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All Journal Panrita Abdi - Jurnal Pengabdian pada Masyarakat Parapemikir Jurnal Ilmiah Farmasi Borneo Journal of Pharmacy
Wahyudin Bin Jamaludin
Universitas Borneo Lestari
Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Physics Other

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Anti-Rheumatoid Arthritis Activity of 96% Ethanol Extract of Eleutherine bulbosa Bulbs with Arthritis Induction Adjuvant Method Rahmi Muthia; Helmina Wati; Wahyudin Bin Jamaludin; Kartini Kartini; Finna Setiawan; Gina Rizki Zanirah
Borneo Journal of Pharmacy Vol. 6 No. 4 (2023): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v6i4.4704

Abstract

An autoimmune condition known as rheumatoid arthritis (RA) results in chronic joint inflammation. Side effects that occur during long-term RA treatment are dangerous. Therefore, many people prefer herbal medicines, estimated to have lower side effects; one such herb is bawang dayak (Eleutherine bulbosa Urb.) bulbs. This study aimed to determine the class of compounds and the effective dose of the 96% ethanol extract of E. bulbosa bulbs, which had an anti-RA effect in the Wistar strain with the Adjuvant Induced Arthritis (AIA) model. Eleutherine bulbosa bulb extract was macerated with 96% ethanol. In the tests with extract doses of 100, 200, and 400 mg/KgBW and methylprednisolone 15 mg/KgBW, the induction used Complete Freund's Adjuvant (CFA). Treatment was provided from day eight through 21 of the test's 21-day duration. Phytochemical screening results contain alkaloids, flavonoids, phenols, quinones, saponins, steroids, and tannins. The percentage inhibition of edema volume and joint thickness, respectively, extract doses of 100, 200, 400 mg/KgBW, and methylprednisolone 15 mg/KgBW were 27.9585%, 49.3446%, 53.3239%, and 58.4629%; as well as 64.9809%, 73.8022%, 74.1444%, and 74.1825%. After analyzing the results, it was determined that E. bulbosa bulb extracts in 96% ethanol can treat RA at effective 200 and 400 mg/KgBW (p-value <0.05).
EDUKASI DAN PELATIHAN PENGOLAHAN TEH DARI DAUN KARAMUNTING (RHODOMYRTUS TOMENTOSA) DI KELURAHAN LANDASAN ULIN UTARA M. Andi Chandra; Wahyudin Bin Jamaludin
Panrita Abdi - Jurnal Pengabdian pada Masyarakat Vol. 8 No. 1 (2024): Jurnal Panrita Abdi - Januari 2024
Publisher : LP2M Universitas Hasanuddin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/pa.v8i1.23315

Abstract

The focus of community service activities is to give knowledge and information to the public about education and training on tea processing from karamunting (Rhodomyrtus Tomentosa) leaves. Activities in educational efforts related to the use of medicinal plants from Kalimantan resources and training on processing tea from karamunting leaves. This program was attended by 20 people. Extension methods in the form of lectures and direct demonstrations. Participants who participated in this activity focused only on the people who were members of the KWT (Kurnia Lestari). The media is used in the form of leaflets and brochures. Evaluation of the knowledge that has been given uses a pre-test and post-test system. Based on the pretest value, it can be seen that knowledge is 90%, while the post-test results show an increase in knowledge to (98%). The education and training program for processing tea from karamunting (Rhodomyrtus Tomentosa) leaves is considered effective as a preventive measure against the use of traditional medicine.  ---   Fokus dari kegiatan pengabmas yaitu memberikan pengetahuan kepada masyarakat mengenai edukasi dan pelatihan pengolahan teh dari daun karamunting (Rhodomyrtus Tomentosa). Kegiatan berupa edukasi tentang pemanfaatan tanaman berkhasiat obat sumber daya Kalimantan dan pelatihan pengolahan the dari daun karamunting. Program ini dihadiri 20 orang. Metode Penyuluhan berupa ceramah dan demonstrasi secarang langsung. Peserta yang berpartisipaso dalam kegiatan ini berfokus hanya pada masyarakat yang tergabung dalam KWT (kurnia lestari). Media yang digunakan berupa leaflet dan brosur. Evaluasi terhadap pengetahuan yang telah diberikan menggunakan sistem pre-test dan post test. Berdasarkan nilai pretest terlihat bahwa pengetahuan sebesar 90%, sedangkan hasil post-test menunjukkan adanya peningkatan pengetahuan menjadi (98%). Program edukasi dan pelatihan pengolahan teh dari daun karamunting (Rhodomyrtus Tomentosa) dinilai efektif sebagai tindakan preventif penggunaan obat tradisional.
UJI AKTIVITAS ANTIBAKTERI EKSTRAK METANOL DAUN RAMANIA (Bouea macrophylla Griffith) TERHADAP BAKTERI Staphylococcus epidermidis Murniati Murniati; Fitriyanti Fitriyanti; Wahyudin Bin Jamaludin
Parapemikir : Jurnal Ilmiah Farmasi Vol 13, No 1 (2024): Parapemikir : Jurnal Ilmiah Farmasi
Publisher : Pusat Penelitian dan Pengabdian Masyarakat Politeknik Harapan Bersama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30591/pjif.v13i1.5786

Abstract

Daun ramania (B. Macrophylla Griffith) memiliki banyak manfaat dalam bidang kesehatan. Salah satu pemanfaatan sebagai tumbuhan obat yaitu dapat berefek sebagai antibakteri. Tujuan dari penelitian ini adalah untuk mengetahui senyawa metabolit sekunder yang terkandung di dalam ekstrak metanol daun Ramania (B.macrophylla Griffith) dan untuk mengetahui aktivitas antibakteri ekstrak metanol daun ramania (B. macrophylla Griffith) dalam menghambat pertumbuhan bakteri S. epidermidis. Uji aktivitas antibakteri ekstrak dilakukan dengan metode difusi sumuran terhadap bakteri S. epidermidis dengan 5 konsentrasi yaitu konsentrasi 10%, 20%, 30%, 40% dan 50%. Kontrol positif Klindamisin 2µg/disk dan kontrol negatif Na-CMC 0,5%. Hasil skrining fitokimia ekstrak metanol daun Ramania (B. macrophylla Griffith) mengandung flavonoid, tanin, saponin, steroid, dan fenol. Hasil uji aktivitas antibakteri ekstrak metanol  daun ramania (B. macrophylla Griffith) memperoleh nilai rata-rata diameter zona hambat dari konsentrasi 10% yaitu 9,875 dengan kategori sedang, pada konsentrasi 20%, 30%, 40%, dan 50% yaitu memiliki nilai masing-masing 11,338 mm; 13,44 mm; 16,025 mm; 16,4 mm dengan kategori kuat. Sedangkan pada kontrol positif Klindamisin 2 µg/disk yaitu 24,55 mm dengan kategori sangat kuat dan kontrol negatif Na-CMC 0,5% tidak memiliki daya hambat. Berdasarkan hasil yang diperoleh, dapat disimpulkan bahwa ekstrak metanol daun ramania (B. Macrophylla Griffith) mempunyai kemampuan sebagai antibakteri dalam kategori sedang, kuat, sampai sangat kuat dalam menghambat bakteri S. epidermidis.
Co-Authors Finna Setiawan Fitriyanti, Fitriyanti Gina Rizki Zanirah Helmina Wati Kartini Kartini M. Andi Chandra Murniati Murniati Rahmi Muthia