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All Journal Indonesian Journal of Halal Research JIFI (Jurnal Ilmiah Farmasi Imelda)
Larasati, Rizky Dwi
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Religion Biochemistry, Genetics & Molecular Biology Environmental Science Medicine & Pharmacology Other

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REVIEW ARTIKEL PENGARUH VARIASI KOSOLVEN TERHADAP STABILITAS SIRUP PARACETAMOL Fatimi, Hana Anisa; Manurung, Devi Yanthre Sari; Larasati, Rizky Dwi; Ramadhana, Irma Hazira Awalinda; Putranti, Inneke Nurul Dwi; Kholifatuzzahroh; Shafwa, Mayra
JIFI (Jurnal Ilmiah Farmasi Imelda) Vol. 8 No. 1 (2024): Vol. 8 No. 1, September Tahun 2024
Publisher : Universitas Imelda Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52943/jifarmasi.v8i1.1767

Abstract

The syrup is made with the aim of increasing patient acceptance in taking medicine because it is convenient and practical when consumed. Paracetamol is classified as a drug that is rather difficult to dissolve in water with a water solubility of 1: 70 so that in the formulation of syrups it is necessary to assist the dissolution process with several methods such as cosolvention and the addition of surfactants. This review article aims to analyze the studies that have been conducted related to the effect of cosolvent variations on the stability of paracetamol syrup preparation formulations. Several tests were conducted to evaluate the preparation of paracetamol syrup, namely organoleptic test, content determination test, pH test, viscosity test, and specific gravity test. Data was obtained from relevant literature sources such as Google Scholar, ResearchgateNet and Science direct and obtained 10 journals that met the criteria. The use of different cosolvents in syrup will produce different physical values. Paracetamol syrup with PEG 400 and glycerin cosolvents had greater viscosity than paracetamol syrup with propylene glycol and Ryoto sugar ester cosolvents. Paracetamol syrup with PEG 400 and glycerin cosolvents had a greater specific gravity than paracetamol syrup with propylene glycol cosolvents and Ryoto sugar ester surfactant. Based on the results of a review of 10 journal articles, it appears that the use of different cosolvents in paracetamol syrup preparations can modify the preparation and affect the level of stability of the resulting syrup preparation.
Characterization of Banana Peel Pectin (Musa acuminata Colla) as a Potential Halal Pharmaceutical Excipient Tugon, Titian Daru Asmara; Larasati, Rizky Dwi; Adnan, Saepul; Sucimilawati, Eris; Agustiani, Fuji Sintya; Jaswir, Irwandi
Indonesian Journal of Halal Research Vol 5, No 1 (2023): February
Publisher : UIN Sunan Gunung Djati Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15575/ijhar.v5i1.21285

Abstract

Indonesian Halal Product Assurance Law No. 33 of 2014 states all products circulating in Indonesia must be halal-certified, including pharmaceuticals. Banana peel waste has the potential to produce pectin compounds as pharmaceutical excipients. This study is aimed at determining the characteristics of banana peel pectin as a potential halal pharmaceutical excipient. It has involved qualitative tests and established characteristics of extract pectin by organoleptic test, acidity (pH) test, solubility, equivalent weight, methoxyl concentration, galacturonic acid concentration, esterification degree, moisture content, and ash content. The yield of pectin produced was 17.19%. The qualitative test showed positive pectin, the characteristics of a white powder that is slightly ash, odorless, has a pH of 6.02, is soluble in water, insoluble in ethanol 96%, has an equivalent weight of 5,000 mg, methoxyl concentration of 2.6%, galacturonic acid concentration of 73.92%, esterification degree of 20.19%, moisture content of 7.139% and ash content of 1.6%. Based on the characterization results, banana peel pectin is, by pectin quality standards, a pharmaceutical excipient, especially as a raw material for manufacturing capsule shells, thickeners, and coating and gelling agents.
Co-Authors Adnan, Saepul Agustiani, Fuji Sintya Fatimi, Hana Anisa Jaswir, Irwandi Kholifatuzzahroh Manurung, Devi Yanthre Sari Putranti, Inneke Nurul Dwi Ramadhana, Irma Hazira Awalinda Shafwa, Mayra Sucimilawati, Eris Tugon, Titian Daru Asmara