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All Journal Jurnal Buana Farma Prosiding Seminar Nasional dan Call For Paper Kebidanan Universitas Ngudi Waluyo Jurnal Dedikasi Masyarakat
Hasna
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Biochemistry, Genetics & Molecular Biology Chemistry Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Social Sciences Other

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REVIEW ARTIKEL: PENINGKATAN KELARUTAN SENYAWA OBAT ANTIMALARIA MENGGUNAKAN METODE MODIFIKASI KO-KRISTAL Hasna; Faizal Hermanto
Jurnal Buana Farma Vol. 4 No. 3 (2024): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v4i3.1134

Abstract

Malaria is an infectious disease caused by the Plasmodium parasite that infects humans through the bite of female Anopheles mosquitoes. Most antimalarial drugs have limitations in terms of solubility. Drug solubility is a very important parameter that determines the effectiveness of the drug, with good drug solubility, the drug can achieve optimal bioavailability and pharmacological effects, based on this, efforts are needed to overcome these problems in order to provide effective and efficient therapy to patients using existing antimalarial drugs that have been modified in their physicochemical properties so that their solubility increases. The purpose of this study was to review various studies that used the co-crystal modification method to increase the solubility of antimalarial drug compounds. This study was designed using the Narrative Review method, article searches were carried out using two databases, namely Google Scholar and PubMed, with the keywords "Co-crystal" OR "Antimalaria". In this study, 7 articles were found that met the inclusion and exclusion criteria. The selected articles are articles that discuss antimalarial drugs (artesunate, artemisinin, pyrimethamine) developed by the co-crystal method which experienced a multi-fold increase in solubility compared to its pure preparation. The co-crystal method can be a solubility enhancing solution for antimalarial drugs that have low solubility in water, increasing the solubility of antimalarial drugs causes the bioavailability of the drug to increase, so that the drug can provide good therapeutic effects.
Literatur Review Faktor yang Berhubungan dengan Kejadian Preeklampsia pada Ibu Bersalin Hasna; Selviana, Riska; Anggraeni, Rini; Donela, Ardenia; Gresloan, Anny; Wahyuni, Sri; Pereira Doro, Noviana; Kartika Sari
Prosiding Seminar Nasional dan CFP Kebidanan Universitas Ngudi Waluyo Vol. 3 No. 1 (2024): Prosiding Seminar Nasional dan Call for Paper Kebidanan Universitas Ngudi Waluy
Publisher : Universitas Ngudi Waluyo

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Preeclampsia is a syndrome characterized by increased blood pressure and proteinuria that appears in the second trimester of pregnancy. This preeclampsia will usually recover in the postnatal period. Preeclampsia can occur antenatally, intranatally, postnatally. Mothers who experience hypertension due to pregnancy range from 10%, 3-4% of them have preeclampsia, 5% have hypertension and 1-2% have chronic hypertension. The highest cause of maternal and fetal mortality is due to preeclampsia. (Sari et al., 2021) Risk factors that can increase the incidence of preeclampsia are parity, extreme age and disease history. Preeclampsia is a complication of pregnancy that can result in an increase in AKI and AKB. Early prediction and screening of risk factors, especially age and parity, are recommended to prevent complications from continuing and improve maternal and fetal well-being. (Sartika et al., 2019).   Abstrak Preeklampsia adalah sindrom yang ditandai dengan peningkatan tekanan darah dan proteinuria yang muncul pada trimester kedua kehamilan. Preeklampsia ini biasanya akan pulih diperiode postnatal. Preeklampsia bisa terjadi pada antenatal, intranatal, postnatal. Ibu yang mengalami hipertensi akibat kehamilan berkisar 10%, 3 – 4 % diantaranya mengalami preeklampsia, 5 % mengalami hipertensi dan 1 – 2 % mengalami hipertesi kronik. Penyebab tertinggi angka kematian ibu dan janin adalah disebabkan akrena Preekampsia. (Sari et al., 2021). Faktor risiko yang dapat meningkatkan insiden preeklampsia ialah paritas, usia yang ekstrim dan riwayat penyakit. Preeklampsia termasuk penyulit kehamilan yang bisa berakibat peningkatan AKI dan AKB. Prediksi dan screening awal pada faktor resiko terutama usia dan paritas direkomendasikan untuk pencegahan komplikasi berlanjut dan meningkatkan kesejahteraan ibu danjanin.(Sartika et al., 2019).
Pelatihan dan pemberdayaan masyarakat dalam pembuatan Virgin Coconut Oil (VCO) Sultan Hazanuddin; Saskia Aulia Ashar; Muhammad Aidil Ramadhan Syafruddin; Nur Abidah; Muhammad Adrian; Muh Ainul Fitrah; Andi Dihya; Baiduri Musfira Saad; Idawati; Hasna
Jurnal Dedikasi Masyarakat Vol. 7 No. 2 (2024): Jurnal Dedikasi Masyarakat
Publisher : P3HKI - Universitas Muhammadiyah Parepare

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31850/jdm.v7i2.3149

Abstract

Watang Bacukiki Village, Parepare, is rich in coconut trees. However, society has not fully utilized its economic potential and health benefits. This is caused by a lack of knowledge and skills in processing old coconuts and the perception that the process is complicated and requires high costs. Through instruction and mentoring, this service project seeks to improve the community's understanding of and proficiency in the conversion of aged coconuts into virgin coconut oil (VCO). The method used is a participatory and educational approach using lecture, discussion, demonstration, and mentoring techniques. The learning media used are handouts and videos. The community was very enthusiastic and knowledgeable about the principles and procedures involved in creating VCO. Additionally, the community now has more options to improve welfare and income thanks to this training. The community's knowledge and proficiency in turning old coconuts into VCO has increased as a result of this service project, which has also created new potential to improve welfare and revenue.
Co-Authors Andi Dihya Baiduri Musfira Saad Donela, Ardenia Faizal Hermanto Gresloan, Anny Idawati Kartika Sari Muh Ainul Fitrah Muhammad Adrian Muhammad Aidil Ramadhan Syafruddin Nur Abidah Pereira Doro, Noviana Rini Anggraeni Saskia Aulia Ashar Selviana, Riska Sri Wahyuni Sultan Hazanuddin