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Fitri Octaviana
Departemen Neurologi FK Universitas Indonesia/RSUPN Dr. Cipto Mangunkusumo, Jakarta
Health Professions Medicine & Pharmacology Neuroscience

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ENSEFALITIS ANTIRESEPTOR NMDA: ENSEFALITIS DENGAN GEJALA AWAL PSIKOSIS Riwanti Estiasari; Darma Imran; Kartika Maharani; David Pangeran; Fitri Octaviana; Dewi Wulandari
NEURONA Vol 35 No 1 (2017)
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v35i1.35

Abstract

     ANTI-NMDA RECEPTOR ENCEPHALITIS: ENCEPHALITIS PRESENTING WITH EARLY PSYCHOSIS SYMPTOMSABSTRACTAnti N-methyl-D-aspartate (NMDA) receptor encephalitis is seldom found in Indonesia. The atypical initial presentation of psychosis and cognitive disturbance results in underdiagnosed, or even undiagnosed case. This report described a 12-year-old girl presenting with initial psychiatric symptom followed by seizure and oropharyngeal dystonia. Anti-NMDA receptor antibody test carried out on both serum and  cerebrospinal  fluid (CSF) were positive and  no other pathogen was detected in the CSF. Clinical improvement was seen following the third day of methylprednisolone administration. This case demonstrates the importance of considering anti-NMDA receptor encephalitis or the other autoimmune encephalitis as the differential of infective encephalitis. Anti-NMDA receptor antibody test, which can already be performed in Indonesia, will greatly guide to the definitive diagnosis.Keywords: Encephalitis, NMDA, oropharyngeal dystonia, psychiatricABSTRAKEnsefalitis antireseptor N-metil-D-aspartat (NMDA) masih jarang ditemukan di Indonesia. Gejala awal yang tidak khas berupa psikosis dan gangguan kognitif menyebabkan keterlambatan diagnosis, atau bahkan tidak terdiagnosis, ensefalitis jenis ini. Berikut dilaporkan kasus seorang perempuan 12 tahun dengan gejala awal berupa gejala psikiatrik yang diikuti dengan kejang dan munculnya distonia orofaring. Pemeriksaan antibodi antireseptor NMDA pada serum dan cairan serebrospinal (CSS) positif dan tidak ditemukan patogen lain pada pemerikaan CSS. Perbaikan klinis terlihat setelah pemberian metilprednisolon selama 3 hari. Kasus ini memperlihatkan pentingnya mempertimbangkan diagnosis ensefalitis antireseptor NMDA atau ensefalitis autoimun lainnya sebagai diagnosis banding pada kasus ensefalitis infeksi. Oleh karena itu, pemeriksaan antibodi antireseptor NMDA yang telah dapat dilakukan di Indonesia akan sangat membantu proses penegakan diagnosis.Kata kunci: Distonia orofaring, ensefalitis, NMDA, psikiatrik
INTERAKSI HORMON DAN EPILEPSI Ahmad Sulaiman Alwahdy; Astri Budikayanti; Fitri Octaviana; Donny Hamid
NEURONA Vol 37 No 2 (2020)
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v37i2.115

Abstract

HORMONE AND EPILEPSY INTERACTIONABSTRACTHormones are signaling chemical molecules between cells that circulated in blood within the human body and play important roles for human being. Unfortunately, not all their functions are known, especially in epilepsy. Studies reported interactions between hormones and epilepsy, also with antiepileptic drugs (AEDs). For example, seizures may be induced by estrogen, whileAEDs can decrease hormone level by inducing enzyme in P450 cytochrome and accelerating hormone clearance.These conditions are known as tridirectional interactions. Understanding the interactions between hormones, epilepsy and AEDs would raise an awareness and insight for clinicians especially neurologist for basic knowledges as considerations in treating patients with epilepsy.Keyword: Antiepileptic drugs, epilepsy, hormone, seizureABSTRAKHormon merupakan molekul pembawa pesan kimiawi antar sel yang berada dalam tubuh manusia, beredar di dalam darah dan sangat penting bagi kehidupan manusia. Perannya pada epilepsi belum seluruhnya diketahui, akan tetapi berbagai penelitian yang ada menunjukan adanya interaksi antara hormon dan epilepsi begitu juga terhadap obat antiepilepsi (OAE). Sebagai contoh, bangkitan epilepsi dapat dicetuskan oleh estrogen, namun beberapa OAE yang merupakan penginduksi enzim sitokrom P450 di hati, dapat menurunkan kadar hormon di dalam tubuh dan juga mempercepat pembersihan hormon terutama hormon steroid seks. Hubungan ketiga faktor ini menciptakan hubungan yang disebut hubungan tridireksional. Dengan memahami mengenai interaksi yang terjadi antara hormon, epilepsi dan OAE, diharapkan dapat membuka wawasan bagi neurologis untuk memiliki pengetahuan dasar sebagai pertimbangan dalam tata laksana pasien epilepsi.Kata kunci: Bangkitan,epilepsi, hormon, obat antiepilepsi
PENDEKATAN DIAGNOSIS DAN TATA LAKSANA MULTIDISIPLIN JANGKA PANJANG PADA NEUROPATI HEREDITER: CHARCOT MARIE TOOTH Putri Widya Andini; Manfaluthy Hakim; Fitri Octaviana; Luh Ari Indrawati; Winnugroho Wiratman; Triana Ayuningtyas; Ahmad Yanuar Safri
NEURONA Vol 38 No 1 (2020)
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Hereditary neuropathy is the most common inherited neuromuscular diseases, with Charcot Marie Tooth being the most common form. It is characterised by degeneration of peripheral sensory and motor nerves due to axonal degeneration or demyelination. The diagnosis of hereditary neuropathy requires comprehensive history taking including family history to determine the mode of inheritance, clinical and neurophysiological examination, and genetic testing. This review provides a diagnostic approach and long-term multidisciplinary management in patients with suspected hereditary neuropathy. Keywords: Charcot Marie Tooth, genetics, neuropathy
Co-Authors Ahmad Sulaiman Alwahdy Darma Imran David Pangeran Dewi Wulandari Donny Hamid Kartika Maharani Luh Ari Indrawati Manfaluthy Hakim Nurwahyuni, Atik Putri Widya Andini Riwanti Estiasari Safri, Ahmad Yanuar Triana Ayuningtyas Winnugroho Wiratman