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All Journal JSFK (Jurnal Sains Farmasi & Klinis) Sriwijaya Journal of Internal Medicine
Annisa Diyan Meitasari
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Formulation and Activity of Sunscreen Cream from Ethanol Extract of Calendula officinalis L Flowers Sholichah Rohmani; Luthfia Mar’atushsholihah; Ulfa Afrinurfadhillah Darojati; Annisa Diyan Meitasari; Bela Novita Amaris Susanto
JSFK (Jurnal Sains Farmasi & Klinis) Vol 11 No 1 (2024): J Sains Farm Klin 11(1), April 2024
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.11.1.48-57.2024

Abstract

Sunscreen made of natural ingredients is an alternative to protect the skin from excess UV radiation and a substitute for chemical products that have side effects. It was reported that Calendula officinalis L. has flavonoid and saponin metabolite compounds which function as photoprotective agents. This research aims to formulate sunscreen cream and examine the effect of variations in Calendula officinalis L flower extract (5%;7%;10% w/v) on physicochemical properties, stability, and values of the Sun Protecting Factor (SPF) in vitro using UV-Vis spectrophotometry and in vivo using wistar line rat test animals to see the time of formation of Minimum Erythema Dose (MED). It has been proven that variations in the concentration of Calendula officinalis L. extract affected the physicochemical properties, such as pH value, viscosity, spreadability, and adhesion strength. However, the overall results of the physicochemical properties still met the requirements. Variations in extract concentration affected the SPF value. In vitro SPF test showed the minimum protection category for F1, extra protection for F2, maximum protection for F3, and no protection for F0. Meanwhile, the in vivo SPF test showed the minimal protection category for F1, medium protection for F2, extra protection for F3, and no protection for F0.
Antibacterial Potential of Dewandaru Leaves (Eugenia uniflora L.) Against Escherichia coli: In Vitro Study Setiyanto, Riyan; Annisa Diyan Meitasari; Sinta Cantika Natasya; Dewi Weni Sari
Sriwijaya Journal of Internal Medicine Vol. 2 No. 1 (2024): Sriwijaya Journal of Internal Medicine
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjim.v2i1.138

Abstract

Introduction: Escherichia coli is a pathogenic Gram-negative bacteria that commonly causes digestive tract infections, including diarrhea. Continuous use of antibiotics has led to an increase in bacterial resistance. Dewandaru leaves (Eugenia uniflora L.) have been known to have antibacterial activity against several pathogenic bacteria. This study aims to evaluate the antibacterial activity of dewandaru leaf extract against E. coli in vitro. Methods: Dewandaru leaves were extracted using the maceration method with 96% ethanol. The antibacterial activity test was carried out using the Kirby-Bauer disk diffusion method with gentamicin as a positive control and sterile NaCl as a negative control. The diameter of the inhibition zone was measured and analyzed statistically. Results: Dewandaru leaf extract shows antibacterial activity against E. coli with a significant zone of inhibition. An extract concentration of 80% showed moderate antibacterial activity, while concentrations of 40% and 60% did not show antibacterial activity. Conclusion: Dewandaru leaves have the potential to be a natural antibacterial agent against E. coli. Further studies are needed to isolate and identify the active compounds and evaluate the effectiveness and safety of dewandaru leaf extract in vivo.
Co-Authors Bela Novita Amaris Susanto Dewi Weni Sari Luthfia Mar’atushsholihah Setiyanto, Riyan Sholichah Rohmani Sinta Cantika Natasya Ulfa Afrinurfadhillah Darojati