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All Journal Indonesian Journal of Chemistry
Ace Tatang Hidayat
Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jl. Raya Bandung-Sumedang Km. 21, Jatinangor, Sumedang 45363, Indonesia; Central Laboratory of Universitas Padjadjaran, Jl. Raya Bandung-Sumedang, Km. 21,
Chemical Engineering, Chemistry & Bioengineering Chemistry

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Cytotoxic Dammarane-Type Triterpenoids from Aglaia cucullata Peel Fruit Intan Hawina Anjari; Desi Harneti; Kindi Farabi; Al Arofatus Naini; Ace Tatang Hidayat; Risyandi Anwar; Hadi Kuncoro; Mohamad Nurul Azmi; Unang Supratman
Indonesian Journal of Chemistry Vol 24, No 1 (2024)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.83694

Abstract

Four triterpenoids, known as dammarane-type, dammaradienone (1), 20(S),25-epoxy-5α-dammar-20-en-3-one (2), 20(S)-5α-dammar-24-en-3α,20-diol-3-acetate (3) and 3α-acetyl-20S,24S-epoxy-25-hydroxydammarane (4), were isolated from Aglaia cucullata peel fruit. The structures of isolated compounds were identified based on their HR-TOFMS data and extensive NMR spectroscopic analysis, as well as compared with literature data. Compounds 1-4 were assessed for cytotoxic effects against HeLa cervical and B16-F10 melanoma skin cancer cells. All compounds showed moderate to weak activity against B16-F10 cancer cells, while compound 2 exhibited the strongest activity against HeLa cancer cells with IC50 of 7.10 µg/mL indicating that the existence of an epoxy moiety at the side chain increases the cytotoxicity to HeLa cells.
Co-Authors Al Arofatus Naini Desi Harneti Putri Huspa Hadi Kuncoro Intan Hawina Anjari Kindi Farabi Mohamad Nurul Azmi Risyandi Anwar Unang Supratman