Indonesian Journal of Chemistry
Vol 24, No 1 (2024)

Cytotoxic Dammarane-Type Triterpenoids from Aglaia cucullata Peel Fruit

Intan Hawina Anjari (Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jl. Raya Bandung-Sumedang Km. 21, Jatinangor, Sumedang 45363, Indonesia)
Desi Harneti (Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jl. Raya Bandung-Sumedang Km. 21, Jatinangor, Sumedang 45363, Indonesia)
Kindi Farabi (Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jl. Raya Bandung-Sumedang Km. 21, Jatinangor, Sumedang 45363, Indonesia
Central Laboratory of Universitas Padjadjaran, Jl. Raya Bandung-Sumedang, Km. 21, )
Al Arofatus Naini (Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jl. Raya Bandung-Sumedang Km. 21, Jatinangor, Sumedang 45363, Indonesia)
Ace Tatang Hidayat (Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jl. Raya Bandung-Sumedang Km. 21, Jatinangor, Sumedang 45363, Indonesia
Central Laboratory of Universitas Padjadjaran, Jl. Raya Bandung-Sumedang, Km. 21, )
Risyandi Anwar (Herbal Medicine Research, Department of Paediatric Dentistry, Faculty of Dental Medicine, University of Muhammadiyah Semarang, Semarang 50272, Indonesia)
Hadi Kuncoro (Faculty of Pharmacy, Universitas Mulawarman, Samarinda 75123, Indonesia)
Mohamad Nurul Azmi (School of Chemical Sciences, Universiti Sains Malaysia, 11800 Minden, Penang, Malaysia)
Unang Supratman (Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jl. Raya Bandung-Sumedang Km. 21, Jatinangor, Sumedang 45363, Indonesia
Central Laboratory of Universitas Padjadjaran, Jl. Raya Bandung-Sumedang, Km. 21, )

Article Info

Publish Date
01 Feb 2024

Abstract

Four triterpenoids, known as dammarane-type, dammaradienone (1), 20(S),25-epoxy-5α-dammar-20-en-3-one (2), 20(S)-5α-dammar-24-en-3α,20-diol-3-acetate (3) and 3α-acetyl-20S,24S-epoxy-25-hydroxydammarane (4), were isolated from Aglaia cucullata peel fruit. The structures of isolated compounds were identified based on their HR-TOFMS data and extensive NMR spectroscopic analysis, as well as compared with literature data. Compounds 1-4 were assessed for cytotoxic effects against HeLa cervical and B16-F10 melanoma skin cancer cells. All compounds showed moderate to weak activity against B16-F10 cancer cells, while compound 2 exhibited the strongest activity against HeLa cancer cells with IC50 of 7.10 µg/mL indicating that the existence of an epoxy moiety at the side chain increases the cytotoxicity to HeLa cells.

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Journal Info
Indonesian Journal of Chemistry
Website

Abbrev

ijc

Publisher

Universitas Gadjah Mada

Subject

Chemical Engineering, Chemistry & Bioengineering Chemistry

Description

Indonesian Journal of Chemistry is an International, peer-reviewed, open access journal that publishes original research articles, review articles, as well as short communication in all areas of chemistry including applied chemistry. The journal is accredited by The Ministry of Research, Technology ...