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Fiska Rosita
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Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Korelasi Kadar Serum Nitric Oxide (NO) dengan Tipe dan Derajat Keparahan Psoriasis Fiska Rosita; Bobby Febrianto; Ambar Aliwardani; Putti Fatiharani; Wibisono Nugraha; Muhammad Eko Irawanto; Nurrachmat Mulianto
MEDICINUS Vol. 34 No. 2 (2021): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (103.767 KB) | DOI: 10.56951/medicinus.v34i2.61

Abstract

Psoriasis is a chronic, immune-mediated disorder that results from a polygenic predisposition. Nitric oxide (NO) has been considered as important factors in the pathogenesis of psoriasis. This study aims to determine the correlation of serum NO levels with the type and severity of psoriasis. This cross-sectional study was conducted from May to September 2018. Difference in the average of serum NO levels in psoriasis patients with control groups is analyzed using t-test. The Spearman correlation test was used to see the correlation of serum NO levels with type and severity of psoriasis measured by Psoriasis Area and Severity Index (PASI) score. There was significant difference between serum NO level in the control group compared to the group of psoriasis patients (p=0.037). Patient with generalized pustular psoriasis has the highest mean of NO level (59.07 µmol/L). There was no significant correlation between serum NO level with type (r=0.008, p=0.9710 and severity (r=0.157, p=0.486) of psoriasis. Nitric oxide levels are elevated in psoriasis patients, which indicate that oxidative stress plays an important role in the etiopathogenesis of psoriasis.
Tingkat Perbedaan Serum Nitric Oxide terhadap Derajat Keparahan dan Durasi Psoriasis Ambar Aliwardani; Bobby Febrianto; Fiska Rosita; Putti Fatiharani Dewi; Muhammad Eko Irawanto
MEDICINUS Vol. 35 No. 1 (2022): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (87.306 KB) | DOI: 10.56951/medicinus.v35i1.84

Abstract

Psoriasis belongs to erythrosquamous dermatosis with uncertain etiology. Nitric oxide (NO) that acts as growth and differentiation regulator of keratinocytes is thought to play an important role in the pathogenesis of this disease. This study was aimed to determine the difference of nitric oxide serum level with the severity and duration of psoriasis patients. A cross-sectional study was conducted in 22 subjects with psoriasis vulgaris in the outpatient clinic of Dr. Moewardi Hospital Surakarta from May-September 2018 with 22 healthy individuals as control group. The severity of psoriasis was assessed using psoriasis area severity index (PASI), and serum NO is measured using Greiss method. Data then analysed using T-test and Kruskal Wallis tests (p<0.05). There was a significant difference in serum NO between the psoriasis patients and control group (p=0.020); there was no significant difference between serum NO patients and PASI score and duration of disease. It can be concluded that NO is an important factor in the inflammatory process in psoriasis, especially in active lesion.
Laporan Kasus Pyoderma Gangrenosum disertai Kandidiasis Kutis pada Wanita dengan Sindrom Metabolik Ambar Aliwardani; Fiska Rosita; Putti Fatiharani; Endra Yustin Ellistasari
MEDICINUS Vol. 35 No. 1 (2022): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (319.591 KB) | DOI: 10.56951/medicinus.v35i1.85

Abstract

Introduction: Pyoderma gangrenosum (PG) is a rare inflammatory disease characterized by sterile, predominantly neutrophilic infiltration of the skin and other organs. PG is found particularly in women aged between 40-60 years. Metabolic syndrome is reported to have a potential role to induce PG. Case: A 45-year-old woman came to Dr. Moewardi Hospital with chief complaints of ulcer in the chest and legs that was preceded by reddish fluid filled bump which then broke into painful wound. History of trauma, gastrointestinal, and joint pain was denied. Dermatological examination of anterior trunk region and inferior extremity showed erythematous patches with multiple ulcers with irregular border covered with hemorrhagic crusts and necrotic tissue. Pathergy test was negative. In the right and left axillary, inframammary and inguinal, there were hyperpigmented patches with scales and satellite lesions, KOH 10% examination obtained pseudohyphae and cell budding. The patient also has metabolic syndrome. Diagnosis of PG was made based on the presence of 2 major and 2 minor criteria. Patient was given intravenous methylprednisolone 93.75 mg/24 hours, analgesics, antibiotics, topical antifungals, debridement and breast reconstructive surgery after response to steroid therapy was seen. The patient was discharges from hospital with improvement. Discussion: Metabolic syndrome is considered to be a risk factor contributing to the development of systemic chronic inflammatory processes and has been described as one of the precipitating factors for PG and skin candidiasis. Management of metabolic syndrome as the known risk factor aims to minimize the recurrence of PG in the future.
Modalitas Terapi Striae Ambar Aliwardani; Putti Fatiharani Dewi; Fiska Rosita; Indah Julianto
MEDICINUS Vol. 36 No. 2 (2023): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/medicinus.v36i2.124

Abstract

Striae or strechmark is a form of benign skin lesion manifested as inflammatory streaks perpendicular to the direction of skin tension which has cosmetic morbidity and possesses risk of secondary infection in severe case. Various therapeutic modalities have been introduced, such as topical therapy, physical therapy using devices, lasers, and the latest is celullar therapy using platelet-rich plasma. Such varied treatment modalities are reported to have varied results.
Co-Authors Ambar Aliwardani Bobby Febrianto Endra Yustin Ellistasari Indah Julianto Muhammad Eko Irawanto Nurrachmat Mulianto Putti Fatiharani Putti Fatiharani Dewi Wibisono Nugraha