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All Journal JURNAL FARMASIMED (JFM) Jurnal Sains dan Kesehatan Usadha Parapemikir Jurnal Ilmiah Farmasi Kunir: Jurnal Farmasi Indonesia (KJFI)
Listina, Osie
Program Studi Farmasi S-1, Universitas Bhamada Slawi, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Physics Public Health

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Journal : Usadha

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OPTIMASI EFEK ANALGETIK SIRUP EKSTRAK DAUN BELUNTAS (Pluchea Indica (L.) Less.) TERHADAP MENCIT JANTAN PUTIH (Mus Musculus) DENGAN METODE RANGSANG PANAS Osie Listina
Usadha Vol 1 No 2 (2022): Usadha: Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

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Abstract

Beluntas plants generally grow wild in dry areas and have enormous benefits in treatment such as eliminating body odor, increasing appetite, overcoming pain and reducing fever. Beluntas leaves contain flavonoids which help the process of relieving pain. Pain is an uncomfortable sensory and emotional feeling related to (threatening) tissue damage. This study aimed to determine whether there is an analgesic effect of beluntas leaves extract syrup. This study was experimental using 25 mice which were divided into 5 groups. The negative control group was given aquades, positive control group was given paracetamol, and 3 experimental groups were given beluntas leaves extract syrup, each with a dose of 150mg/kgBB, 300 mg/kgBB, and 600mg/kgBB. Testting of analgesic effect was conducted by giving pain to test animals, in the form of hot stimulus with temperature of 550C. The response of the mice observed was the licking of the feet and or jumping. Observations were made for 1 minute. Observations were made before giving the test substance, and then successively in the 30, 60, 90, and 120 minutes after administration of the test substance. The results showed the number of responses to pain stimuli in the group of mice given beluntas leaves extract syrup began to decline in the 30 minute and continued to give effect in the 60 minute. In the 90th minute the analgesic effect began to decline, but it still showed the analgesic effect.At the second and third concentrations (300mg/kgBW : 600mg/kgBW) syrup of beluntas leaf extract (Pluchea indica (L.) Less.) had the best analgesic effect.
Formulasi dan Uji Fisik Ekstrak Biji Alpukat (Persea aericana Mill) dengan Cangkang Telur Sebagai Body Scrub Arifina Fahamsya; Osie Listina
Usadha Vol 2 No 3 (2023): Usadha: Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v2i3.7478

Abstract

Avocado seeds contain secondary metabolite compounds that have many benefits such as alkaloids, flavonoids, saponins, tannins, and vitamin E which can be utilized for skin care. Body scrub is a skin care preparation in the form of a liquid emulsion consisting of an oil phase and an aqueous phase with coarse grains that are useful for moisturizing, cleaning the surface of the skin pores, removing dead skin cells as well as being a carrier for efficacious substances into the skin. This study aims to see a body scrub preparation formulation of avocado seed ethanol extract that meets the physical quality requirements and determination of the potential irritation of body scrubs. The method of making avocado seed ethanol extract is done by maceration and remaceration. Four formulations were made, namely F0 base, F1 1%, F2 5% and F3 10%. The physical evaluation carried out was organoleptical test, pH test, homogeneity test, spreadability test, adhesion test, viscosity test, and irritation test. The results showed that the body scrub preparation made had met the requirements of the physical quality test and the value of the degree of irritation of the body scrub was 0.3-1.3 which means very mild irritation to mild irritation.
Co-Authors Afina Afina Agung Nur Cahyanta Alfiraza, Ery Nourika Arifina Fahamsya Desi Sri Rejeki Devi Ika Kurnianingtyas Solikhati Eti Purwati Isti Qomah Lailiana Garna Nurhidayati Lutfatul Khasanah Oktariani Pramiastuti Pramiastuti, Oktariani Tomy Sugiarto Gautama