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dharma yanti
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PERBANDINGAN AKTIVITAS ANTIOKSIDAN DAN TOKSISITAS ANTARA DAGING BUAH, KULIT BAGIAN DALAM DAN KULIT BAGIAN LUAR BUAH MANGGIS ( GARCINIA MANGOSTANA L.) dharma yanti
Jurnal Ayurveda Medistra Vol 3 No 1 (2021): Jurnal Ayurveda Medistra
Publisher : STIKes Medistra Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51690/medistra-jurnal123.v3i1.35

Abstract

Abstract Mangosteen (Garcinia mangostana L.) is a fruit that has the potential to have medicinal properties and has been used in empirical treatment (experience). Based on previous experiments, mangosteen rind contains xanthones which have antioxidant, anti-tumor, anti-inflammatory, anti-allergenic, antibacterial, anti-fungal, anti-malarial and anti-cancer activities. Previous experiments focused more on the skin, but no one has tested and compared the activity of the fruit parts. This experiment aims to compare the antioxidant activity and toxicity between the pulp, inner skin and outer skin of the mangosteen fruit. This is intended to determine the best antioxidant activity and toxicity between the three parts of the mangosteen fruit so that it can be used as a basis for further testing of their activity as an ingredient Antioxidant activity testing was carried out using the DPPH (2,2-Diphenyl-1-Picrylhydrazyl) free radical reduction method. A substance is declared to have antioxidant activity if the IC50 value is <150µg / ml, the smaller the IC50, the stronger the antioxidant activity. In the toxicity test of a substance it is said to be toxic if the LC50 is <1000 µg / ml, the smaller the LC50 value, the stronger the toxicity. The toxicity test was carried out by the Brine Shrimp Lethality Test (BSLT) method using Artemia salina L. shrimp larvae. Antioxidant test results were statistically processed using linear regression to obtain the IC50 value, while the results of the toxicity test were processed by computerized probit analysis using SPSS 14 software for windows to determine the LC50 value. Based on the antioxidant activity testing, it was concluded that the three samples had the potential for antioxidant activity with IC50 values ​​respectively, 1.95 µg / ml (outer shell extract); 7.00 µg / ml (inner skin extract); 51.10 µg / ml (mangosteen pulp extract). Based on the results of the toxicity test, the LC50 values ​​of the samples were respectively 6.29 µg / ml (inner shell extract); 9.17 µg / ml (outer skin extract) and 1158.47 µg / ml (mangosteen pulp extract), so it can be concluded that the toxic parts are the outer and inner skin parts while the mangosteen fruit is not toxic.
IDENTIFIKASI SENYAWA ANTI MIKROBA EKSTRAK ETANOL BATANG BROTOWALI (Tinospra crispa (L.) TERHADAP Staphylococcus aureus, Bacillus substillis, DAN Candida albicans DENGAN METODE KLT BIOAUTOGRAFI dharma yanti; Nunung Nurhayati
Jurnal Ayurveda Medistra Vol 4 No 1 (2022): Jurnal Ayurveda Medistra
Publisher : STIKes Medistra Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51690/medistra-jurnal123.v4i1.54

Abstract

The brotowali plant (Tinospra crispa (L.) has empirically been used for diseases such as fever, pain relief, lowering sugar levels and as an external medicine for wounds and itching. Brotowali stems are reported to be used to treat infectious diseases because they contain flavonoid compounds, saponins , tannins, glycosides .This study aims to identify the approximate compounds that have antimicrobial activity using bioautography, GCMS and infrared spectrophotometry methods. Extraction was carried out with 96% ethanol solvent by maceration method and partitioned using n-hexane and ethyl acetate. Antimicrobial activity was tested on 96% ethanol extract, n-hexane fraction and ethyl acetate fraction using the paper disc diffusion method against Staphylococcus aureus, Bacillus substillis, and Candida albicans microbes. The results obtained showed that 96% ethanol extract, hexan fraction and water fraction did not show anti-bacterial activity. TLC results of the ethyl acetat fraction produced 4 spots with the largest diameter of the inhibition zone against microbes, so that the testing of the ethyl acetat fraction was continued with the bioautography method. The bioautography test showed that the antimicrobial activity was visible at hrf 42.8, then the extract was analyzed by infrared spectrophotometry and GCMS. Analysis with infrared spectrophotometry showed the presence of functional groups C=O, CH stretch, alkene(C=C), OH. The results of the GCMS analysis and the prediction of the identity of the peaks obtained using the database showed that the largest peak was octanoic acid, 4 hydroxy-3-methoxy vanillin, phenol, 2,4 bis(1,1-dimethyl ethyl, 2 pentadecanone, n-hexadecanoic). palmitic acid .According to the literature, 4 hydroxy-3 methoxy vanillin and palmitic acid were reported to have antimicrobial activity.
PERBANDINGAN PREFERENSI MASYARAKAT TERHADAP OBAT TRADISIONAL DAN OBAT SINTETIK DI APOTEK QUALITY KOTA BEKASI TAHUN 2019 dharma yanti; Nunung Nurhayati
Jurnal Ayurveda Medistra Vol 4 No 1 (2022): Jurnal Ayurveda Medistra
Publisher : STIKes Medistra Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51690/medistra-jurnal123.v4i1.55

Abstract

Drugs based on their active ingredients are divided into two, namely traditional drugs (derived from natural ingredients) and synthetic drugs (derived from chemicals). This study aims to compare the factors that influence people's preferences between choosing traditional and synthetic drugs at Apotek Quality, Jatibening in the city of Bekasi. The design of this research is non-experimental observation with a comparative approach. The research was conducted in Decembre 2019 for 3 weeks at Apotek Quality, Jatibening. The population in this study were all people who visited and or bought drugs at the Quality Pharmacy, Jatibening who were adults (> 18 years). The sampling technique used is the Incidental Sampling technique. Collecting data using direct interviews with the help of a questionnaire instrument, the data is then processed with Microsoft Excel. The results of this study indicate that the preference for traditional medicine is 55% and for synthetic medicine is 45%. Significant preference factors for traditional medicine are economic factors and psychological factors, while and synthetic drugs are dominated by psychological factors, this conclusion is drawn from a Likert scale questionnaire about the use of traditional and modern medicines. Characteristics of respondents related to drug preferences analyzed using the Chi Square method are: age, complaints of illness, occupation, sources of information about drugs and economic status. Characteristics of respondents that are not related to drug preference are: ethnicity, gender, marital status and education level
FORMULASI DAN UJI FAKTOR PELINDUNG SURYA SEDIAAN GEL EKSTRAK ETANOL 70% BUNGA KECOMBRANG (Etlingera elatior) dharma yanti
Jurnal Ayurveda Medistra Vol 4 No 2 (2023): Jurnal Ayurveda Medistra
Publisher : STIKes Medistra Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51690/medistra-jurnal123.v4i1.64

Abstract

Abstrak Ekstrak bunga kecombrang (Etlingera elatior) mengandung senyawa fenolik dan flavonoid yang mempunyai potensi sebagai pelindung surya karena mampu menyerap sinar UV A dan UV B. Paparan sinar UV diketahui dapat menimbulkan efek negatif pada kulit namun dapat diatasi melalui penggunaan sediaan pelindung surya. Penelitian ini bertujuan untuk mengetahui pengaruh bunga kecombrang (Etlingera elatior) terhadap formulasi sediaan gel serta nilai faktor pelindung surya sediaan gel. Sediaan dibuat sebanyak 4 formula dengan variasi konsentrasi ekstrak. Evaluasi sediaan gel meliputi uji organoleptis, uji homogenitas, uji pH, uji daya sebar, uji daya lekat, uji viskositas dan sifat alir serta uji pemisahan fase. Penentuan nilai FPS sediaan gel dilakukan dengan metode spektrofotometri. Hasil evaluasi sediaan gel menunjukkan bahwa konsentrasi bunga kecombrang (Etlingera elatior) dapat mempengaruhi keempat formula sediaan gel dan memenuhi persyaratan yang ditentukan. Hasil penentuan nilai FPS menunjukkan bahwa F1 memiliki nilai FPS 0,61 dan tidak termasuk kategori proteksi. Hal yang berbeda pada sediaan F2, F3 dan F4 menunjukkan bahwa ketiga formula masuk ke dalam kategori proteksi minimal. Uji analisis statistik dengan menggunakan One Way ANOVA dan dilanjutkan Uji Tukey HSD menunjukkan nilai p 0,000 < 0,05 sehingga menunjukkan bahwa terdapat perbedaan bermakna pada keempat formula. Berdasarkan hasil disimpulkan bahwa bunga kecombrang (Etlingera elatior) dapat mempengaruhi formulasi sediaan gel dan juga mempengaruhi nilai FPS pada sediaan gel. . Kata kunci: bunga kecombrang (Etlingera elatior), faktor pelindung surya, gel.
Co-Authors Nunung Nurhayati