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All Journal International Journal Of Science, Technology & Management (IJSTM) Jurnal Sains dan Kesehatan Jurnal Bakti Nusantara
Ziza Putri Aisyia Fauzi
Department Of Pharmacology, Faculty Of Pharmacy, Universitas Sumatera Utara, Medan, 20155, Indonesia
Aerospace Engineering Agriculture, Biological Sciences & Forestry Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Mechanical Engineering Medicine & Pharmacology Transportation Other

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Toxic Effect Of The Compound {1,3 Bis (P-Hydroxyphenyl) Urea} On Triiodothyronine (T3) Hormone Levels In Pregnant White Rats (Rattus Norvegicus L.) Ziza Putri Aisyia Fauzi; Urip Harahap; Yuandani Yuandani; Syukur Berkat Waruwu; Hari Purnomo; Denny Satria
International Journal of Science, Technology & Management Vol. 4 No. 1 (2023): January 2023
Publisher : Publisher Cv. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46729/ijstm.v4i1.719

Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most commonly prescribed drugs for pregnant women to treat fever, pain and inflammation. Specific NSAIDs can displace thyroid hormone from its protein binding sites, causing thyroid hormone measurement problems. {1,3 bis (p-Hydroxyphenyl)urea} is a modified p-aminophenol compound with potent analgesic and anti-inflammatory activity and less toxicity. This study is a follow-up to previous research to observe the toxic effect on triiodothyronine hormone levels after administration of {1,3 bis(p-Hydroxyphenyl)urea} compound in pregnant white rats. The toxic effect test was carried out by giving the test preparation to pregnant rats, which had been divided into five groups, namely the normal control group (CMC-Na 0.5%), the positive control (Gabapentin 50 mg/kg BW), Compound {1.3 bis (p- Hydroxyphenyl)urea} at a dose of 50 mg/kg BW, 500 mg/kg BW and 1000 mg/kg BW. Mice were given the test preparation every day from the 6th to the 15th day of pregnancy. Blood was taken on the 16th day, and T3 hormone levels were measured using the ELISA method. The results showed that the T3 hormone levels in the {1,3 bis(p-Hydroxyphenyl)urea group had no significant difference from the normal control group, so it was concluded that {1,3 bis(p-Hydroxyphenyl)urea) did not have a significant effect on the hormone T3.
Antimicrobial Activity Test of Ethanol Extract of Senggani Leaves (Melastoma malabraticum L) Against Propionibacterium Acnes and Staphylococcus Epidermidis Haris Munandar Nasution; Zulmai Rani; Ziza Putri Aisyia Fauzi; Ahmad Rasyid Ridho
Jurnal Sains dan Kesehatan Vol. 6 No. 2 (2024): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v6i2.2208

Abstract

Senggani leaves are a plant that can be found in Indonesia, including hilly locations. The people of Marendal, Patumbak subdistrict, believe that senggani leaves may heal minor skin wounds. The goal of this study was to identify the class of secondary metabolite chemical compounds and their antibacterial efficacy against the microorganisms Propionibacterium acnes and Staphylococcus epidermidis at 5, 10, and 20% concentrations. The ethanol extract of senggani leaves contains secondary metabolite compounds with antibacterial activity. According to the antibacterial test results, a 20% ethanol extract of senggani leaves is effective against Propionibacterium with a diameter of 10.7 mm, a 10% in the medium category with a diameter of 9.27 mm, and a 5% in the medium category with a diameter of 8.8 mm. Meanwhile, the diameter of Staphylococcus epidermidis at a 20% was 8.77 mm in the medium category, 8.37 mm at 10%, and 8.6 mm at a 5% concentration.   Keywords:          Propionibacterium acnes, Senggani leaves, Staphylococcus epidermidis
Edukasi Kesehatan dan Obat Hipertensi pada Lansia Dinda Sari Utami; Ziza Putri Aisyia Fauzi; Zulmai Rani
Jurnal Bakti Nusantara Vol. 1 No. 2 (2023): Jurnal Bakti Nusantara
Publisher : Pustaka Media Publishing

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Abstract

Hipertensi adalah penyakit yang umum terjadi, terutama pada kalangan lanjut usia atau lansia. Hipertensi yang terdapat pada lansia sebagian besar adalah tekanan darah sistolik terisolasi (HST). International Society of Hypertension (ISH) tahun 2020 menyebutkan bahwa, peningkatan tekanan darah penyebab utama kematian secara global, menyebabkan 10.4 juta kematian per tahun. Angka global diperkirakan sebanyak 1.39 miliar orang mengidap hipertensi pada tahun 2010. Sasaran langsung kegiatan adalah pra lanjut usia (45-59 tahun), lanjut usia (60-69 tahun), dan lanjut usia risiko tinggi (lanjut usia >70 tahun atau usia >= 60 tahun dengan masalah kesehatan). Tujuan dari pengabdian kepada masyarakat ini adalah agar para lansia lebih memahami tentang hipertensi. Metode dalam pengabdian masyarakat ini adalah edukasi berbentuk sosialisasi mengenai hipertensi dan praktik pemeriksaan tekanan darah langsung kepada mitra. Hasil dalam kegiatan pengabdian masyarakat berupa meningkatnya pengetahuan lansia mengenai hipertensi.
Co-Authors Ahmad Rasyid Ridho Denny Satria Dinda Sari Utami Hari Purnomo Haris Munandar Nasution Syukur Berkat Waruwu Urip Harahap Yuandani Yuandani Zulmai Rani