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Yusnaidar
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Chemical Engineering, Chemistry & Bioengineering Chemistry Education

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Development of a Metacognition-Based E-Book Using 3D Pageflip to Enhance Polymer Chemistry Literacy in Coordination Polymerization Reactions Yusnaidar; Syahri, Wilda
Journal of The Indonesian Society of Integrated Chemistry Vol. 16 No. 1 (2024): Journal of The Indonesian Society of Integrated Chemistry
Publisher : Pendidikan Kimia FKIP Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/jisic.v16i1.29509

Abstract

The development of a metacognition-based e-book using 3D Pageflip on coordination polymerization reaction materials aims to enhance students' polymer chemistry literacy. The Polymer course in the Chemistry Education Study Program covers various polymerization reactions essential for students in today's educational era. Polymers, including plastics, Styrofoam, nylon, and others, are crucial materials in various aspects of life. Due to the abstract nature of this subject, theoretical explanations are challenging for students to understand. A metacognition-based e-book is expected to assist students in self-learning, increasing flexibility in understanding polymerization reaction materials. This study employs the ADDIE development model (Analysis, Design, Development, Implementation, and Evaluation) and produces an e-book containing text, animations, videos, and music. Validation by experts indicates that the e-book is excellent in terms of content and design. Implementation among students shows that this e-book is effective in enhancing the understanding of coordination polymerization reactions. Thus, the e-book is expected to facilitate learning and improve students' polymer chemistry literacy. Keyword:        Science literacy, polymer chemistry, polymerization reaction, coordination polymerization.
In Silico Study of Bioactive Compounds of Putat Leaf Extract (Planchonia valida) as Anti-Cancer Against the VEGFR2 Receptor Bela, Anisa; Dewi, Tribuana Tungga; Prabawa, Satria; Khatib, Alfi; Yusnaidar; Latief, Madyawati; Tarigan, Indra Lasmana
Journal of The Indonesian Society of Integrated Chemistry Vol. 16 No. 1 (2024): Journal of The Indonesian Society of Integrated Chemistry
Publisher : Pendidikan Kimia FKIP Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/jisic.v16i1.32049

Abstract

Cancer is the process of forming new tissue that is abnormal and malignant. Efforts to discover anti-cancer drug compounds continue to be made to minimize the toxic effects of chemotherapy, so it is necessary to look for other alternatives to treat cancer. This research aims to determine the anti-cancer activity of putat plant bioactive compounds through identification of receptor targets and interaction studies using the molecular docking method against the VEGFR2 (Vascular endothelial growth factor receptor-2) receptor. The results showed that in the test of eight putat plant bioactive compounds the best results were obtained for the compound 3-oxo-N-(1,3-thiazol-2-yl) butanamide with a binding free energy value of -9.86 kcal-mol-1 with an inhibition constant value of 1.47 Micromolar. The best docking result has an inhibition constant value that is higher than the native ligand and has a binding free energy that is almost close to the binding free energy of the native ligand with an inhibition constant value of 42.38 Micromolar and a binding free energy value of 10.06 kcal-mol-1. Therefore, the results of the docking of the bioactive compound 3-oxo-N-(1,3-thiazol-2-yl) butanamide with the VEGFR-2 receptor are considered capable of being an alternative as a candidate for anti-cancer drugs.
Co-Authors Alfi Khatib, Alfi Bela, Anisa Dewi, Tribuana Tungga Indra Lasmana Tarigan Madyawati Latief Prabawa, Satria Wilda Syahri