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Reti Anggraeni
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Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Pengaruh Astaxantine Oral terhadap Kadar Serum Tumor Necrosis Factor Alpha pada Pasien Akne Vulgaris-lores Reti Anggraeni; Niluh Widjayanti; Harijono Kariosentono; Indah Julianto; Endra Yustin; Muhammad Eko Irawanto; Prasetyadi Mawardi
MEDICINUS Vol. 33 No. 3 (2020): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (275.412 KB) | DOI: 10.56951/medicinus.v33i3.73

Abstract

Background: Acne vulgaris (AV) is chronic inflammatory disease affecting the pilosebaceous unit manifested as closed and open comedones, papules, pustules, and nodules. Treatment of AV generally involves more than one drug due to multifactorial pathogenesis. Objective: This study aims to determine the efficacy of 4 mg oral astaxanthin as an adjuvant AV therapy in decreasing serum level of inflammatory marker tumor necrosis factor alpha (TNF-α). Method: This is a double-blind randomized controlled trial. Subjects were 34 patients with mild and moderate AV (Global Acne Grading System/GAGS 1-30) that were treated with combination of tretinoin 0.025% and clindamycin phosphate 1.2%. Astaxanthin was added to the treatment group and lactulose as placebo was added to the control groups, given for 4 weeks. The pretest and posttest results in both groups were analyzed statistically using nonparametric test. Results: Decrease in TNF-α serum levels occurred in both groups but significant difference compared to baseline were only found in treatment group (p=0.015). There was no significant difference in the reduction of TNF-α levels between both groups (p=0.459). Conclusion: Although the results did not show a significant difference overall, but in the treatment group, astaxanthin can significantly lower TNF-α serum levels compared to baseline.
Terapi Probiotik pada Akne Vulgaris Reti Anggraeni; Arie Kusumawardani
MEDICINUS Vol. 34 No. 2 (2021): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (224.003 KB) | DOI: 10.56951/medicinus.v34i2.76

Abstract

Acne vulgaris (AV) is a skin chronic inflammatory disease that affects pilosebaceous unit and results in non-inflammatory abnormalities in the form of open comedones (blackhead) and closed comedones (whitehead) and also inflammatory lesions such as papules, pustules and nodules. Many factors contribute to the pathogenesis of AV including skin microbiomes like Propionibacterium acnes (P. acnes) and Malassezia spp. which is associated through its effect on sebum secretion, comedones formation and inflammatory response. Antibiotic therapy with the target of P. acnes has long been the mainstay of AV therapy where it can actually affect the composition of skin microbiomes. As antibiotic resistance increases, knowledge of skin microbiomes associated with AV becomes very relevant and important to be an alternative basis for AV alternative therapy.
Co-Authors Arie Kusumawardani Endra Yustin Harijono Kariosentono Indah Julianto Muhammad Eko Irawanto Niluh Widjayanti Prasetyadi Mawardi