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All Journal Jurnal Buana Farma
Faizal Hermanto
Fakultas Farmasi, Universitas Jenderal Achmad Yani, Cimahi, Indonesia
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology

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PENILAIAN RASIONALITAS PENGGUNAAN ANTIBIOTIK PADA PASIEN USIA 1-5 TAHUN DENGAN INFEKSI SALURAN PERNAPASAN AKUT (ISPA) DI PUSKESMAS CIMAHI TENGAH Sri Wahyuningsih; Faizal Hermanto; Andreanus A Soemardji; Riza Amelia; Yuliana Agustin
Jurnal Buana Farma Vol. 4 No. 2 (2024): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v4i2.1022

Abstract

Acute Respiratory Infection (ARI) is a disease that commonly occurs in children aged 1–5 years. Irrational use of antibiotics can cause bacterial resistance and unwanted side effects. This study aims to assess the rationality of antibiotic use in ISPA patients aged 1–5 years at the Central Cimahi Health Center in January–December 2022. The Central Cimahi Health Center conducted this descriptive study. This involves collecting retrospective prescription data from individuals aged 1–5 years throughout the period from January 2022 to December 2022. Data collection uses a saturated sampling method, where the total population is 526 prescriptions and prescriptions that do not meet the inclusion criteria and duplicates are 469 prescriptions, resulting in a total sample size of This research analyzed 56 recipes, both quantitatively and qualitatively. The evaluation of rationality includes the criteria for the right indication, the right drug, the right patient, and the right dose. The results show that the highest ARI characteristics are at the age of one year, namely 27% and the highest gender occurs in boys at 55%. The rationality of antibiotic use based on the criteria of right indication, right drug, right patient, and right dose shows a percentage of 100%. The Central Cimahi Community Health Center evaluates the rationality of antibiotic use in ISPA patients aged 1-5 years as rational
REVIEW ARTIKEL: PENINGKATAN KELARUTAN SENYAWA OBAT ANTIMALARIA MENGGUNAKAN METODE MODIFIKASI KO-KRISTAL Hasna; Faizal Hermanto
Jurnal Buana Farma Vol. 4 No. 3 (2024): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v4i3.1134

Abstract

Malaria is an infectious disease caused by the Plasmodium parasite that infects humans through the bite of female Anopheles mosquitoes. Most antimalarial drugs have limitations in terms of solubility. Drug solubility is a very important parameter that determines the effectiveness of the drug, with good drug solubility, the drug can achieve optimal bioavailability and pharmacological effects, based on this, efforts are needed to overcome these problems in order to provide effective and efficient therapy to patients using existing antimalarial drugs that have been modified in their physicochemical properties so that their solubility increases. The purpose of this study was to review various studies that used the co-crystal modification method to increase the solubility of antimalarial drug compounds. This study was designed using the Narrative Review method, article searches were carried out using two databases, namely Google Scholar and PubMed, with the keywords "Co-crystal" OR "Antimalaria". In this study, 7 articles were found that met the inclusion and exclusion criteria. The selected articles are articles that discuss antimalarial drugs (artesunate, artemisinin, pyrimethamine) developed by the co-crystal method which experienced a multi-fold increase in solubility compared to its pure preparation. The co-crystal method can be a solubility enhancing solution for antimalarial drugs that have low solubility in water, increasing the solubility of antimalarial drugs causes the bioavailability of the drug to increase, so that the drug can provide good therapeutic effects.
Co-Authors Andreanus A Soemardji Hasna Riza Amelia Sri Wahyuningsih Yuliana Agustin