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Formulasi Salep Ekstrak Buah Mengkudu (Morinda citrifolia L.) Kombinasi Zeolit Alam Lampung (Zal) Sebagai Penstabil Sediaan Antibakteri Staphylococcus aureus Laila Susanti; Lilik Koernia Wahidah; Pratika Viogenta
Jurnal Pharmascience Vol 7, No 1 (2020): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v7i1.8086

ABSTRAK Sediaan salep esktrak buah mengkudu telah terbukti sebagai antibakteri, namun esktrak tanaman pada umumnya sangat mudah terdegradasi oleh pH, cahaya dan suhu, oleh karena itu pemanfaatan Zeolit Alam Lampung (ZAL) dengan keistimewaan struktur morfologinya diharapkan mampu mempertahankan kestabilan sediaan salep hingga suhu tinggi. Penelitian ini bertujuan untuk mengetahui potensi ZAL sebagai penstabil sediaan salep dengan menghitung perubahan prosentase zona hambat bakteri pada sediaan salep sebelum dan sesudah dilakukan penyimpanan pada suhu 40oC. Penelitian ini meliputi tiga tahap utama yakni pertama formulasi salep ekstrak buah mengkudu kombinasi Zeolit Alam Lampung (ZAL) dengan variasi konsentrasi ekstrak 10%+ZAL, 15%+ZAL, 30%+ZAL, KZ (Kontrol Zeolit tanpa esktrak) dan KE (Kontrol Ekstrak tanpa zeolit) yang kemudian dilakukan evaluasi sediaan salep. Tahap kedua seluruh sampel dilakukan uji aktivitas antibakteri terhadap bakteri Staphylococcus aureus pada sediaan salep, dan tahap ketiga seluruh sampel disimpan pada suhu 40oC selama 24 jam, kemudian diuji aktivitas antibakteri kembali terhadap bakteri Staphylococcus aureus. Hasil penelitian menunjukkan bahwa seluruh sampel sebelum dilakukan penyimpanan pada suhu 40oC menunjukkan respon zona hambat bakteri yang kuat kecuali KZ. Setelah dilakukan penyimpanan pada suhu 40oC, terjadi penurunan zona hambat pada KE dan Ekstrak 10%+ZAL sebesar 100% dan 36,81%. Hal yang menarik terjadi pada Esktrak 15%+ZAL dan 30%+ZAL, yakni terjadi kenaikan zona hambat sebesar 35,20 % dan 31,32%. Hasil uji statistik menunjukkan nilai Asymp. Sig (0,016) < nilai p (0,01) maka H0 ditolak sehingga dilakukan uji lanjut Tukey yang menunjukkan terjadi perbedaan yang signifikan antar kelompok uji. Dari penjelasan tersebut maka dapat disimpulkan bahwa ZAL mampu meningkatkan kinerja sediaan salep ekstrak buah mengkudu terutama pada konsentrasi 15% dan 30% dalam menghambat bakteri Staphylococcus aureus sehingga sediaan salep esktrak buah mengkudu kombinasi ZAL dapat digunakan sebagai alternatif obat pengganti obat sintetik kimiawi. Kata kunci : Zeolit, Salep, M.citrifolia L, Staphylococcus aureus ABSTRACT Noni extract ointment has been proven to be antibacterial, but plant extracts are generally very easily degraded by pH, light and temperature, therefore the use of Lampung Natural Zeolite (ZAL) with its special morphological structure is expected to be able to maintain the stability of ointment preparations to high temperatures. This study aims to determine the potential of ZAL as a stabilizer for ointment preparations by calculating the change in the percentage of bacterial inhibition zones in ointment preparations before and after storage at 40oC. This study includes three main stages, namely the first formulation of noni extracts from Lampung Natural Zeolite extract (ZAL) with variations in extract concentration of 10% + ZAL, 15% + ZAL, 30% + ZAL, KZ (Zeolite control without extract) and KE (Control Extract without zeolite) which then evaluated the ointment preparation. The second stage of all samples was tested for antibacterial activity against Staphylococcus aureus bacteria in ointment preparations, and the third stage all samples were stored at 40oC for 24 hours, then tested for antibacterial activity against Staphylococcus aureus. The results showed that all samples before storage at 40oC showed a strong inhibitory zone response except KZ. After storage at 40oC, there was a decrease in inhibition zones at KE and Extract 10% + ZAL by 100% and 36.81%. An interesting thing happened at the Extract 15% + ZAL and 30% + ZAL, namely an increase in inhibition zones of 35.20% and 31.32%. Statistical test results indicate the Asymp value. Sig (0.016) >p value (0.01) then H0 is accepted, so Tukey's further tests show that there are significant differences between the test groups. From this explanation it can be concluded that ZAL can improve the performance of noni fruit extract ointment especially at concentrations of 15% and 30% in inhibiting Staphylococcus aureus bacteria so that the ZAL noni extract extract can be used as an alternative drug for chemical synthetic drugs. Keywords : Zeolite, Ointment, M.citrifolia L, Staphylococcus aureus

Aktivitas Antibakteri Ekstrak Akar Ceplukan (Physalis angulata L.) Terhadap Staphylococcus epidermidis dan Pseudomonas aeruginosa Pratika Viogenta; Lilik Koernia Wahidah; Ika Harum Saputri
JFL : Jurnal Farmasi Lampung Vol. 6 No. 2 (2017): JFL: Jurnal Farmasi Lampung
Publisher : Fakultas MIPA Universitas Tulang Bawang Lampung

Root ceplukan (Physalis angulata L.) is one of the medicinal plants that contain several active compounds that are antibacterial. This study aims to prove the antibacterial activity of root ceplukan extract againsts Staphylococcus epidermidis bacteria and Pseudomonas aeruginosa bacteria. Root ceplukan was extracted by maceration with ethanol 70%. Root root extracts of phytochemical screening include flavonoids, alkaloids and saponins. The ceplukan root extract was then tested against S. epidermidis and P. aeruginosa bacteria using wells method with concentrations of 20%, 40%, 60%, 80%, 100%, aquades as a negative control and amikacin as a positive control. Inhibitory zone diameter with each concentration for P. aeruginosa bacteria, among others, negative control = 0 mm, positive control = 21,623 mm, 100% = 16.9 mm, 80% = 15.05 mm, 60% = 13.703 mm, 40% = 12.02 mm, 20% = 12.02 mm and S. epidermidis bacteria have inhibitory zone at positive control of 21,623 mm. The results of this study showed that root extract ceplukan proved to have inhibition zone against bacteria P. aeruginosa at all concentrations but has no inhibition zone against S. epidermidis bacteria. Root ceplukan extract has a minimum inhibitory concentration of 14% and a minimum bacterisid concentration of 20%, against P. aeruginosa bacteria. The results of phytochemical analysis showed that root ceplukan positively contain flavonoids, alkaloids and saponins are suspected as antibacterial compounds. Keywords : Antibacterial, Staphylococcus epidermidis, Pseudomonas aeruginosa, Ceplukan root extract

PENGARUH EKSTRAK BIJI KABAU (Archidendron buballinum (Jack.) I.C.Nielsen) TERHADAP PENURUNAN KADAR GULA DARAH MENCIT PUTIH JANTAN DIABETES YANG DIINDUKSI ALOKSAN Lilik Koernia Wahidah; Nurma Suri; Ratih Anggun Komalasari
JFL : Jurnal Farmasi Lampung Vol. 7 No. 1 (2018): JFL: Jurnal Farmasi Lampung
Publisher : Fakultas MIPA Universitas Tulang Bawang Lampung

Biji kabau (Archidendron buballinum (Jack.) I.C.Nielsen) secara empiris dimanfaatkan masyarakat dibeberapa daerah sebagai obat tradisional antidiabetes dan diuretik herbal. Penelitian ini bertujuan untuk melihat pengaruh ekstrak biji kabau terhadap penurunan kadar gula darah mencit putih jantan yang diinduksi aloksan. Biji kabau diekstraksi dengan cara maserasi menggunakan pelarut etanol 70%. Uji antidiabetes dilakukan terhadap mencit jantan yang diinduksi aloksan secara intravena dengan dosis 168 mg/kgBB selama 15 hari. Sebanyak 25 ekor mencit dikelompokkan menjadi 5 kelompok, kelompok I, II dan III diberi ekstrak dengan dosis 95, 190, dan 380 mg/kgBB, kelompok IV sebagai kontrol negatif diberi aquadest dan kelompok V sebagai kontrol positif diberi metformin dosis 65 mg/kgBB, kelima kelompok diberi perlakuan secara oral sebanyak 3 kali sehari selama 7 hari. Penurunan kadar gula darah diukur dan diamati pada hari ke 1 dan 15 dan hari ke 22 kemudian dianalisis dengan metode ANOVA. Hasil karakteristik simplisia terhadap kadar air 0,23%, kadar abu 2% dan kadar abu tidak larut asam 2%. Uji kualitatif fitokimia ekstrak menunjukkan adanya senyawa flavonoid, alkaloid dan saponin. Hasil analisis menunjukkan kelompok I,II dan III berbeda nyata terhadap kontrol negatif, dan berefek sama terhadap kontrol positif dalam menurunkan kadar gula darah mencit putih jantan. Dari ketiga dosis tersebut dosis 1 (95mg/kgBB) menunjukkan penurunan yang paling baik, namun dosis I,II dan III tidak berbeda nyata secara statistik terhadap metformin. Kata kunci : Kabau, Archidendron buballinum, Diabetes

Optimasi Zeolit Alam Lampung (ZAL) Sebagai Penstabil Sediaan Antibakteri Esktrak Buah Mengkudu (Morinda citrifolia L.) Laila Susanti; Lilik Koernia Wahidah; Pratika Viogenta
JFL : Jurnal Farmasi Lampung Vol. 7 No. 2 (2018): JFL: Jurnal Farmasi Lampung
Publisher : Fakultas MIPA Universitas Tulang Bawang Lampung

Noni fruit extract has been widely known as an antibacterial, but plant extracts are easily degraded by light, pH and temperature, thus reducing the antibacterial activity, zeolite is added to maintain the stability of the noni extract. This study uses an experimental method that is by comparing the inhibition zones that occur between noni fruit extract and noni + ZAL fruit extract and to test the stability of the preparation, the sample is heated at 40oC and then tested for antibacterial activity again. The statistical test results show the value of Asymp. Sig (0.003)

FRAKSI AIR DAUN UBI JALAR (Ipomea batatas (L.) Lam) SEBAGAI HEPATOPROTEKTOR TERHADAP TIKUS PUTIH JANTAN YANG DIINDUKSI PARACETAMOL Lilik Koernia Wahidah; Ramadhan Triyandi; Rima Indriani
JFL : Jurnal Farmasi Lampung Vol. 8 No. 1 (2019): JFL: Jurnal Farmasi Lampung
Publisher : Fakultas MIPA Universitas Tulang Bawang Lampung

Sweet potato leaves (Ipomea batatas (L) Lam ) are empirically used by people in some regions as traditional medicines to treat dengue fever and as anti-cancer because of their high antioxidant content. This study aims to see the effect of sweet potato leaf water fraction as a hepatoprotector on male white rats induced by paracetamol. Sweet potato leaves were extracted by maceration using 70% ethanol for 8 days then fractionation was carried out. The hepatoprotector test was carried out on 25 rats grouped in 5 groups treated orally for 7 days, namely negative controls given aquades, positive controls were given hepamax dose 59.06 mg / kgBB, groups I, II and III were given a fraction of sweet potato leaf water with a dose of 4.77 mg / kgBB, 9.54 mg / kgBB, and 19.08 mg / kgBB then male white rats induced by paracetamol orally at a dose of 1350mg / kgBB for 1 day. The increase in SGPT and SGOT levels was measured on day 9 using spectrophotometry then analyzed by ANOVA method. The results of SGPT analysis showed that groups I, II and III were significantly different from the negative controls (sig 0,000), and had the same effect on positive controls (sig 0.144) in suppressing SGPT level increases while in the analysis results the SGOT group III levels were significantly different from controls negative (sig 0,000) and significantly different from group I, II (sig 0.30 and 0.24), and have the same effect as positive controls (sig 0.392). The third dose (19.08 mg / kgBB) showed the best suppression increased and was not significantly different from statistically positive controls. Based on the research it was concluded that the fraction of sweet potato leaf water could be used as a hepatoprotector for male white rats induced by paracetamol. Keywords: Hepatoprotector, Paracetamol, Sweet Potato Leaves.

THE RELATION BETWEEN KNOWLEDGE AND ATTITUDE TOWARD BEHAVIOR OF ANTIBIOTIC USAGE ON SOCIETY IN TALANG JAWA HEALTH CENTER OF SOUTH LAMPUNG AUGUST PERIOD 2019 Lilik Koernia Wahidah
JFL : Jurnal Farmasi Lampung Vol. 8 No. 2 (2019): JFL: Jurnal Farmasi Lampung
Publisher : Fakultas MIPA Universitas Tulang Bawang Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v8i2.149

In developing countries, many antibiotics are used without a doctor's prescription, causing someone to use antibiotics incorrectly. Lack of knowledge about antibiotics is a major factor that triggers an increase in the rate of bacterial resistance to antibiotics. Knowledge and attitude become one of the social cognitive factors that influence antibiotic use behavior.This study aims to determine the relationship of knowladge and attitudes toward of antibiotic usage behavior in community of Talang jawa public health centre. The research is an observasional analytic research using cross sectional study design. sampling using non-probability sampling methode with type purposive sampling and instruments in the form of questionnaires. The data analysis was based univariate and bivariate analysis eqipped with chi square. The study was conducted on 100 community respondents in the Talang Jawa Health Center. The results showed respondents with good knowledge (25%), enough (27%) and less (48%). Respondents with positive attitudes (64%) and negative attitudes (35%). Respondents with positive behavior (43%) and negative behavior (57%). Chi square test result showed that there was a significant relationship between knowladge and antibiotic use behavior (p= 0,000) and there was a significant relationship between attitude and antibiotic use behavior (p= 0,000). This study has a meaningful relationship between and attitudes with antibiotic use behavior in Talang Jawa Health Center. Keywords: Antibiotics,Knowledge, Attitudes, Behavior

EVALUASI RASIONALITAS PENGGUNAAN OBAT DIABETES MELITUS TIPE II PADA PASIEN RAWAT JALAN DI PUSKESMAS PASIR SAKTI TAHUN 2019 Dwi Aulia Ramdini; Lilik Koernia Wahidah; Dwi Atika
JFL : Jurnal Farmasi Lampung Vol. 9 No. 1 (2020): JFL: Jurnal Farmasi Lampung
Publisher : Fakultas MIPA Universitas Tulang Bawang Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v9i1.334

Abstract Diabetes mellitus is a metabolic disease characterized by hyperglycemia, due to abnormal insulin secretion, insulin action or both. Hyperglycemia is a condition in which blood glucose levels increase or exceed normal limits. This study aims to evaluate the treatment of type II diabetes mellitus in outpatients in Puskesmas Pasir Sakti. This research is a nonexperimental research with a descriptive design taken retrospectively. The sample in this study were all outpatients with a diagnosis of type II diabetes mellitus at Puskesmas Pasir Sakti 2019. The sampling technique used was Total sampling. The sample of this study is the medical record data of patients with type II diabetes mellitus in 2019 adjusted for inclusion criteria. Characteristics based on gender of patients with type II diabetes melitus there are 23 male patients that is 29% and 57 female patients that is 71 %. Characteristics based on the age of most patients in the Elderly (46-65 years) as many as 65 patients (81%). cases of type II diabetes mellitus patients without complications were 39 patients (49%) cases of type II diabetes mellitus patients with complications of 41 patients (51%). The results of the rationality of antidiabetic use in outpatients at the Puskesmas Pasir Sakti in 2019 According to PERKENI 2015 obtained the use of drugs based on the exact parameters indicated as much as 97.5%, the right drugs as much as 98.75%, the right dosage as much as 100%, the right way of administration as much as 100%, the exact time interval of 100%, and medication adherence of 100%. Treatment of type II diabetes melitus who received rational therapy was 96,25% while irational therapy is 3,75%. Keywords: Diabetes Mellitus, Evaluation, Medicine, Rationality.

EVALUASI PENGGUNAAN ANTIBIOTIK PNEUMONIA DENGAN METODE ATC/DDD PADA PASIEN PEDIATRI DI INSTALASI RAWAT INAP RSUD. DR. A. DADI TJOKRODIPO BANDAR LAMPUNG TAHUN 2019 Lilik Koernia Wahidah; Novita Tri Wahyuni; Deska Maharani Putri
JFL : Jurnal Farmasi Lampung Vol. 9 No. 2 (2020): JFL: Jurnal Farmasi Lampung
Publisher : Fakultas MIPA Universitas Tulang Bawang Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v9i2.338

ABSTRACT Pneumonia is an inflammation of the lungs that causes pain during breathing and limited oxygen intake. Antibiotics are the main therapy for pneumonia, appropriate and rational antibiotic therapy will determine the success of treatment to avoid bacterial resistance. The purpose of this study was to evaluate the use of pneumonia antibiotics in pediatric patients with the ATC / DDD method in pediatric patients in the Hospital Dr. Hospital. A. Dadi Tjokrodipo Bandar Lampung in 2019. This research is descriptive in nature with retrospective data collection. The sampling technique used was purposive sampling with a sample size of 70 patients with pediatric pneumonia. The data obtained were analyzed by using ATC / DDD and DU 90% methods. The results showed that from 70 samples studied, it was found that the patient characteristics were based on gender, namely 61.42% of them were male and based on age, namely 65.71% were infant patients aged 1 month - 2 years. The total use of antibiotics was 65.92 DDD / 100 days of hospitalization and antibiotics that entered the 90% DU segment, namely ampicillin (27.53 DDD / 100 days of hospitalization), gentamicin (8.39 DDD / 100 days of hospitalization), azithromycin (7 , 13 DDD / 100 days of care), amoxicillin (6.88 DDD / 100 days of hospitalization) and ampicillin sulbactam (6.6 DDD / 100 days of hospitalization). Then evaluated the use of antibiotics and the results were 100% correct, 100% correct indication, 57.4% correct dose and 100% correct time interval of administration. The use of antibiotic pneumonia in Dr. A. Dadi Tjokrodipo still needs to be improved again, especially regarding the administration of antibiotic doses. Keywords: Antibiotics, ATC, DDD, Pediatrics, Pneumonia.

EVALUASI PENGGUNAAN OBAT ANTIHIPERTENSI PADA PASIEN GERIATRI RAWAT JALAN DI RSUD DR. A. DADI TJOKRODIPO Lilik Koernia Wahidah; Novita Tri Wahyuni; Hijrah Hijrah; Miftahul Choiriah
JFL : Jurnal Farmasi Lampung Vol. 10 No. 1 (2021): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v10i1.493

Hypertension is a condition in which systolic blood pressure â‰¥ 140 mmHg or diastolic blood pressure â‰¥ 90 mmHg. Hypertension is often found in geriatrics that can affect the onslence of heart disease and blood vessels. Increased cases of hypertension, the rational use of drugs by hypertensive patients is one of the important elements in achieving health quality. The purpose of this study is to find out the harsh use of antihypertensive drugs in outpatient geriatric patients at Dr. A. Dadi Tjokrodipo Hospital bandar Lampung. This type of research is non experimental with a descriptive design using retrospective data with purposive sampling methods. The results of the study were based on the pattern of use of antihypertensive with the ATC/DDD method in hypertension patients in Dr. A. Dadi Tjokrodipo Bandar Lampung city is 5331,03 DDD/1000 KPRJ, there are nine types of antihypertensive used, namely amlodipine, lisinopril, candesartan, irbesartan, furosemide, spironolactone, ramipril, bisoprolol and captopril. Antihypertensive in the drug uses segment 90%, namely amlodipine 44.37%, lisinopril 16.88%, candesartan 15.46% and irbesartan 13.65%. The study was based on 100% patient accuracy criteria, 100% indication accuracy, 89.3% drug accuracy and 92% dose accuracy. The conclusion of this study, the pattern of use of antihypertensive widely used is amlodipine amounting to 2365.52 DDD/1000 KPRJ, antihypertensive that enters the drug uses segment 90% namely amlodipine, lisinopril, candesartan and irbesartan.Keywords: Antihypertensive, Geriatrics, Outpatient, Drug Use

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