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All Journal Homeostasis: Jurnal Mahasiswa Pendidikan Dokter
Hendriyono, Fransiskus Xaverius
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Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Public Health

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Journal : Homeostasis: Jurnal Mahasiswa Pendidikan Dokter

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PERBEDAAN KADAR UREUM DAN KREATININ PADA PREEKLAMPSIA DAN PREEKLAMPSIA BERAT Annisa, Haima; Yuseran, Hariadi; Hendriyono, Fransiskus Xaverius; Abimanyu, Bambang; Devi, Wivina Riza
Homeostasis Vol 7, No 1 (2024)
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/ht.v7i1.12379

Abstract

Abstract: Preeclampsia is pregnancy disorder (>20 weeks) characterized by hypertension with or without proteinuria. Failure trophoblast invasion in preeclampsia results impaired spiral artery remodeling, hypoxia, placental ischemia, endothelial dysfunction and kidney dysfunction. Kidney dysfunction cause urea and creatinine increase. This research aims determine the difference in urea and creatinine of preeclampsia versus severe preeclampsia at RSUD Ulin Banjarmasin 2020-2022. Analytical observational, retrospective cross-sectional. There were 60 preeclampsia and severe preeclampsia subjects at RSUD Ulin 2020-2022 according inclusion and exclusion criteria, non-probability sampling. Research results for median preeclampsia urea 13.0 mg/dL, minimum value 5.0 mg/dL, maximum value 75.0 mg/dL and median severe preeclampsia 30 mg/dL, minimum value 9.0 mg/dL, maximum value 100 mg/dL. Median preeclampsia creatinine 0.6 mg/dL, minimum value 0.14, maximum value 1.51 mg/dL and mean severe preeclampsia 1.0 mg/dL, standard deviation 0.41 mg/dL. There is significant difference in urea and creatinine in preeclampsia and severe preeclampsia, p=0.000 and p=0.001. Keywords: preeclampsia, severe preeclampsia, ureum, creatinine, RSUD Ulin Banjarmasin. Abstrak: Preeklampsia merupakan kelainan kehamilan (>20 minggu) ditandai hipertensi dengan atau tanpa proteinuria. Gagalnya invasi trofoblas pada preeklampsia mengakibatkan gangguan remodeling arteri spiralis, hipoksia, iskemia plasenta, disfungsi endotel dan berakhir pada disfungsi ginjal. Gangguan ginjal menyebabkan ureum dan kreatinin meningkat. Tujuan penelitian mengetahui perbedaan ureum dan kreatinin preeklampsia terhadap preeklampsia berat di RSUD Ulin Banjarmasin 2020-2022. Metode observasional analitik studi cross sectional retrospektif. Terdapat 60 subjek preeklampsia dan preeklampsia berat di RSUD Ulin Banjarmasin 2020-2022 sesuai kriteria inklusi dan eksklusi, teknik non-probability sampling. Hasil penelitian ureum preeklampsia median 13,0 mg/dL, nilai minimum 5,0 mg/dL, nilai maksimum 75,0 mg/dL dan preeklampsia berat median 30 mg/dL, nilai minimum 9,0 mg/dL, nilai maksimum 100 mg/dL. Kreatinin preeklampsia median 0,6 mg/dL, nilai minimum 0,14, nilai maksimum 1,51 mg/dL dan preeklampsia berat rerata 1,0 mg/dL, simpang baku 0,41 mg/dL. Kesimpulan: Terdapat perbedaan bermakna ureum dan kreatinin pada preeklampsia dan preeklampsia berat, nilai p=0,000 dan p=0,001. Kata-kata kunci: preeklampsia, preeklampsia berat, ureum, kreatinin, RSUD Ulin Banjarmasin
PERBEDAAN AKTIVITAS SGOT, SGPT DAN LDH PADA PREEKLAMPSIA DAN PREEKLAMPSIA BERAT Amelia, Fakhrina; Yuseran, Hariadi; Hendriyono, Fransiskus Xaverius; Abimanyu, Bambang; Devi, Wivina Riza
Homeostasis Vol 7, No 1 (2024)
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/ht.v7i1.12376

Abstract

Abstract: Preeclampsia is characterized by hypertension and proteinuria at gestational age >20 weeks. Preeclampsia occurs when endothelial dysfunction triggers organ damage, one of which is the liver. Cellular damage in the liver causes an increase in SGOT, SGPT and LDH. The research aims to determine whether there are differences in SGOT, SGPT and LDH activity in pregnant women with preeclampsia and severe preeclampsia. This type of research is an analytical observational, retrospective cross-sectional study. There were 60 subjects who met the inclusion criteria. Preeclampsia SGOT, SGPT and LDH activity had a median of 22 units/L, 12 units/L and 429 units/L, minimum values of 13 units/L, 3 units/L and 37 units/L, maximum values of 55 units/L, 53 units /L and 989 units/L. SGOT, SGPT and LDH activity in severe preeclampsia had a median of 61 units/L, 40 units/L and 811 units/L, minimum values of 41 units/L, 15 units/L and 402 units/L, maximum values of 1161 units/L, 977 units/L and 1756 units/L. Conclusion: There was a significant difference in SGOT, SGPT and LDH activity in preeclampsia and severe preeclampsia (p=0.000). Keywords: preeklampsia, severe preeklampsia, Serum Glutamic Oxaloacetic Transaminase, Serum Glutamic Pyruvic Transaminase, Lactate Dehydrogenase Abstrak: Preeklampsia ditandai hipertensi dan proteinuria pada usia kehamilan >20 minggu. Preeklampsia terjadi disfungsi endotel memicu terjadinya kerusakan organ salah satunya organ hati. Kerusakan seluler di hati menyebabkan peningkatan SGOT, SGPT dan LDH. Penelitian bertujuan mengetahui apakah terdapat perbedaan aktivitas SGOT, SGPT dan LDH pada ibu hamil preeklampsia dan preeklampsia berat. Jenis penelitian observasional analitik, studi cross sectional retrospektif. Didapatkan 60 subjek yang sesuai kriteria inklusi. Aktivitas SGOT, SGPT dan LDH preeklampsia mempunyai median 22 unit/L, 12 unit/L dan 429 unit/L, nilai minimum 13 unit/L, 3 unit/L dan 37 unit/L, nilai maksimum 55 unit/L, 53 unit/L dan 989 unit/L. Aktivitas SGOT, SGPT dan LDH preeklampsia berat mempunyai median 61 unit/L, 40 unit/L dan 811 unit/L, nilai minimum 41 unit/L, 15 unit/L dan 402 unit/L, nilai maksimum 1161 unit/L, 977 unit/L dan 1756 unit/L. Kesimpulan : didapatkan perbedaan bermakna aktivitas SGOT, SGPT dan LDH pada preeklampsia dan preeklampsia berat (p=0,000). Kata-kata kunci: preeklampsia, preeklampsia berat, Serum Glutamic Oxaloacetic Transaminase, Serum Glutamic Pyruvic Transaminase, Laktat Dehidrogenase
PERBEDAAN KADAR FERITIN PADA IBU HAMIL DENGAN COVID-19 TANPA DAN DISERTAI PREEKLAMPSIA Penelitian di RSUD Ulin Banjarmasin Periode Maret 2020- Periode Maret 2020-Februari 2022 Rahmatullah, Muhammad Ikhsan; Armanza, Ferry; Hendriyono, Fransiskus Xaverius; Aditya, Renny; Rahmiati, Rahmiati
Homeostasis Vol 6, No 3 (2023)
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/ht.v6i3.11459

Abstract

COVID-19 is an infectious disease which become a pandemic worldwide. Pregnant women are a vulnerable group infected with COVID-19. Ferritin is a marker of increased inflammation associated with the severity of COVID-19. Pregnant women with COVID-19 have a higher mortality than pregnant women without COVID-19. Low ferritin levels during 28-30 weeks of gestation are associated with a low incidence of preeclampsia. This study aims to determine whether there are significant feritin level difference in pregnant women with COVID-19 without and with preeclampsia. This type of research is analytic observational using a cross-sectional study design with retrospective data collection. The results of the study obtained 603 subjects, but only 63 subjects met the inclusion criteria. Pregnant women with COVID-19 without preeclampsia as 36 subjects were randomized thus obtained 27 subjects were pregnant women with COVID-19 without preeclampsia and 27 subjects were pregnant women with COVID-19 accompanied by preeclampsia. Pregnant women with COVID-19 without preeclampsia had a median 66 ng/mL with a minimum value 1 ng/mL and a maximum value 951 ng/mL and pregnant women with COVID-19 accompanied by preeclampsia had a median 55 ng/mL with a minimum value 2 ng/mL and a maximum value 1.112 ng/mL. The conclusion of this study was that there was no significant feritin level difference in pregnant women with COVID-19 without and with preeclampsia with p=0.924.
PERBEDAAN JUMLAH TROMBOSIT DAN PLR PADA PREEKLAMPSIA DAN PREEKLAMPSIA BERAT Dharagita, Putu Galuh; Yuseran, Hariadi; Hendriyono, Fransiskus Xaverius; Abimanyu, Bambang; Rosida, Azma
Homeostasis Vol 7, No 1 (2024)
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/ht.v7i1.12403

Abstract

Abstract: Preeclampsia is hypertension in pregnancy >20 weeks with ≥140/90 mmHg and proteinuria. Preeclampsia when trophoblast invasion fails, causing ischemia, damage to placental endothelium that triggers platelet aggregation. Excessive platelet activity reduces systemic platelet counts. The PLR describes platelet to lymphocyte ratio. Placental ischemia causing chronic inflammation. The general objective determined the difference platelet count and PLR in preeclampsia and severe preeclampsia at RSUD Ulin Banjarmasin. This research is observational analytical, cross sectional, non-probability sampling techniques. The results is 70 subjects with preeclampsia and severe preeclampsia according the inclusion criteria. It was found the mean platelet in preeclampsia 294.82 ± 97.65 thousand/µL and severe preeclampsia 231.80 ± 75.99 thousand/µL. The mean PLR in preeclampsia 176.76 ± 79. The median PLR for severe pre-eclampsia is 74.92, the minimum value 23.16, the maximum value 195.56. Conclusion: There were significant differences in platelet count and PLR in preeclampsia and severe preeclampsia (p=0.004; p=0.000). Keywords: Preeclampsia, severe Preeclampsia, Trombosit, PLR, Pregnant woman.  Abstrak: Preeklampsia adalah hipertensi dalam kehamilan (>20 minggu) dengan tekanan darah ≥140/90 mmHg dan disertai proteinuria. Preeklampsia ketika invasi trofoblas ke plasenta gagal, menyebabkan iskemia dan kerusakan endotel plasenta yang memicu agregasi trombosit. Aktivitas trombosit berlebihan menurunkan jumlah trombosit di sistemik. Jumlah PLR menjelaskan rasio trombosit dan limfosit absolut. Iskemia plasenta menghasilakan ketidakseimbangan fungsi kekebalan menyebabkan peradangan kronis. Tujuan umum mengetahui perbedaan jumlah trombosit dan PLR pada preeklampsia dan preeklampsia berat di RSUD Ulin Banjarmasin. Penelitian ini observasional analitik dengan cross sectional menggunakan teknik non-probability sampling. Hasil penelitian didapatkan 70 subjek dengan preeklampsia dan preeklampsia berat sesuai kriteria inklusi dan ekslusi. Didapatkan rerata jumlah trombosit pada preeklampsia 294,82±97,65 ribu/µL dan preeklampsia berat 231,80±75,99 ribu/µL. Rerata jumlah PLR pada preeklampsia 176,76±79. PLR preeklampsia berat median 74,92, nilai minimum 23,16 dan nilai maksimum 195,56. Kesimpulan: Didapatkan perbedaan bermakna jumlah trombosit dan PLR pada preeklampsia dan preeklampsia berat (p=0,004;p=0,000). Kata-kata kunci: Preeklampsia, Preeklampsia berat, Trombosit, PLR, Ibu hamil.
PERBEDAAN HEMATOKRIT MCV DAN MCHC PADA PREEKLAMPSIA DAN PREEKLAMPSIA BERAT Asie, Gracia Chika Medylona Eka; Yuseran, Hariadi; Hendriyono, Fransiskus Xaverius; Abimanyu, Bambang; Rosida, Azma
Homeostasis Vol 7, No 1 (2024)
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/ht.v7i1.12378

Abstract

Abstract: Preeclampsia is a condition of hypertension and proteinuria at gestational age >20 weeks. Preeclampsia causes endothelial dysfunction resulting in plasma extravasation and hemoconcentration, characterized by an increase in hematocrit. Erythrocytes swell, causing an increase in MCV and a decrease in MCHC. The aim of the research was to determine the differences between hematocrit, MCV and MCHC in preeclampsia versus severe preeclampsia at Ulin Hospital, Banjarmasin. Analytical observational research method, retrospective cross-sectional research design. Purposive sampling for the 2020-2022 period, using 60 subjects according to inclusion and exclusion criteria. Analysis used unpaired T test and Mann Whitney. The results showed that the mean hematocrit for preeclampsia was 36.05 ± 3.64% and severe preeclampsia was 38.89 ± 2.83%. The median MCV for preeclampsia was 84.25 fL, the minimum value was 67.40 fL and the maximum value was 92.20 fL and the median for severe preeclampsia was 88.10 fL, the minimum value was 77.70 fL and the maximum value was 94.20 fL. The mean MCHC for preeclampsia was 33.53±1.38 g/dl and severe preeclampsia 34.16±0.88 g/dl. It can be concluded that there is a significant difference between hematocrit, MCV and MCHC in pregnant women with preeclampsia and severe preeclampsia (p<0.05). Keywords: preeclampsia, severe preeclampsia, hematocrit, MCV, MCHC Abstrak: Preeklampsia merupakan kondisi adanya hipertensi dan proteinuria pada usia kehamilan >20 minggu. Preeklampsia menyebabkan disfungsi endotel sehingga terjadi ekstravasasi plasma dan terjadi hemokonsentrasi, ditandai peningkatan hematokrit. Eritrosit membengkak, menyebabkan peningkatan MCV dan penurunan MCHC. Tujuan penelitian mengetahui perbedaan hematokrit, MCV dan MCHC pada preeklampsia terhadap preeklampsia berat di RSUD Ulin Banjarmasin. Metode penelitian observasional analitik, desain penelitian cross sectional retrospektif. Pengambilan sampel purposive sampling periode 2020-2022, menggunakan 60 subjek sesuai kriteria inklusi dan eksklusi. Analisis menggunakan uji t-tidak berpasangan dan Mann Whitney. Hasil penelitian menunjukan rerata hematokrit preeklampsia 36,05±3,64% dan preeklampsia berat 38,89±2,83%. Median MCV preeklampsia 84,25 fL, nilai minimum 67,40 fL dan nilai maksimum 92,20 fL serta median preeklampsia berat 88,10 fL, nilai minimum 77,70 fL dan nilai maksimum 94,20 fL. Rerata MCHC preeklampsia 33,53±1,38 g/dl dan preeklampsia berat 34,16±0,88 g/dl. Dapat disimpulkan adanya perbedaan bermakna antara hematokrit, MCV dan MCHC pada ibu hamil dengan preeklampsia dan preeklampsia berat (p < 0,05). Kata-kata kunci: preeklampsia, preeklampsia berat, hematokrit, MCV, MCHC
PERBEDAAN RASIO NEUTROFIL-LIMFOSIT DAN C-REACTIVE PROTEIN PADA IBU HAMIL DENGAN COVID-19 TANPA DAN DISERTAI PREEKLAMPSIA Penelitian di RSUD Ulin Banjarmasin Periode Maret 2020 - Periode Maret 2020-Februari 2022 Qaedi, Muhammad Bari Nur; Armanza, Ferry; Hendriyono, Fransiskus Xaverius; Aditya, Renny; Rahmiati, Rahmiati
Homeostasis Vol 6, No 3 (2023)
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/ht.v6i3.11456

Abstract

COVID-19 is an infectious disease caused by the SARS-CoV-2 virus. Pregnant women are vulnerable to COVID-19. Preeclampsia is a complication in pregnant women characterized by hypertension at > 20 weeks of gestation and proteinuria. The Neutrophils Lymphocyte Ratio and C-Reactive Protein is a marker of inflammation related to disease severity. Elevated NLR and CRP are associated with COVID-19 and preeclampsia. The study aims to determine whether there are significant differences in NLR values or CRP levels for pregnant women with COVID-19 without and with preeclampsia. This type of research is analytic observational using a retrospective cross-sectional study. The results of the study were 603 subjects, 70 subjects met the inclusion criteria. Subjects of pregnant women with COVID-19 without preeclampsia were randomized, obtained 30 subjects of pregnant women with COVID-19 without preeclampsia and 30 subjects accompanied by preeclampsia. The NLR value of pregnant women with COVID-19 without preeclampsia had a median of 5.57, a minimum value of 1.90 and a maximum value of 30.38. Those accompanied by preeclampsia had a median of 5.13, a minimum value of 2.04 and a maximum value of 18.10. CRP levels of pregnant women with COVID-19 without preeclampsia had a median of 45.2 mg/L, a minimum value of 2.0 mg/L and a maximum value of 240.0 mg/L. Those accompanied by preeclampsia had a median of 50.4 mg/L, a minimum value of 2.6 mg/L and a maximum value of 318.1 mg/L. Conclusion: there was no significant difference in NLR values or CRP levels in pregnant women with COVID-19 without and with preeclampsia (p=0.631, p=0.478).
Co-Authors Abimanyu, Bambang Amelia, Fakhrina Annisa, Haima Asie, Gracia Chika Medylona Eka Azma Rosida, Azma Devi, Wivina Riza Dharagita, Putu Galuh Ferry Armanza, Ferry Qaedi, Muhammad Bari Nur Rahmatullah, Muhammad Ikhsan Rahmiati Rahmiati Renny Aditya Yuseran, Hariadi