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All Journal As-syifaa Jurnal Farmasi JURNAL ILMU KEFARMASIAN INDONESIA
Muldiyana, Tya
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Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology

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Efek Ramuan Tradisional Kaliputih terhadap Kadar Glukosa Darah Puasa, SOD, HbA1c, dan Histopatologi Pankreas pada Tikus Diabetes yang Diinduksi Streptozotocin) Kusumo, Djati Wulan; Efendi, Yuli Nurullaili; Kintoko, Kintoko; Yuliana, Tri Puspita; Waznah, Urmatul; Muldiyana, Tya; Pulhehe, Hasni
JURNAL ILMU KEFARMASIAN INDONESIA Vol 21 No 1 (2023): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v21i1.1229

Abstract

Prevention of DM by controlling sugar and lipid levels is the main therapy. The traditional medicine diabetes herb from Kaliputih Batur, Banjarnegara, Central Java consists of 11 kinds of medicinal plants that are empirically proven to be efficacious for diabetes mellitus. The potion is prepared by the infundation method. Three control groups (normal, positive, and negative) and three test groups with different doses (18, 36, and 54 mL/kg BW) that had previously been induced by streptozotocin were created using Sprague Dawley (SD) albino rats. Using HE staining, observations were obtained on fasting blood glucose (FBG), superoxide dismutase (SOD), HbA1c, and pancreatic organs. At doses of 36 and 54 mL/kg bw, results analysis of biochemical parameters of FBG levels revealed a substantial decline (P<0.05). At all dosages of the herb, there was a significant change in SOD activity (P<0.05), and at a dose of 18 mL/kg BW compared to negative control, there was a significant difference in HbA1c levels (P<0.05). HE staining results revealed no distinctpathological alterations in pancreatic organ at the test dose compared to negative control with necrosis in the Langerhans insula. Herbal medicine for diabetes traditional medicine from Kaliputih Batur, Banjarnegara, Central Java has decreased blood glucose.
PENGARUH SUHU PENYIMPANAN TERHADAP SIFAT FISIK TABLET EFFERVESCENT EKSTRAK KULIT BUAH NAGA MERAH (Hylocereus polyrhizus) DAN BUAH LEMON (Citrus limon L.) Zafira, Areta Thea; Muldiyana, Tya; Santoso, Joko
As-Syifaa Jurnal Farmasi Vol 15, No 2 (2023): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jifa.v15i2.1067

Abstract

Effervescent tablet is a dosage form that can produce bubbles originating from an acid and base reaction that forms a gas. The reaction between acids and bases in effervescent tablets is very sensitive to temperature if stored continuously. So that testing for drug stability is very important in evaluating drugs, one of which is by knowing the effect of temperature on drug stability, especially in the form of effervescent tablets. This study aims to determine the effect of storage temperature on the physical properties of effervescent tablets made from red dragon fruit peel extract (Hylocereus polyrhizus) combined with lemon fruit powder (Citrus limon L.). The research method was carried out by storing effervescent tablets at cold temperature (±120C), room temperature (±250C), and warm temperature (±400C). And observed for 1 month with testing every 1 week. The results of this study are storage temperature can affect the physical properties of effervescent tablets made from red dragon fruit peel extract (Hylocereus polyrhizus) with a combination of lemon fruit powder (Citrus limon L.). The best temperature is cold temperature around 120C because at that temperature the acid and base reactions in effervescent tablets are not excessive which results in effervescent tablets still in a stable condition
Co-Authors Joko Santoso Kintoko Kintoko Kusumo, Djati Wulan Pulhehe, Hasni Tri Puspita Yuliana Waznah, Urmatul Yuli Nurullaili Efendi, Yuli Nurullaili Zafira, Areta Thea