns Nazwa Rahmadina; Rizka Aulia Ramadani; Samsul Hadi
JFARM - Jurnal Farmasi Vol. 2 No. 2 (2024)
Publisher : Yayasan Rahmatan Fiddunya Wal Akhirah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58794/jfarm.v2i2.682

Abstract

The use of natural dyes as an environmentally friendly alternative to reduce the use of synthetic dyes which have a negative impact on the environment. Natural dyes can be obtained from various natural sources such as plants, animal waste, and minerals, with plants being the most common source. Plant pigments such as anthocyanins, tannins, flavonoids, and chlorophyll provide a variety of colors that can be used for coloring. The natural dyeing process involves four stages: making the dye solution, fabric preparation, dyeing, and fixation. Testing the quality of natural dyes includes color visualization tests, color aging, color differences and fastness to washing. The methodology for writing this article is a literature study, reviewing various related research from 2013 to 2023. The results show that several plants such as Tarum, Coconut, Secang, Noni, Turmeric, and Shallots can produce colors such as dark blue, brownish cream, red , yellow, and brownish orange on fabric. In conclusion, natural dyes not only support environmental sustainability but also offer a safe and low-cost coloring alternative, although there are challenges in the manufacturing and application process of these natural dyes.
Co-Authors Rizka Aulia Ramadani Rizka Ramadani Samsul Hadi Samsul Hadi