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All Journal Pharmaciana: Jurnal Kefarmasian Jurnal 'Aisyiyah Medika Jurnal Farmasi Sains dan Praktis Jurnal Pengabdian Pada Masyarakat
Shiyan, Shaum
Program Studi Farmasi, Fakultas Matematika Dan Ilmu Pengetahuan Alam, Universitas Sriwijaya, Indralaya, Indonesia
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Journal : Jurnal Farmasi Sains dan Praktis

 1 
AKTIVITAS ANTIDIABETES EKSTRAK ETANOLIK DAUN KOPI ROBUSTA (Coffea canephora) PADA TIKUS DIABETES TIPE 2 YANG DIBERI DIET LEMAK TINGGI DAN SUKROSA Shaum Shiyan; Herlina Herlina; Della Arsela; Elmiawati Latifa
Jurnal Farmasi Sains dan Praktis Vol 3 No 2 (2017)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v3i2.1730

Abstract

Daun kopi robusta (Coffea canephora) memiliki potensi sebagai agen antioksidan dan antidiabetes karena kandungan senyawa fenolik yang melimpah. Penelitian ini bertujuan untuk mengetahui potensi ekstrak etanolik daun kopi robusta (EEDK) terhadap penurunan kadar glukosa darah. Hewan uji dibagi menjadi kelompok normal, kontrol negatif (NaCMC 0,5%), kontrol positif (metformin 34,6 mg/200 gBB), dan tiga perlakuan (EEDK dosis 59, 118, dan 236 mg/kgBB). Pemodelan tikus diabetes dengan pemberian sukrosa dan diet lemak tinggi selama 85 hari. Ekstrak diberikan pada hari ke-86 sampai 100, kadar glukosa darah diukur hari 91; 96 dan 101. Penurunan kadar glukosa darah kelompok kontrol positif sebesar 69,26%. Kelompok perlakuan ekstrak berturut-turut 47,05%; 56,93% dan 72,48%. Ekstrak daun kopi robusta memiliki aktivitas sebagai antidiabetes dan tidak terdapat perbedaan dibandingkan metformin (p>0,05). Rata-rata nilai AUC96-101 yang paling rendah dan mempunyai persentase penurunan kadar glukosa darah yang paling besar ditunjukan oleh EEDK dosis 236 mg/kgBB. Nilai ED50 EEDK yaitu 126,90 mg/kg BB. Daun kopi robusta memiliki potensi sebagai agen antidiabetes.
EVALUATION OF RESPONSE CORELLATION USING CHEMOMETRICS ANALYSIS FOR PRE-OPTIMIZATION QUERCETIN – SELF EMULSION FORMULATION Shaum Shiyan; Jessica Nathasia; Galih Pratiwi
Jurnal Farmasi Sains dan Praktis Vol 8 No 2 (May-August 2022)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v8i2.6660

Abstract

The optimization approach using the simplex lattice design (SCD) has many advantages, including a minimized number of experiments and a good description of the interactions between components. However, modeling with the SCD approach has not evaluated between responses. Therefore, this study aims to apply chemometric analysis to evaluate the response from the optimization stage using the quercetin – self emulsion formulations (quercetin-SEFs) as a model. SEFs were prepared using grapeseed oil, croduret, and PEG 400. The evaluated responses included emulsification time and transmittance. Both responses were developed in endurance test by centrifugation method and stability test using freeze-thaw. Chemometric analysis on CA produced a dendrogram, while PCA produced score plots, loading plots, scree plots, and biplots. Emulsification time has a positive correlation with transmittance value. The quercetin-SEFs formula in SCD was classified into three groups based on the similarity of characters. Chemometric analysis was successfully applied in evaluating the response to the quercetin-SEFs optimization modeling.
Co-Authors Annisa Mutiara Bella Arsela, Della Bella, Annisa Mutiara Della Arsela Elmiawati Latifa Galih Pratiwi Galih Pratiwi Herlina . Herlina Herlina Herlina Herlina Indah Solihah Jessica Nathasia Laida Neti Mulyani Latifa, Elmiawati Mas Ayu Anggun Prasasty Mayang Tari Misirti Maulidia Anis Marketama Rianasari Puspita Rasyid Soilia Fertilita Suprayetno Suprayetno Viva Starlista Yudi Arina Yudi Arina Yudi Arina