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All Journal Biota Pharmascience JFL : Jurnal Farmasi Lampung JPSCR : Journal of Pharmaceutical Science and Clinical Research Jurnal Inovasi Pembangunan
Susanti, Laila
FMIPA, Universitas Tulang Bawang, Bandar Lampung
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Formulation Of Ointment From Extract Combination Of Lemongrass (Cymbopogon nardus L. Rendle), Green Betel Leaf (Piper betle L.) And Natural Zeolite As An Antibacterial Agent Laila Susanti; Subur Widodo; Mashuri Yusuf; Retno Fardila Sari
Biota Vol 6 No 2 (2020): Jurnal Biota 2020
Publisher : Faculty of Science and Technology Universitas Islam Negeri Raden Fatah Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19109/10.19109/Biota.v6i2.6363

Abstract

Lemongrass (Cymbopogon nardus L. Rendle) and green betel (Piper betle L.) plants are native to Indonesia. Empirically betel leaf can be used as a wound healer, lemongrass leaves are widely used as medicine for insect bites. On the basis of information obtained from various literatures, in this research has been done formulation of ointment from extract combination of lemongrass, green betel leaf and natural zeolite as antibacterial of Staphylococcus aureus. The use of zeolites based on features has a three-dimensional framework structure that is interconnected so that it has a large surface. Based on these reasons, it is believed that zeolites can increase the activity of active substances in ointments. The formulation of ointment extracts of lemongrass leaves-green betel leaves and zeolites with various dosages are KZ (zeolite control), KE (20% -5%), F1 (10% -6% + zeolite), F2 (20% - 5% + zeolite), F3 (30% -4% + zeolite), F4 (20% -0% + zeolite), F5 (0% -5% + zeolite) with a fixed amount of zeolite (2 gr). Evaluation of ointment preparations including organoleptic test, pH, homogeneity, spreading test and adhesion test showed results that met the requirements. The sample was tested for antibacterial activity with positive control (gentamicin 0.1%) showed that all formulas can provide an inhibition zone against staphylococcus aureus, except KZ. Test results were analyzed using One Way Annova with sig (0,000) <p value (0,050) followed by Tukey's further tests. From this explanation it can be concluded that the formulation of ointment from extract combination of lemongrass leaves, green betel leaves and zeolites has antibacterial agent.
Formulasi Salep Ekstrak Buah Mengkudu (Morinda citrifolia L.) Kombinasi Zeolit Alam Lampung (Zal) Sebagai Penstabil Sediaan Antibakteri Staphylococcus aureus Laila Susanti; Lilik Koernia Wahidah; Pratika Viogenta
Jurnal Pharmascience Vol 7, No 1 (2020): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v7i1.8086

Abstract

ABSTRAK Sediaan salep esktrak buah mengkudu telah terbukti sebagai antibakteri, namun esktrak tanaman pada umumnya sangat mudah terdegradasi oleh pH, cahaya dan suhu, oleh karena itu pemanfaatan Zeolit Alam Lampung (ZAL) dengan keistimewaan struktur morfologinya diharapkan mampu mempertahankan kestabilan sediaan salep hingga suhu tinggi. Penelitian ini bertujuan untuk mengetahui potensi ZAL sebagai penstabil sediaan salep dengan menghitung perubahan prosentase zona hambat bakteri pada sediaan salep sebelum dan sesudah dilakukan penyimpanan pada suhu 40oC. Penelitian ini meliputi tiga tahap utama yakni pertama formulasi salep ekstrak buah mengkudu kombinasi Zeolit Alam Lampung (ZAL) dengan variasi konsentrasi ekstrak 10%+ZAL, 15%+ZAL, 30%+ZAL, KZ (Kontrol Zeolit tanpa esktrak) dan KE (Kontrol Ekstrak tanpa zeolit) yang kemudian dilakukan evaluasi sediaan salep. Tahap kedua seluruh sampel dilakukan uji aktivitas antibakteri terhadap bakteri Staphylococcus aureus pada sediaan salep, dan tahap ketiga seluruh sampel disimpan pada suhu 40oC selama 24 jam, kemudian diuji aktivitas antibakteri kembali terhadap bakteri Staphylococcus aureus. Hasil penelitian menunjukkan bahwa seluruh sampel sebelum dilakukan penyimpanan pada suhu 40oC menunjukkan respon zona hambat bakteri yang kuat kecuali KZ. Setelah dilakukan penyimpanan pada suhu 40oC, terjadi penurunan zona hambat pada KE dan Ekstrak 10%+ZAL sebesar 100% dan 36,81%. Hal yang menarik terjadi pada Esktrak 15%+ZAL dan 30%+ZAL, yakni terjadi kenaikan zona hambat sebesar 35,20 % dan 31,32%. Hasil uji statistik menunjukkan nilai Asymp. Sig (0,016) <  nilai p (0,01) maka H0 ditolak sehingga dilakukan uji lanjut Tukey yang menunjukkan terjadi perbedaan yang signifikan antar kelompok uji. Dari penjelasan tersebut maka dapat disimpulkan bahwa ZAL mampu meningkatkan kinerja sediaan salep ekstrak buah mengkudu terutama pada konsentrasi 15% dan 30% dalam menghambat bakteri Staphylococcus aureus sehingga sediaan salep esktrak buah mengkudu kombinasi ZAL dapat digunakan sebagai alternatif obat pengganti obat sintetik kimiawi.  Kata kunci : Zeolit, Salep, M.citrifolia L, Staphylococcus aureus ABSTRACT             Noni extract ointment has been proven to be antibacterial, but plant extracts are generally very easily degraded by pH, light and temperature, therefore the use of Lampung Natural Zeolite (ZAL) with its special morphological structure is expected to be able to maintain the stability of ointment preparations to high temperatures. This study aims to determine the potential of ZAL as a stabilizer for ointment preparations by calculating the change in the percentage of bacterial inhibition zones in ointment preparations before and after storage at 40oC. This study includes three main stages, namely the first formulation of noni extracts from Lampung Natural Zeolite extract (ZAL) with variations in extract concentration of 10% + ZAL, 15% + ZAL, 30% + ZAL, KZ (Zeolite control without extract) and KE (Control Extract without zeolite) which then evaluated the ointment preparation. The second stage of all samples was tested for antibacterial activity against Staphylococcus aureus bacteria in ointment preparations, and the third stage all samples were stored at 40oC for 24 hours, then tested for antibacterial activity against Staphylococcus aureus. The results showed that all samples before storage at 40oC showed a strong inhibitory zone response except KZ. After storage at 40oC, there was a decrease in inhibition zones at KE and Extract 10% + ZAL by 100% and 36.81%. An interesting thing happened at the Extract 15% + ZAL and 30% + ZAL, namely an increase in inhibition zones of 35.20% and 31.32%. Statistical test results indicate the Asymp value. Sig (0.016) >p value (0.01) then H0 is accepted, so Tukey's further tests show that there are significant differences between the test groups. From this explanation it can be concluded that ZAL can improve the performance of noni fruit extract ointment especially at concentrations of 15% and 30% in inhibiting Staphylococcus aureus bacteria so that the ZAL noni extract extract can be used as an alternative drug for chemical synthetic drugs. Keywords : Zeolite, Ointment, M.citrifolia L, Staphylococcus aureus
Uji Formulasi Sediaan Salep Ekstrak Batang Brotowali (Tinospora Crispa L. Miers ) Kombinasi Zeolit Terhadap Bakteri Staphylococcus Aureus dan Pseudomonas Aeruginosa Laila Susanti; Subur Widodo; Syaiful Bahri; Wenny Indriasari
Inovasi Pembangunan : Jurnal Kelitbangan Vol 4 No 03 (2016): November 2016
Publisher : Balitbangda Provinsi Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (382.591 KB)

Abstract

Treatment of infected wounds on the skin generally use synthetic chemicals, which when used in the long term lead to negative side effects. Development of herbal medicines have been done as an alternative to synthetic chemicals because of cheap and has no side effects and low toxicity. From this background, the test formulation extract ointment preparation brotowali (Tinospora crispa L. Miers) a combination of zeolite against Staphylococcus aureus and Pseudomonas aeruginosa in vitro. This study aims to get the best formulation of the extract ointment preparation brotowali (Tinospora crispa L. Miers) which has an antibacterial effect against Staphylococcus aureus and Pseudomonas aeruginosa. In this study, the method used discs to observe the growth of bacteria by doing two to three treatments. P1 was the treatment group were given a salve on the market, namely the ointment Gentamicin as a positive control, P2 is the treatment group were given an ointment containing extract brotowali combination of zeolite with base oils, P3 is the treatment group were given ointment without extract brotowali oily base as a negative control. From the research results generated extract ointment brotowali with base oils produced are bactericidal and active substance formulations extract brotowali combination of zeolite that is at 9%v/v.
UJI KADAR NITRIT PADA DAGING BURGER DI KOTA BANDAR LAMPUNG MENGGUNAKAN SPEKTROFOTOMETRI UV-VIS Laila Susanti; Merinda Setyowati; Subur Widodo; Anita Setiawati
JFL : Jurnal Farmasi Lampung Vol. 7 No. 1 (2018): JFL: Jurnal Farmasi Lampung
Publisher : Fakultas MIPA Universitas Tulang Bawang Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v7i1.38

Abstract

Daging merupakan salah satu sumber makanan yang berasal dari hewani dan memiliki cita rasa yang khas serta kandungan gizi yang tinggi. Dari berbagai cara pengolahan daging, daging burger merupakan salah satu produk olahan yang banyak dikonsumsi masyarakat. Sebagai bahan pengawet pada daging burger digunakan nitrit, untuk memperpanjang waktu simpan. Tujuan dari penelitian ini adalah untuk mengetahui kadar nitrit pada daging burger dengan menggunakan Spektrofotometri Uv-Vis. Sebagai pelarut digunakan asam sulfanilat bereaksi dengan asam nitrit membentuk garam diazonium kemudian ditambah pelarut naftilamin membentuk senyawa azo yang berwarna ungu, lalu diukur absorbansinya pada panjang gelombang 531 nm. Hasil penelitian menunjukan kadar rata-rata nitrit pada masing- masing sampel A ,B, C, D, E, F secara berurutan adalah 123,95 mg/kg, 30,14 mg/kg, 195,25 mg/kg, 105,74 mg/kg, 20,85 mg/kg dan 16,14 mg/kg. Dari ke enam sampel, ada 4 sampel yang memiliki kandungan nitrit melebihi ambang batas maksimum penggunaan bahan pengawet pada makanan menurut Peraturan Kepala BPOM RI Nomor 36 Tahun 2013 yaitu sebesar 30 mg/kg untuk produk daging olahan. Hanya sampel C yang memiliki kadar nitrit melebihi batas maksimum persyaratan berdasarkan Permenkes Nomor 1168/Menkes/Per/X/1999, yaitu 125 mg/kg. Kata Kunci : Daging burger, Nitrit, Spektrofotometri UV-Vis
Optimasi Zeolit Alam Lampung (ZAL) Sebagai Penstabil Sediaan Antibakteri Esktrak Buah Mengkudu (Morinda citrifolia L.) Laila Susanti; Lilik Koernia Wahidah; Pratika Viogenta
JFL : Jurnal Farmasi Lampung Vol. 7 No. 2 (2018): JFL: Jurnal Farmasi Lampung
Publisher : Fakultas MIPA Universitas Tulang Bawang Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (215.262 KB) | DOI: 10.37090/jfl.v7i2.54

Abstract

Noni fruit extract has been widely known as an antibacterial, but plant extracts are easily degraded by light, pH and temperature, thus reducing the antibacterial activity, zeolite is added to maintain the stability of the noni extract. This study uses an experimental method that is by comparing the inhibition zones that occur between noni fruit extract and noni + ZAL fruit extract and to test the stability of the preparation, the sample is heated at 40oC and then tested for antibacterial activity again. The statistical test results show the value of Asymp. Sig (0.003)
ANALISIS BIOAUTOGRAFI DAN KARAKTERISASI DENGAN FTIR PADA FRAKSI DAUN LABU SIAM (Sechium edule (jacq).SW) TERHADAP Porphyromonas gingivalis DAN Streptococcus mutans Laila Susanti; Isbiyantoro Isbiyantoro; Septiana Simanjuntak
JFL : Jurnal Farmasi Lampung Vol. 8 No. 1 (2019): JFL: Jurnal Farmasi Lampung
Publisher : Fakultas MIPA Universitas Tulang Bawang Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (503.009 KB) | DOI: 10.37090/jfl.v8i1.87

Abstract

Siamese pumpkin leaves are one of the plants that have antibacterial properties. Compounds that act as antibacterial are flavonoite, tannin, triterpenes, alkaloids, and saponins. The aim of this study was to prove the antibacterial activity of ethanol hexane and chloroform fraction of pumpkin siam leaves and characterize the functional groups of active compounds from pumpkin siam leaves (Sechium edule (jacq). SW) with FTIR spectrophotometers. The extraction process of Siamese Pumpkin leaves was carried out by maceration method using 70% ethanol. The extract was continued with the fractionation process with ethanol, n-hexane and chloroform solvents. Antibacterial activity testing using the well method with a concentration of 100%, positive control chlorhexidi and negative control aquadst. The compound content test used the Thin Layer Chromatography (TLC) method with the stationary phase using silica plate G60 F254 and comparison of the mobile phase of chloroform: methanol: water (2: 5: 3) (v / v). Bioautography test using the contact method, namely the elution TLC plate, was placed on the NA medium containing a bacterial suspension for 3 hours. Antibacterial test results The largest ethanol fraction of pumpkin leaves was at a concentration of 100% with a diameter of inhibition zone of 11.49 mm on P. gingivalis while 16.04 mm in S. mutans. The results of TLC showed the presence of flavonoids with a price of Rf 0.47 and tannin with a price of Rf 0.84. Bioautography results showed a inhibition zone with a price of Rf 0.49 in the bacteria P. gingivalis and S. mutans which are flavonoid compounds. Characterization by FTIR spectrophotometer O-H phenol, C = C aromatic, C-O-C ether, aromatic C-H functional group Keywords: (Sechium edule (jacq) .SW). Porphyromonas Gingivalis, Streptococcus mutans, TLC, Bioautography and FTIR
Activity Test of Durian Peels Essential Oil (Durio zibethinus) as an Antipediculosis Against Pediculus humanus capitis Linn. (Anoplura: Pediculidae) Yuli Wahyu Tri Mulyani; Siti Nurjanah; Samsuar Samsuar; Laila Susanti
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 6, No 3 (2021)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v6i3.49900

Abstract

Pediculosis is a disease caused by infestation of head lice (Pediculus humanus capitis) which is a blood-sucking obligate ectoparasite. The essential oil of durian fruit peel has active compounds that have the potential as vegetable pediculosides that can kill head lice. This study aimed to find the best concentration of essential oil from durian fruit peels that can kill head lice. The research design used with an essential oil concentration of 100%, 75%, 50%, 25%, distilled water as negative control and permethrin 1% as positive control, three repetitions and each concentration consisting of 10 flea tails. The parameters observed were the condition of lice morphologically based on the activity of limb movement, antenna movement and digestion, then the calculation of mortality was observed based on the time of the test. The results showed that the concentration of durian peel essential oil as an antipediculosis had a significant effect on the time of death of head lice, limb movement and digestion. The test result showed that the concentration is 100%, has a death time of 12 minutes 32 seconds, 75% concentration was 16 minutes 28 seconds, 50% concentration was 21 minutes 11 seconds, 25% concentration was 32 minutes 23 seconds, negative control was 61 minutes 15 seconds. The fastest time of death in positive control for chemical pediculosides was 10 minutes 15 seconds. The conclusion in this study was that essential oils the dominan one is 1,5-naphthyridin-2-amine were proven to kill head lice and the best concentration was close to positive control, namely at a concentration of 100%.
Co-Authors Anita Setiawati Isbiyantoro Isbiyantoro Lilik Koernia Wahidah Mashuri Yusuf Merinda Setyowati Retno Fardila Sari Samsuar User Septiana Simanjuntak Siti Nurjanah Subur Widodo Syaiful Bahri Viogenta, Pratika Wenny Indriasari Widodo, Subur Yuli Wahyu Tri Mulyani